Enhanced protective efficacy and reduced viral load of foot-and-mouth disease DNA vaccine with co-stimulatory molecules as the molecular adjuvants

Antiviral Research

Volumn 76, Issue 1, 2007, Pages 11-20

  Xiao, Chong ^a   Jin, Huali ^a   Hu, Yanxin ^b   Kang, Youmin ^a   Wang, Junpeng ^a   Du, Xiaogang ^a   Yang, Yu ^a   She, Ruiping ^b   Wang, Bin ^a  

^a AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

^b CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

4 1BBL; Cell mediated immune responses; Co stimulatory molecules; FMDV DNA vaccine; in vivo CTL; Neutralizing antibody; OX40L; Protection; Viral load

Indexed keywords

CD134 ANTIGEN; CD137 LIGAND; DNA VACCINE; FOOT AND MOUTH DISEASE VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; PROTEIN VP1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DNA IMMUNIZATION; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; FOOT AND MOUTH DISEASE; GUINEA PIG; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS LOAD;

4-1BB LIGAND; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY TESTS, IMMUNOLOGIC; FEMALE; FOOT-AND-MOUTH DISEASE; FOOT-AND-MOUTH DISEASE VIRUS; GUINEA PIGS; HELA CELLS; HUMANS; IMMUNOGLOBULIN G; INJECTIONS, INTRAMUSCULAR; INTERFERON TYPE II; MICE; MICE, INBRED BALB C; NEUTRALIZATION TESTS; OX40 LIGAND; VACCINATION; VACCINES, DNA; VIRAL LOAD; VIRAL VACCINES;

ANIMALIA; FOOT-AND-MOUTH DISEASE VIRUS;

EID: 34547471034     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2007.04.002     Document Type: Article

References (38)

1. Akahata W., Ido E., Akiyama H., Uesaka H., Enose Y., Horiuchi R., Kuwata T., Goto T., Takahashi H., and Hayami M. DNA vaccination of macaques by a full-genome simian/human immunodeficiency virus type 1 plasmid chimera that produces non-infectious virus particles. J. Gen. Virol. 84 (2003) 2237-2244
2. Alexandersen S., Zhang Z., and Donaldson A.I. Aspects of the persistence of foot-and-mouth disease virus in animals-the carrier problem. Microbes Infect. 4 (2002) 1099-1110
3. Boyer J.D., Cohen A.D., Vogt S., Schumann K., Nath B., Ahn L., Lacy K., Bagarazzi M.L., Higgins T.J., Baine Y., Ciccarelli R.B., Ginsberg R.S., MacGregor R.R., and Weiner D.B. Vaccination of seronegative volunteers with a human immunodeficiency virus type 1 env/rev DNA vaccine induces antigen-specific proliferation and lymphocyte production of beta-chemokines. J. Infect. Dis. 181 (2000) 476-483
4. Brown F. New approaches to vaccination against foot-and-mouth disease. Vaccine 10 (1992) 1022-1026
5. Bukczynski J., Wen T., Ellefsen K., Gauldie J., and Watts T.H. Costimulatory ligand 4-1BBL (CD137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses. PNAS 101 (2004) 1291-1296
6. Cedillo-Barron L., Foster-Cuevas M., Belsham G.J., Lefevre F., and Parkhouse R.M.E. Induction of a protective response in swine vaccinated with DNA encoding foot-and-mouth disease virus empty capsid proteins and the 3D RNA polymerase. J. Gen. Virol. 82 (2001) 1713-1724
7. Childerstone A.J., Cedillo-Baron L., Foster-Cuevas M., and Parkhouse R.M. Demonstration of bovine CD8+ T-cell responses to foot-and-mouth disease virus. J. Gen. Virol. 80 (1999) 663-669
8. Collen T. Foot-and-mouth disease (aphthovirus): viral T cell epitopes. In: Goodeevis B.M.L., and Morrison I. (Eds). Cell Mediated Immunity in Ruminants (1994), CRC Press Inc. 173-197
9. Du X., Zheng G., Jin H., Kang Y., Wang J., Xiao C., Zhang S., Liu M., Zhao L., Chen A., and Wang B. Effect of the Co-stimulatory molecules, 4-1BBL, OX40L and CD70, as adjuvants on the cellular and memory responses on HBsAg DNA vaccination. J. Gene Med. 9 (2007) 136-146
10. Ferris N.P., Kitching R.P., Oxtoby J.M., Philpot R.M., and Rendle R. Use of inactivated foot-and-mouth disease virus antigen in liquid-phase blocking ELISA. J. Virol. Methods 29 (1990) 33-41
11. Fynan E.F., Webster R.G., Fuller D.H., Haynes J.R., Santoro J.C., and Robinson H.L. DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. PNAS 90 (1993) 11478-11482
12. Garcia-Briones M.M., Blanco E., Chiva C., Andreu D., Ley V., and Sobrino F. Immunogenicity and T cell recognition in swine of foot-and-mouth disease virus polymerase 3D. Virology 322 (2004) 264-275
13. Gramaglia I., Cooper D., Miner K.T., Kwon B.S., and Croft M. Co-stimulation of antigen-specific CD4 T cells by 4-1BB ligand. Eur. J. Immunol. 30 (2000) 392-402
14. Grubman M.J., and Baxt B. Foot-and-mouth disease. Clin. Microbiol. Rev. 17 (2004) 465-493
15. Guinn B., DeBenedette M.A., Watts T.H., and Berinstein N.L. 4-1BBL cooperates with B7-1 and B7-2 in converting a B Cell lymphoma cell line into a long-lasting antitumor vaccine. J. Immunol. 162 (1999) 5003-5010
16. Guo H., Liu Z., Sun S., Bao H., Chen Y., Liu X., and Xie Q. Immune response in guinea pigs vaccinated with DNA vaccine of foot-and-mouth disease virus O/China99. Vaccine 23 (2005) 3236-3242
17. Hamblin C., Barnett I.T., and Hedger R.S. A new enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies against foot-and-mouth disease virus. I. Development and method of ELISA. J. Immunol. Methods 93 (1986) 115-121
18. Ishii N., Ndhlovu L.C., Murata K., Sato T., Kamanaka M., and Sugamura K. OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses. Eur. J. Immunol. 33 (2003) 2372-2381
19. Jin H., Li Y., Ma Z., Zhang F., Xie Q., Gu D., and Wang B. Effect of chemical adjuvants on DNA vaccination. Vaccine 22 (2004) 2925-2935
20. Jin H., Xiao C., Chen Z., Kang Y., Ma Y., Zhu K., Xie Q., Tu Y., Yu Y., and Wang B. Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice. Biochem. Biophys. Res. Commun. 328 (2005) 979-986
21. Kawahara T., Kuwano Y., Teshima-Kondo S., Takeya R., Sumimoto H., Kishi K., Tsunawaki S., Hirayama T., and Rokutan K. Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to toll-like receptor 5 signaling in large intestinal epithelial cells. J. Immunol. 172 (2004) 3051-3058
22. Kim J.J., Maguire H.C., Nottingham L.K., Morrison L.D., Tsai A., Sin J.I., Chalian A.A., and Weiner D.B. Coadministration of IL-12 or IL-10 expression cassettes drives immune responses toward a Th1 phenotype. J. Interferon Cytokine Res. 18 (1998) 537-547
23. McCullough K., and Sobrino F. Immunology of foot-and-mouth disease virus. In: McCullough K., and Sobrino F. (Eds). Foot-and-Mouth Disease Virus, Current Perspectives (2004), Horizon Scientific Press, UK 173-222
24. McVicar J.W., and Sutmoller P. The epizootiological importance of foot-and-mouth disease carriers II. The carrier status of cattle exposed to foot-and-mouth disease following vaccination with an oil adjuvant inactivated virus vaccine. Arch. Gesamte. Virusforsch. 26 (1969) 217-224
25. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63
26. Pereira, H.G., 1981. Virus diseases of food animals. Foot-and-mouth disease, 333-363.
27. Piriou L., Chilmonczyk S., Genetet N., and Albina E. Design of a flow cytometric assay for the determination of natural killer and cytotoxic T-lymphocyte activity in human and in different animal species. Cytometry 41 (2000) 289-297
28. Sambrook J., Fritsch E., and Maniatis T. Molecular cloning: a laboratory manual (1989), Cold Spring Harbor Laboratory Press, New York
29. Sanz-Parra A., Jimenez-Clavero M.A., Garcia-Briones M.M., Blanco E., Sobrino F., and Ley V. Recombinant viruses expressing the foot-and-mouth disease virus capsid precursor polypeptide (P1) induce cellular but not humoral antiviral immunity and partial protection in pigs. Virology 259 (1999) 129-134
30. Serghides L., Bukczynski J., Wen T., Wang C., Routy J.-P., Boulassel M.-R., Sekaly R.-P., Ostrowski M., Bernard N.F., and Watts T.H. Evaluation of OX40 Ligand as a Costimulator of Human Antiviral Memory CD8 T Cell Responses: Comparison with B7.1 and 4-1BBL. J. Immunol. 175 (2005) 6368-6377
31. Sobrino F., and Domingo E. Foot-and-mouth disease in Europe. FMD is economically the most important disease of farm animals. Its re-emergence in Europe is likely to have consequences that go beyond severe alterations of livestock production and trade. EMBO Rep. 2 (2001) 459-461
32. Srivastava I.K., and Liu M.A. Gene Vaccines. Ann. Intern. Med. 138 (2003) 550-559
33. Svanholm C., Lowenadler B., and Wigzell H. Amplification of T-cell and antibody responses in DNA-based immunization with HIV-1 Nef by co-injection with a GM-CSF expression vector. Scand. J. Immunol. 46 (1997) 298-303
34. Tacket C.O., Roy M.J., Widera G., Swain W.F., Broome S., and Edelman R. Phase 1 safety and immune response studies of a DNA vaccine encoding hepatitis B surface antigen delivered by a gene delivery device. Vaccine 17 (1999) 2826-2829
35. Tu Yixian Z.X., Kaichun Z., Hualix H., Fux F., Fuchun Z., and Bin W. Comparisons of the efficiency of CSFV E2 gene DNA vaccine in two different eukaryotic vectors. J. China Agric. Univ. 6 (2005) 37-41
36. Ulmer J.B., Donnelly J.J., Parker S.E., Rhodes G.H., Felgner P.L., Dwarki V.J., Gromkowski S.H., Deck R.R., DeWitt C.M., Friedman A., et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259 (1993) 1745-1749
37. Wang B., Merva M., Dang K., Ugen K.E., Williams W.V., and Weiner D.B. Immunization by direct DNA inoculation induces rejection of tumor cell challenge. Hum. Gene Ther. 6 (1995) 407-418
38. Wang B., Ugen K.E., Srikantan V., Agadjanyan M.G., Dang K., Refaeli Y., Sato A.I., Boyer J., Williams W.V., and Weiner D.B. Gene inoculation generates immune responses against human immunodeficiency virus type 1. PNAS 90 (1993) 4156-4160