Analysis of the in vitro biocatalytic production of poly-(β)-hydroxybutyric acid

Enzyme and Microbial Technology

Volumn 41, Issue 5, 2007, Pages 591-599

  Burns, Kristi L ^a   Oldham, Charlie D ^a   Thompson, Jeremy R ^a   Lubarsky, Michael ^a   May, Sheldon W ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Biocatalysis; HPLC; Model; Poly ( ) hydroxybutyric acid (PHB); Simulation

Indexed keywords

CARBON ENERGY STORAGE; ENZYMATIC SYNTHESES; POLY HYDROXYBUTYRIC ACID;

BACTERIA; BIODEGRADATION; BIOPOLYMERS; COMPUTER SIMULATION; NUTRIENTS; THERMOPLASTICS; TOXICITY; YEAST;

BIOCATALYSTS;

3 HYDROXYBUTYRATE DEHYDROGENASE; ACETYL COENZYME A; ACETYL COENZYME A ACYLTRANSFERASE; COENZYME A; HYDROXYBUTYRIC ACID; POLY (BETA) HYDROXYBUTRYRIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BIOCATALYST; BIOSYNTHESIS; EXPERIMENTAL STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; KINETICS; NONHUMAN; STOICHIOMETRY; WAUTERSIA EUTROPHA;

CUPRIAVIDUS NECATOR;

EID: 34547520314     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2007.05.003     Document Type: Article

References (42)

1. Fidler S., and Dennis D. Polyhydroxyalkanoate production in recombinant Escherichia coli. FEMS Microbiol Rev 9 (1992) 231-235
2. Gross R.A., and Kalra B. Biodegradable polymers for the environment. Science 297 (2002) 803-807
3. Hocking P.J., and Marchessault R.H. In: Kaplan D.L. (Ed). Biopolymers from Renewable Resources (1998), Springer-Verlag, Berlin, Heidelberg, New York 220-248
4. Lenz R.W., and Marchessault R.H. Bacterial polyesters: biosynthesis, biodegradable plastics and biotechnology. Biomacromolecules 6 (2005) 1-8
5. Wang Y.W., Wu Q., Chen J., and Chen G.Q. Evaluation of three-dimensional scaffolds made of blends of hydroxyapatite and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) for bone reconstruction. Biomaterials 26 (2005) 899-904
6. Salman M.A., Sahin A., Onur M.A., Oge K., Kassab A., and Aypar U. Tramadol encapsulated into polyhydroxybutyrate microspheres: in vitro release and epidural analgesic effect in rats. Acta Anaesthesiol Scand 47 (2003) 1006-1012
7. http://www.metabolix.com/publications/pressreleases.html.
8. Brown S.F. Bioplastic fantastic. Fortune 148 (2003) 92-94
9. Lutke-Eversloh T., Bergander K., Luftmann H., and Steinbuchel A. Identification of a new class of biopolymer: bacterial synthesis of a sulfur-containing polymer with thioester linkages. Microbiology 147 (2001) 11-19
10. Lutke-Eversloh T., Fischer A., Remminghorst U., Kawada J., Marchessault R.H., Bogershausen A., et al. Biosynthesis of novel thermoplastic polythioesters by engineered Escherichia coli. Nat Mater 1 (2002) 236-240
11. Slater S., Houmiel K.L., Tran M., Mitsky T.A., Taylor N.B., Padgette S.R., et al. Multiple beta-ketothiolases mediate poly(beta-hydroxyalkanoate) copolymer synthesis in Ralstonia eutropha. J Bacteriol 180 (1998) 1979-1987
12. Gruys KJ, Mitsky TA, Kishore GM, Slater SC, Padgette SR, Stark DM. Methods of optimizing substrate pools and biosynthesis of hydroxybutyrate-hydroxyvalerate copolymer in bacteria and plants US Patent 5,958,745; 1999.
13. Davis J.T., Moore R.N., Imperiali B., Pratt A.J., Kobayashi K., Masamune S., et al. Biosynthetic thiolase from Zoogloea ramigera. I. Preliminary characterization and analysis of proton transfer reaction. J Biol Chem 262 (1987) 82-89
14. Haywood G.W., Anderson A.J., Chu L., and Dawes E.A. The role of NADH- and NADPH-linked acetoacetyl-CoA reductases in the poly-3-hydroxybutyrate synthesizing organism Alcaligenes eutrophus. FEMS Microbiol Lett 52 (1988) 259-264
15. Song J.J., Zhang S., Lenz R.W., and Goodwin S. In vitro polymerization and copolymerization of 3-hydroxypropionyl-CoA with the PHB synthase from Ralstonia eutropha. Biomacromolecules 1 (2000) 433-439
16. Fukui T., Yoshimoto A., Matsumoto M., Hosokawa S., and Saito T. Enzymatic synthesis of poly-beta-hydroxybutyrate in Zoogloea ramigera. Arch Microbiol 110 (1976) 149-156
17. Mendes P. GEPASI: a software package for modelling the dynamics, steady states and control of biochemical and other systems. Comput Appl Biosci 9 (1993) 563-571
18. Mendes P. Biochemistry by numbers: simulation of biochemical pathways with Gepasi 3. Trends Biochem Sci 22 (1997) 361-363
19. Mendes P., and Kell D. Non-linear optimization of biochemical pathways: applications to metabolic engineering and parameter estimation. Bioinformatics 14 (1998) 869-883
20. Ploux O., Masamune S., and Walsh C.T. The NADPH-linked acetoacetyl-CoA reductase from Zoogloea ramigera. Characterization and mechanistic studies of the cloned enzyme over-produced in Escherichia coli. Eur J Biochem 174 (1988) 177-182
21. Gilbert H.F., Lennox B.J., Mossman C.D., and Carle W.C. The relation of acyl transfer to the overall reaction of thiolase I from porcine heart. J Biol Chem 256 (1981) 7371-7377
22. van Wegen R.J., Lee S.Y., and Middelberg A.P. Metabolic and kinetic analysis of poly(3-hydroxybutyrate) production by recombinant Escherichia coli. Biotechnol Bioeng 74 (2001) 70-80
23. Satoh Y., Tajima K., Tannai H., and Munekata M. Enzyme-catalyzed poly(3-hydroxybutyrate) synthesis from acetate with CoA recycling and NADPH regeneration in vitro. J Biosci Bioeng 95 (2003) 335-341
24. Burns K.L., Gelbaum L.T., Sullards M.C., Bostwick D.E., and May S.W. Iso-coenzyme A. J Biol Chem 280 (2005) 16550-16558
25. Leaf T.A., and Srienc F. Metabolic modeling of polyhydroxybutyrate biosynthesis. Biotechnol Bioeng 57 (1998) 557-570
26. Daae E.B., Dunnill P., Mitsky T.A., Padgette S.R., Taylor N.B., Valentin H.E., et al. Metabolic modeling as a tool for evaluating polyhydroxyalkanoate copolymer production in plants. Metab Eng 1 (1999) 243-254
27. Saito T., Fukui T., Ikeda F., Tanaka Y., and Tomita K. An NADP-linked acetoacetyl CoA reductase from Zoogloea ramigera. Arch Microbiol 114 (1977) 211-217
28. DeBuysere M.S., and Olson M.S. The analysis of acyl-coenzyme A derivatives by reverse-phase high-performance liquid chromatography. Anal Biochem 133 (1983) 373-379
29. Claessens H.A., vanStraten M.A., and Kirkland J.J. Effect of buffers on silica-based column stability in reversed-phase high-performance liquid chromatography. J Chromatogr A 728 (1996) 259-270
30. Lynen F., and Ochoa S. Enzymes of fatty acid metabolism. Biochim Biophys Acta 12 (1953) 299-314
31. Anderson V.E., Bahnson B.J., Wlassics I.D., and Walsh C.T. The reaction of acetyldithio-CoA, a readily enolized analog of acetyl-CoA with thiolase from Zoogloea ramigera. J Biol Chem 265 (1990) 6255-6261
32. Thompson S., Mayerl F., Peoples O.P., Masamune S., Sinskey A.J., and Walsh C.T. Mechanistic studies on beta-ketoacyl thiolase from Zoogloea ramigera: identification of the active-site nucleophile as Cys89, its mutation to Ser89, and kinetic and thermodynamic characterization of wild-type and mutant enzymes. Biochemistry 28 (1989) 5735-5742
33. Wakil S.J., Green D.E., Mii S., and Mahler H.R. Studies on the fatty acid oxidizing system of animal tissues. VI. beta-Hydroxyacyl coenzyme A dehydrogenase. J Biol Chem 207 (1954) 631-638
34. Zhang S., Yasuo T., Lenz R.W., and Goodwin S. Kinetic and mechanistic characterization of the polyhydroxybutyrate synthase from Ralstonia eutropha. Biomacromolecules 1 (2000) 244-251
35. Zhang S., Kolvek S., Lenz R.W., and Goodwin S. Mechanism of the polymerization reaction initiated and catalyzed by the polyhydroxybutyrate synthase of Ralstonia eutropha. Biomacromolecules 4 (2003) 504-509
36. Voet D., and Voet J.G. In: Harris D., and Fitzgerald P. (Eds). Biochemistry. 3rd ed. (2004), John Wiley & Sons, Hoboken, NJ 929
37. Yao K.W., and Schulz H. Intermediate channeling on the trifunctional beta-oxidation complex from pig heart mitochondria. J Biol Chem 271 (1996) 17816-17820
38. Beun J.J., Verhoef E.V., Van Loosdrecht M.C., and Heijnen J.J. Stoichiometry and kinetics of poly-beta-hydroxybutyrate metabolism under denitrifying conditions in activated sludge cultures. Biotechnol Bioeng 68 (2000) 496-507
39. Yu J., Si Y., and Wong W.-K.R. Kinetics modeling of inhibition and utilization of mixed volatile fatty acids in the formation of polyhydroxyalkanoates by Ralstonia eutropha. Process Biochem 37 (2002) 731-738
40. Carlson R., Fell D., and Srienc F. Metabolic pathway analysis of a recombinant yeast for rational strain development. Biotechnol Bioeng 79 (2002) 121-134
41. Third K.A., Newland M., and Cord-Ruwisch R. The effect of dissolved oxygen on PHB accumulation in activated sludge cultures. Biotechnol Bioeng 82 (2003) 238-250
42. Haywood G.W., Anderson A.J., Chu L., and Dawes E.A. Characterization of two 3-ketothiolases possessing differing substrate specificities in the polyhydroxyalkanoate synthesizing organism Alcaligenes eutrophus. FEMS Microbiol Lett 52 (1988) 91-96