Metabolically labile cannabinoid esters: A 'soft drug' approach for the development of cannabinoid-based therapeutic drugs

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 17, 2007, Pages 4878-4881

  Minutolo, F ^a   Cascio, M G ^b   Carboni, I ^a   Bisogno, T ^b   Prota, G ^a   Bertini, S ^a   Digiacomo, M ^a   Bifulco, M ^c   Di Marzo, V ^b   Macchia, M ^a  

^a UNIVERSITY OF PISA   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

Author keywords

Cannabinoids; CB1; CB2; Retrometabolic; Soft drugs

Indexed keywords

CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CARBOXYLIC ACID; ESTER DERIVATIVE; POTASSIUM;

ARTICLE; BINDING AFFINITY; DEMETHYLATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS;

ANALGESICS; ANIMALS; CANNABINOIDS; CARBOXYLIC ACIDS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ESTERS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LIGANDS; LIVER; MODELS, CHEMICAL; RATS; RECEPTORS, CANNABINOID;

EID: 34547496849     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.06.055     Document Type: Article

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12. +).
13. +).
14. 3, 200 MHz) δ 2.36 (s, 6H), 3.81 (s, 6H), 6.94 (s, 1H), 6.98 (s, 2H), 7.41 (s, 2H).
15. 3, 200 MHz) δ 2.30 (s, 6H), 3.76 (s, 3H), 6.93 (m, 3H), 7.22 (d, 1H, J = 1.3 Hz), 7.33 (d, 1H, J = 1.3 Hz), 8.09 (br s, 2H).
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