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Volumn 9, Issue 14, 2007, Pages 2701-2704

Benzothiazines in organic synthesis. the preparation of enantiomerically pure 4-substituted quinolones

Author keywords

[No Author keywords available]

Indexed keywords

ESTER; QUINOLONE DERIVATIVE; THIAZINE DERIVATIVE;

EID: 34547421292     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0710358     Document Type: Article
Times cited : (45)

References (34)
  • 1
    • 84944053662 scopus 로고    scopus 로고
    • Katritzky, A. R, Rees, C. W, Scriven, E. F. V, Eds, Pergamon Press: Oxford, UK
    • (a) Jones, G. In Comprehensive Heterocyclic Chemistry II; Katritzky, A. R., Rees, C. W., Scriven, E. F. V., Eds.; Pergamon Press: Oxford, UK, 1996; p 167.
    • (1996) Comprehensive Heterocyclic Chemistry II , pp. 167
    • Jones, G.1
  • 15
    • 0000324847 scopus 로고
    • Boulton, A. J, McKillop, A, Eds, Pergamon Press: Oxford, UK
    • (j) Jones G. In Comprehensive Heterocyclic Chemistry; Boulton, A. J., McKillop, A., Eds.; Pergamon Press: Oxford, UK, 1984; Vol. 2 (8).
    • (1984) Comprehensive Heterocyclic Chemistry , vol.2 , Issue.8
    • Jones, G.1
  • 32
    • 34547484628 scopus 로고    scopus 로고
    • Allylation of Hf resulted in only a 5.1:1 mixture of the isomers of 17c (entry 3, Table 2).
    • Allylation of Hf resulted in only a 5.1:1 mixture of the isomers of 17c (entry 3, Table 2).
  • 33
    • 34547458858 scopus 로고    scopus 로고
    • We are assuming the dihydroquinolones are as enantiomerically pure as the sulfoximine 6, which is used to prepare the benzothiazine precursors of the quinolones. The resolution of 6 is performed according to Gais 11 and the enantiomeric purity of the sulfoxime is checked by chiral column chromatography. We prepared enantiomerically pure 12a and compared it to racemic material by chiral HPLC to validate this assumption
    • 11 and the enantiomeric purity of the sulfoxime is checked by chiral column chromatography. We prepared enantiomerically pure 12a and compared it to racemic material by chiral HPLC to validate this assumption.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.