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Volumn 23, Issue 4, 2007, Pages 781-792

CpG oligodeoxynucleotides up-regulate antibacterial systems and induce protection against bacterial challenge in rainbow trout (Oncorhynchus mykiss)

Author keywords

Adjuvant; Bacterial challenge; Chemoattractant; CpG; Lysozyme; Rainbow trout

Indexed keywords

BACTERIA (MICROORGANISMS); MAMMALIA; ONCORHYNCHUS MYKISS;

EID: 34547597766     PISSN: 10504648     EISSN: 10959947     Source Type: Journal    
DOI: 10.1016/j.fsi.2007.02.006     Document Type: Article
Times cited : (46)

References (46)
  • 1
    • 0034142182 scopus 로고    scopus 로고
    • Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
    • Hartmann G., Weeratna R.D., Ballas Z.K., Payette P., Blackwell S., Suparto I., et al. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo. Immunology 164 (2000) 1617-1624
    • (2000) Immunology , vol.164 , pp. 1617-1624
    • Hartmann, G.1    Weeratna, R.D.2    Ballas, Z.K.3    Payette, P.4    Blackwell, S.5    Suparto, I.6
  • 2
    • 0031867535 scopus 로고    scopus 로고
    • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
    • Sparwasser T., Koch E.-S., Vabulas R.M., Heeg K., Lipford G.B., Ellwart J.W., et al. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 28 (1998) 2045-2054
    • (1998) Eur J Immunol , vol.28 , pp. 2045-2054
    • Sparwasser, T.1    Koch, E.-S.2    Vabulas, R.M.3    Heeg, K.4    Lipford, G.B.5    Ellwart, J.W.6
  • 3
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas Z.K., Rasmussen W.L., and Krieg A.M. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol 157 (1996) 1840-1845
    • (1996) J Immunol , vol.157 , pp. 1840-1845
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 4
    • 0029738445 scopus 로고    scopus 로고
    • Activation of human B cells by phosphorothioate oligodeoxynucleotides
    • Liang H., Nishioka Y., Reich C.F., Pisetsky D.S., and Lipsky P.E. Activation of human B cells by phosphorothioate oligodeoxynucleotides. J Clin Invest 98 (1996) 1119-1129
    • (1996) J Clin Invest , vol.98 , pp. 1119-1129
    • Liang, H.1    Nishioka, Y.2    Reich, C.F.3    Pisetsky, D.S.4    Lipsky, P.E.5
  • 5
    • 0026006734 scopus 로고
    • Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA
    • Messina J.P., Gilkeson G.S., and Pisetsky D.S. Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J Immunol 147 (1991) 1759-1764
    • (1991) J Immunol , vol.147 , pp. 1759-1764
    • Messina, J.P.1    Gilkeson, G.S.2    Pisetsky, D.S.3
  • 6
    • 0034671061 scopus 로고    scopus 로고
    • CpG Oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression
    • Takeshita S., Takeshita F., Haddad D.E., Ishii K.J., and Klinman D.M. CpG Oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression. Cell Immunol 206 (2000) 101-106
    • (2000) Cell Immunol , vol.206 , pp. 101-106
    • Takeshita, S.1    Takeshita, F.2    Haddad, D.E.3    Ishii, K.J.4    Klinman, D.M.5
  • 7
    • 0030589385 scopus 로고    scopus 로고
    • Rapid immune activation by CpG motifs in bacterial DNA: systemic induction of IL-6 transcription through an antioxidant-sensitive pathway
    • Yi A.-K., Klinmann D.M., Martin T.L., Matson S., and Krieg A.M. Rapid immune activation by CpG motifs in bacterial DNA: systemic induction of IL-6 transcription through an antioxidant-sensitive pathway. J Immunol 157 (1996) 5394-5402
    • (1996) J Immunol , vol.157 , pp. 5394-5402
    • Yi, A.-K.1    Klinmann, D.M.2    Martin, T.L.3    Matson, S.4    Krieg, A.M.5
  • 8
    • 0035370099 scopus 로고    scopus 로고
    • Now I know my CpGs
    • Krieg A. Now I know my CpGs. Trends Microbiol 9 (2001) 249-252
    • (2001) Trends Microbiol , vol.9 , pp. 249-252
    • Krieg, A.1
  • 9
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 20 (2002) 709-760
    • (2002) Annu Rev Immunol , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 10
    • 0032168355 scopus 로고    scopus 로고
    • CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
    • Krieg A.M., Love-Homan L., Yi A.-K., and Harty J.T. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J Immunol 161 (1998) 2428-2434
    • (1998) J Immunol , vol.161 , pp. 2428-2434
    • Krieg, A.M.1    Love-Homan, L.2    Yi, A.-K.3    Harty, J.T.4
  • 11
    • 2942549527 scopus 로고    scopus 로고
    • Use of CpG oligodeoxynucleotides as immune adjuvants
    • Klinman D.M., Currie D., Gursel I., and Verthelyi D. Use of CpG oligodeoxynucleotides as immune adjuvants. Immunol Rev 199 (2004) 201-216
    • (2004) Immunol Rev , vol.199 , pp. 201-216
    • Klinman, D.M.1    Currie, D.2    Gursel, I.3    Verthelyi, D.4
  • 12
    • 0033980073 scopus 로고    scopus 로고
    • The role of CpG motifs in innate immunity
    • Krieg A.M. The role of CpG motifs in innate immunity. Curr Opin Immunol 12 (2000) 35-43
    • (2000) Curr Opin Immunol , vol.12 , pp. 35-43
    • Krieg, A.M.1
  • 13
    • 0035865054 scopus 로고    scopus 로고
    • Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs
    • Verthelyi D., Ishii K.J., Gursel M., Takeshita F., and Klinman D.M. Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J Immunol 166 (2001) 2372-2377
    • (2001) J Immunol , vol.166 , pp. 2372-2377
    • Verthelyi, D.1    Ishii, K.J.2    Gursel, M.3    Takeshita, F.4    Klinman, D.M.5
  • 14
    • 4444307268 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides stimulate immune cell proliferation but not specific antibody production in rainbow trout (Oncorhynchus mykiss)
    • Carrington A.C., Collet B., Holland J.W., and Secombes C.J. CpG oligodeoxynucleotides stimulate immune cell proliferation but not specific antibody production in rainbow trout (Oncorhynchus mykiss). Vet Immunol Immunopathol 101 (2004) 211-222
    • (2004) Vet Immunol Immunopathol , vol.101 , pp. 211-222
    • Carrington, A.C.1    Collet, B.2    Holland, J.W.3    Secombes, C.J.4
  • 15
    • 0035126964 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides and plasmid DNA stimulate Atlantic salmon (Salmo salar L.) leucocytes to produce supernatants with antiviral activity
    • Jørgensen J.B., Johansen A., Stenersen B., and Sommer A.-I. CpG oligodeoxynucleotides and plasmid DNA stimulate Atlantic salmon (Salmo salar L.) leucocytes to produce supernatants with antiviral activity. Dev Comp Immunol 25 (2001) 313-321
    • (2001) Dev Comp Immunol , vol.25 , pp. 313-321
    • Jørgensen, J.B.1    Johansen, A.2    Stenersen, B.3    Sommer, A.-I.4
  • 16
    • 0142028886 scopus 로고    scopus 로고
    • CpG DNA induces protective antiviral immune responses in Atlantic salmon (Salmo salar L.)
    • Jørgensen J.B., Johansen L.-H., Steiro K., and Johansen A. CpG DNA induces protective antiviral immune responses in Atlantic salmon (Salmo salar L.). J Virol 77 (2003) 11471-11479
    • (2003) J Virol , vol.77 , pp. 11471-11479
    • Jørgensen, J.B.1    Johansen, L.-H.2    Steiro, K.3    Johansen, A.4
  • 17
    • 27644452544 scopus 로고    scopus 로고
    • Stimulation of type I IFN activity in Atlantic salmon (Salmo salar L.) leukocytes: synergistic effects of cationic proteins and CpG ODN
    • Pedersen G.M., Johansen A., Olsen R.L., and Jørgensen J.B. Stimulation of type I IFN activity in Atlantic salmon (Salmo salar L.) leukocytes: synergistic effects of cationic proteins and CpG ODN. Fish Shellfish Immunol 20 (2006) 503-518
    • (2006) Fish Shellfish Immunol , vol.20 , pp. 503-518
    • Pedersen, G.M.1    Johansen, A.2    Olsen, R.L.3    Jørgensen, J.B.4
  • 18
    • 27644566068 scopus 로고    scopus 로고
    • A newly identified CpG oligodeoxynucleotide motif that stimulates rainbow trout (Oncorhynchus mykiss) immune cells to produce immunomodulatory factors
    • Shen K.-Y., Hogstrand C., and Davies D.H. A newly identified CpG oligodeoxynucleotide motif that stimulates rainbow trout (Oncorhynchus mykiss) immune cells to produce immunomodulatory factors. Dev Comp Immunol 30 (2006) 311-324
    • (2006) Dev Comp Immunol , vol.30 , pp. 311-324
    • Shen, K.-Y.1    Hogstrand, C.2    Davies, D.H.3
  • 19
    • 0037437068 scopus 로고    scopus 로고
    • The in vitro effect of CpG-ODNs on the innate immune response of common carp, Cyprinus carpio L
    • Tassakka ACMAR, and Sakai M. The in vitro effect of CpG-ODNs on the innate immune response of common carp, Cyprinus carpio L. Aquaculture 220 (2003) 27-36
    • (2003) Aquaculture , vol.220 , pp. 27-36
    • Tassakka ACMAR1    Sakai, M.2
  • 20
    • 0037189651 scopus 로고    scopus 로고
    • CpG Oligodeoxynucleotides enhance the non-specific immune responses on carp, Cyprinus carpio
    • Tassakka ACMAR, and Sakai M. CpG Oligodeoxynucleotides enhance the non-specific immune responses on carp, Cyprinus carpio. Aquaculture 209 (2002) 1-10
    • (2002) Aquaculture , vol.209 , pp. 1-10
    • Tassakka ACMAR1    Sakai, M.2
  • 21
    • 0141538058 scopus 로고    scopus 로고
    • CpG motif in synthetic ODN primes respiratory burst of olive flounder Paralichthys olivaceus phagocytes and enhances protection against Edwardsiella tarda
    • Lee C.H., Jeong H.D., Chung J.K., Lee H.H., and Kim K.H. CpG motif in synthetic ODN primes respiratory burst of olive flounder Paralichthys olivaceus phagocytes and enhances protection against Edwardsiella tarda. Dis Aquatic Org 56 (2003) 43-48
    • (2003) Dis Aquatic Org , vol.56 , pp. 43-48
    • Lee, C.H.1    Jeong, H.D.2    Chung, J.K.3    Lee, H.H.4    Kim, K.H.5
  • 22
    • 0037391610 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides activate grass carp (Ctenopharyngodon idellus) macrophages
    • Meng Z., Shao J., and Xiang L. CpG oligodeoxynucleotides activate grass carp (Ctenopharyngodon idellus) macrophages. Dev Comp Immunol 27 (2003) 313-321
    • (2003) Dev Comp Immunol , vol.27 , pp. 313-321
    • Meng, Z.1    Shao, J.2    Xiang, L.3
  • 23
    • 0036140062 scopus 로고    scopus 로고
    • Activation of nonspecific cytotoxic cells (NCC) with synthetic oligodeoxynucleotides and bacterial genomic DNA: binding, specificity and identification of unique immunostimulatory motifs
    • Oumouna M., Jaso-Friedmann L., and Evans D.L. Activation of nonspecific cytotoxic cells (NCC) with synthetic oligodeoxynucleotides and bacterial genomic DNA: binding, specificity and identification of unique immunostimulatory motifs. Dev Comp Immunol 26 (2002) 257-269
    • (2002) Dev Comp Immunol , vol.26 , pp. 257-269
    • Oumouna, M.1    Jaso-Friedmann, L.2    Evans, D.L.3
  • 24
    • 1842855301 scopus 로고    scopus 로고
    • Efficacy of cellular vaccines and genetic adjuvants against bacterial kidney disease in chinook salmon (Oncorhynchus tshawytscha)
    • Rhodes L.D., Rathbone C.K., Corbett S.C., Harrell L.W., and Strom M.S. Efficacy of cellular vaccines and genetic adjuvants against bacterial kidney disease in chinook salmon (Oncorhynchus tshawytscha). Fish Shellfish Immunol 16 (2004) 461-474
    • (2004) Fish Shellfish Immunol , vol.16 , pp. 461-474
    • Rhodes, L.D.1    Rathbone, C.K.2    Corbett, S.C.3    Harrell, L.W.4    Strom, M.S.5
  • 26
    • 0001557857 scopus 로고
    • Isolation of salmonid macrophages and analysis of their killing activity
    • Stolen J.S., Anderson T.C.F., Robertson D.P., and van Muiswinkel W.B. (Eds), SOS Publications, Fair Haven, NJ
    • Secombes C.J. Isolation of salmonid macrophages and analysis of their killing activity. In: Stolen J.S., Anderson T.C.F., Robertson D.P., and van Muiswinkel W.B. (Eds). Techniques in fish immunology, vol. 1 (1990), SOS Publications, Fair Haven, NJ 137-154
    • (1990) Techniques in fish immunology , vol.1 , pp. 137-154
    • Secombes, C.J.1
  • 27
    • 34547598666 scopus 로고    scopus 로고
    • Immune responses elicited by CpG ODN and DNA vaccines in rainbow trout (Oncorhynchus mykiss)
    • University of Aberdeen, Aberdeen 1-266
    • Carrington A.C. Immune responses elicited by CpG ODN and DNA vaccines in rainbow trout (Oncorhynchus mykiss). Ph.D. Thesis, School of biological sciences (2003), University of Aberdeen, Aberdeen 1-266
    • (2003) Ph.D. Thesis, School of biological sciences
    • Carrington, A.C.1
  • 28
    • 0018885287 scopus 로고
    • A 48-well micro-chemotaxis assembly for rapid and accurate measurement of leukocyte migration
    • Falk W., Goodwin R.H., and Leonard E.J.J. A 48-well micro-chemotaxis assembly for rapid and accurate measurement of leukocyte migration. J Immunol Methods 33 (1980) 239-247
    • (1980) J Immunol Methods , vol.33 , pp. 239-247
    • Falk, W.1    Goodwin, R.H.2    Leonard, E.J.J.3
  • 29
    • 0035214052 scopus 로고    scopus 로고
    • Rainbow trout (Oncorhynchus mykiss) recombinant IL-1β and derived peptides induce migration of head-kidney leucocytes in vitro
    • Peddie S., Zou J., Cunningham C., and Secombes C.J. Rainbow trout (Oncorhynchus mykiss) recombinant IL-1β and derived peptides induce migration of head-kidney leucocytes in vitro. Fish Shellfish Immunol 11 (2001) 697-709
    • (2001) Fish Shellfish Immunol , vol.11 , pp. 697-709
    • Peddie, S.1    Zou, J.2    Cunningham, C.3    Secombes, C.J.4
  • 30
    • 33846436746 scopus 로고    scopus 로고
    • Modified Weibull multi-state models for the analysis of animal carcinogenicity data
    • Stallard N., and Whitehead A. Modified Weibull multi-state models for the analysis of animal carcinogenicity data. Environ Ecol Stat 7 (2000) 117-133
    • (2000) Environ Ecol Stat , vol.7 , pp. 117-133
    • Stallard, N.1    Whitehead, A.2
  • 31
    • 0034307339 scopus 로고    scopus 로고
    • The Toll receptor family and microbial recognition
    • Medzhitov R., and Janeway Jr. C. The Toll receptor family and microbial recognition. Trends Microbiol 8 (2000) 452-456
    • (2000) Trends Microbiol , vol.8 , pp. 452-456
    • Medzhitov, R.1    Janeway Jr., C.2
  • 33
    • 33746312334 scopus 로고    scopus 로고
    • Full-length sequence and expression analysis of Toll-like receptor 9 in the gilthead seabream (Sparus aurata L.)
    • Franch R., Cardazzo B., Antonello J., Castagnaro M., Patarnello T., and Bargelloni L. Full-length sequence and expression analysis of Toll-like receptor 9 in the gilthead seabream (Sparus aurata L.). Gene 378 (2006) 42-51
    • (2006) Gene , vol.378 , pp. 42-51
    • Franch, R.1    Cardazzo, B.2    Antonello, J.3    Castagnaro, M.4    Patarnello, T.5    Bargelloni, L.6
  • 34
    • 0032525023 scopus 로고    scopus 로고
    • CpG Motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species
    • Yi A.-K., Tuetken R., Redford T., Waldschmidt M., Kirsch J., and Krieg A.M. CpG Motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J Immunol 160 (1998) 4755-4761
    • (1998) J Immunol , vol.160 , pp. 4755-4761
    • Yi, A.-K.1    Tuetken, R.2    Redford, T.3    Waldschmidt, M.4    Kirsch, J.5    Krieg, A.M.6
  • 35
    • 0031185042 scopus 로고    scopus 로고
    • The leucocyte population of the unstimulated peritoneal cavity of rainbow trout (Oncorhynchus mykiss)
    • Afonso A., Ellis A.E., and Silva M.T. The leucocyte population of the unstimulated peritoneal cavity of rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol 7 (1997) 335-348
    • (1997) Fish Shellfish Immunol , vol.7 , pp. 335-348
    • Afonso, A.1    Ellis, A.E.2    Silva, M.T.3
  • 36
    • 0032111066 scopus 로고    scopus 로고
    • Uptake of neutrophils and neutrophilic components by macrophages in the inflamed peritoneal cavity of rainbow trout (Oncorhynchus mykiss)
    • Afonso A., Silva J., Lousada S., Ellis A.E., and Silva M.T. Uptake of neutrophils and neutrophilic components by macrophages in the inflamed peritoneal cavity of rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol 8 (1998) 319-338
    • (1998) Fish Shellfish Immunol , vol.8 , pp. 319-338
    • Afonso, A.1    Silva, J.2    Lousada, S.3    Ellis, A.E.4    Silva, M.T.5
  • 37
    • 0036214185 scopus 로고    scopus 로고
    • Immunostimulation of the rainbow trout (Oncorhynchus mykiss) following intraperitoneal administration of ergosan
    • Peddie S., Zou J., and Secombes C.J. Immunostimulation of the rainbow trout (Oncorhynchus mykiss) following intraperitoneal administration of ergosan. Vet Immunol Immunopathol 86 (2002) 101-113
    • (2002) Vet Immunol Immunopathol , vol.86 , pp. 101-113
    • Peddie, S.1    Zou, J.2    Secombes, C.J.3
  • 39
    • 0000386390 scopus 로고
    • Effects of a yeast-cell-wall glucan on the bactericidal activity of rainbow trout macrophages
    • Jørgensen J.B., Sharp G.J.E., Secombes C.J., and Robertsen B. Effects of a yeast-cell-wall glucan on the bactericidal activity of rainbow trout macrophages. Fish Shellfish Immunol 3 (1993) 267-277
    • (1993) Fish Shellfish Immunol , vol.3 , pp. 267-277
    • Jørgensen, J.B.1    Sharp, G.J.E.2    Secombes, C.J.3    Robertsen, B.4
  • 40
    • 0030885073 scopus 로고    scopus 로고
    • The immediate effects of stress on hormones and plasma lysozyme in rainbow trout
    • Demers N.E., and Bayne C.J. The immediate effects of stress on hormones and plasma lysozyme in rainbow trout. Dev Comp Immunol 21 (1997) 363-373
    • (1997) Dev Comp Immunol , vol.21 , pp. 363-373
    • Demers, N.E.1    Bayne, C.J.2
  • 41
    • 0022259091 scopus 로고
    • Immunity to Aeromonas salmonicida in coho salmon (Oncorhynchus kisutch) induced by modified Freund's complete adjuvant: its non-specific nature and the probable role of macrophages in the phenomenon
    • Olivier G., Evelyn T.P.T., and Lallier R. Immunity to Aeromonas salmonicida in coho salmon (Oncorhynchus kisutch) induced by modified Freund's complete adjuvant: its non-specific nature and the probable role of macrophages in the phenomenon. Dev Comp Immunol 9 (1985) 419-432
    • (1985) Dev Comp Immunol , vol.9 , pp. 419-432
    • Olivier, G.1    Evelyn, T.P.T.2    Lallier, R.3
  • 42
    • 0032421440 scopus 로고    scopus 로고
    • Bacterial DNA as immune cell activator
    • Lipford G.B., Heeg K., and Wagner H. Bacterial DNA as immune cell activator. Trends Microbiol 6 (1998) 496-500
    • (1998) Trends Microbiol , vol.6 , pp. 496-500
    • Lipford, G.B.1    Heeg, K.2    Wagner, H.3
  • 43
    • 0030295397 scopus 로고    scopus 로고
    • Protection, immune responses and side effects in Atlantic salmon (Salmo salar L.) vaccinated against furunculosis by different procedures
    • Midtlyng P.J., Reitan L.J., Lillehaug A., and Ramstad A. Protection, immune responses and side effects in Atlantic salmon (Salmo salar L.) vaccinated against furunculosis by different procedures. Fish Shellfish Immunol 8 (1996) 599-613
    • (1996) Fish Shellfish Immunol , vol.8 , pp. 599-613
    • Midtlyng, P.J.1    Reitan, L.J.2    Lillehaug, A.3    Ramstad, A.4
  • 44
    • 0035209654 scopus 로고    scopus 로고
    • Immunostimulatory CpG oligodeoxynucleotides stimulate expression of IL-1β and interferon-like cytokines in rainbow trout macrophages and the stimulatory effect requires endosomal maturation
    • Jørgensen J.B., Zou J., Johansen A., and Secombes C.J. Immunostimulatory CpG oligodeoxynucleotides stimulate expression of IL-1β and interferon-like cytokines in rainbow trout macrophages and the stimulatory effect requires endosomal maturation. Fish Shellfish Immunol 11 (2001) 673-682
    • (2001) Fish Shellfish Immunol , vol.11 , pp. 673-682
    • Jørgensen, J.B.1    Zou, J.2    Johansen, A.3    Secombes, C.J.4
  • 45
    • 0037963680 scopus 로고    scopus 로고
    • Immunostimulatory CpG oligodeoxynucleotides increase resistance against amoebic gill disease in Atlantic salmon, Salmo salar L
    • Brindle A.R., Butler B., and Nowak B.F. Immunostimulatory CpG oligodeoxynucleotides increase resistance against amoebic gill disease in Atlantic salmon, Salmo salar L. J Fish Dis 26 (2003) 367-371
    • (2003) J Fish Dis , vol.26 , pp. 367-371
    • Brindle, A.R.1    Butler, B.2    Nowak, B.F.3
  • 46
    • 0034667770 scopus 로고    scopus 로고
    • Phosphorothioate backbone modification modulates macrophage activation by CpG DNA
    • Sester D.P., Naik S., Beasley S.J., Hume D.A., and Stacey K.J. Phosphorothioate backbone modification modulates macrophage activation by CpG DNA. J Immunol 165 (2000) 4165-4173
    • (2000) J Immunol , vol.165 , pp. 4165-4173
    • Sester, D.P.1    Naik, S.2    Beasley, S.J.3    Hume, D.A.4    Stacey, K.J.5


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