A causal role for endothelin-1 in the vascular adaptation to skeletal muscle deconditioning in spinal cord injury

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 27, Issue 2, 2007, Pages 325-331

  Thijssen, Dick H J ^a   Ellenkamp, Reinier ^a   Kooijman, Miriam ^a   Pickkers, Peter ^a   Rongen, Gerard A ^a   Hopman, Maria T E ^a   Smits, Paul ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cardiovascular disease; Endothelin receptor; Endothelium; Exercise; Paraplegia

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST;

ADAPTATION; ADULT; ARTICLE; BLOOD VESSEL FUNCTION; BLOOD VESSEL TONE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; ELECTROSTIMULATION; EXERCISE; FEMALE; FEMORAL ANGIOGRAPHY; HUMAN; IMMOBILIZATION; INFUSION; LEG BLOOD FLOW; MALE; MEASUREMENT; MUSCLE BLOOD FLOW; PLETHYSMOGRAPHY; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; REPEAT PROCEDURE; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SPINAL CORD INJURY; STATISTICAL SIGNIFICANCE; THIGH; TRAINING; VASODILATATION;

ADULT; ANTIHYPERTENSIVE AGENTS; CASE-CONTROL STUDIES; ELECTRIC STIMULATION THERAPY; ENDOTHELIN-1; EXERCISE; FEMALE; FEMORAL ARTERY; HUMANS; MALE; MIDDLE AGED; MUSCLE, SKELETAL; MUSCULAR ATROPHY; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PIPERIDINES; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; SPINAL CORD INJURIES; VASODILATION;

EID: 33846463436     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000253502.83167.31     Document Type: Article

References (36)

1. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411-415.
2. Verhaar MC, Strachan FE, Newby DE, Cruden NL, Koomans HA, Rabelink TJ, Webb DJ. Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade. Circulation. 1998;97:752-756.
3. Haynes WG, Webb DJ. Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet. 1994;344:852-854.
4. Arai H, Hori S, Aramori I, Ohkubo H, Nakanishi S. Cloning and expression of a cDNA encoding an endothelin receptor. Nature. 1990;348:730-732.
5. Haynes WG, Strachan FE, Webb DJ. Endothelin ETA and ETB receptors cause vasoconstriction of human resistance and capacitance vessels in vivo. Circulation. 1995;92:357-363.
6. Tsukahara H, Ende H, Magazine HI, Bahou WF, Goligorsky MS. Molecular and functional characterization of the non-isopeptide-selective ETB receptor in endothelial cells. Receptor coupling to nitric oxide synthase. J Biol Chem. 1994;269:21778-21785.
7. de Nucci G, Thomas R, D'Orleans-Juste P, Antunes E, Walder C, Warner TD, Vane JR. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc Natl Acad Sci U S A. 1988;85:9797-9800.
8. Stewart DJ, Levy RD, Cernacek P, Langleben D. Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease? Ann Intern Med. 1991;114:464-469.
9. Haynes WG, Hand MF, Johnstone HA, Padfield PL, Webb DJ. Direct and sympathetically mediated venoconstriction in essential hypertension. Enhanced responses to endothelin-1. J Clin Invest. 1994;94:1359-1364.
10. Hurlimann D, Enseleit F, Noll G, Luscher TF, Ruschitzka F. Endothelin antagonists and heart failure. Curr Hypertens Rep. 2002;4:85-92.
11. McMurray JJ, Ray SG, Abdullah I, Dargie HJ, Morton JJ. Plasma endothelin in chronic heart failure. Circulation. 1992;85:1374-1379.
12. Barton M, Carmona R, Ortmann J, Krieger JE, Traupe T. Obesity-associated activation of angiotensin and endothelin in the cardiovascular system. Int J Biochem Cell Biol. 2003;35:826-837.
13. Bleeker MW, De Groot PC, Poelkens F, Rongen GA, Smits P, Hopman MT. Vascular adaptation to 4 wk of deconditioning by unilateral lower limb suspension. Am J Physiol Heart Circ Physiol. 2005;288:H1747-H1755.
14. Hirayanagi K, Iwase S, Kamiya A, Watanabe Y, Shiozawa T, Yamaguchi N, Yajima K, Mano T Alternations of static cerebral and systemic circulation in normal humans during 14-day head-down bed rest. Med Sci Monit. 2005;11:CR570-CR575.
15. Hopman MT, Groothuis JT, Flendrie M, Gerrits KH, Houtman S. Increased vascular resistance in paralyzed legs after spinal cord injury is reversible by training. J Appl Physiol. 2002;93:1966-1972.
16. Bleeker MW, Kooijman M, Rongen GA, Hopman MT, Smits P. Preserved contribution of nitric oxide to baseline vascular tone in deconditioned human skeletal muscle. J Physiol. 2005;565:685-694.
17. Kooijman M, Rongen GA, Smits P, Hopman MT. Preserved alpha-adrenergic tone in the leg vascular bed of spinal cord-injured individuals. Circulation. 2003;108:2361-2367.
18. Lakka TA, Venalainen JM, Rauramaa R, Salonen R, Tuomilehto J, Salonen JT. Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction. N Engl J Med. 1994;330:1549-1554.
19. Maynard FM, Jr., Bracken MB, Creasey G, Ditunno JF, Jr., Donovan WH, Ducker TB, Garber SL, Marino RJ, Stover SL, Tator CH, Waters RL, Wilberger JE, Young W. International Standards for Neurological and Functional Classification of Spinal Cord Injury. American Spinal Injury Association. Spinal Cord. 1997;35:266-274.
20. Groothuis JT, van Vliet L, Kooijman M, Hopman MT. Venous cuff pressures from 30 mmHg to diastolic pressure are recommended to measure arterial inflow by plethysmography. J Appl Physiol. 2003;95:342-347.
21. Thijssen DH, Bleeker MW, Smits P, Hopman MT. Reproducibility of blood flow and post-occlusive reactive hyperaemia as measured by venous occlusion plethysmography. Clin Sci (Lond). 2005;108:151-157.
22. Goddard J, Webb DJ Endothelin antagonists and hypertension: a question of dose? Hypertension. 2002;40:e1-e2; author reply e1-e2.
23. Jones PRP J. Anthropometric determination of leg fat and muscle plus bone volumes in young male and female adults. J Physiol. 1969;63P-66P.
24. Helmy A, Newby DE, Jalan R, Hayes PC, Webb DJ. Enhanced vasodilatation to endothelin antagonism in patients with compensated cirrhosis and the role of nitric oxide. Gut. 2003;52:410-415.
25. Thijssen DH, Ellenkamp R, Smits P, Hopman MT. Rapid vascular adaptations to training and detraining in persons with spinal cord injury. Arch Phys Med Rehabil. 2006;87:474-481.
26. Thijssen DH, Heesterbeek P, van Kuppevelt DJ, Duysens J, Hopman MT. Local vascular adaptations after hybrid training in spinal cord-injured subjects. Med Sci Sports Exerc. 2005;37:1112-1118.
27. Petrie JR, Ueda S, Morris AD, Murray LS, Elliott HL, Connell JM. How reproducible is bilateral forearm plethysmography? Br J Clin Pharmacol. 1998;45:131-139.
28. Wimalasundera RC, Mc GTSA, Regan L, Hughes AD. Action of the endothelin receptor (ETA) antagonist BQ-123 on forearm blood flow in young normotensive subjects. Clin Sci (Lond). 2002;102:661-666.
29. Strachan FE, Spratt JC, Wilkinson IB, Johnston NR, Gray GA, Webb DJ. Systemic blockade of the endothelin-B receptor increases peripheral vascular resistance in healthy men. Hypertension. 1999;33:581-585.
30. Newcomer SC, Leuenberger UA, Hogeman CS, Handly BD, Proctor DN. Different vasodilator responses of human arms and legs. J Physiol. 2004;556:1001-1011.
31. Han SP, Trapani AJ, Fok KF, Westfall TC, Knuepfer MM. Effects of endothelin on regional hemodynamics in conscious rats. Eur J Pharmacol. 1989;159:303-305.
32. Jones AW, Rubin LJ, Magliola L. Endothelin-1 sensitivity of porcine coronary arteries is reduced by exercise training and is gender dependent. J Appl Physiol. 1999;87:1172-1177.
33. Latorre E, Moran M, Aragones MD, Saborido A, Fernandez I, Delgado J, Catalan RE, Megias A. Exercise training-induced changes in sensitivity to endothelin-1 and aortic and cerebellum lipid profile in rats. Lipids. 2002;37:43-52.
34. Luscher TF. Endothelin: systemic arterial and pulmonary effects of a new peptide with potent biologic properties. Am Rev Respir Dis. 1992;146:S56-S60.
35. Maggioni M, Bertoli S, Margonato V, Merati G, Veicsteinas A, Testolin G Body composition assessment in spinal cord injury subjects. Acta Diabetol. 2003;40 Suppl 1:S183-S186.
36. Rongen GA, Lambrou G, Smits P. Flow ratios to express results obtained with the human in vivo 'perfused forearm technique'. Br J Clin Pharmacol. 1999;48:258-261.