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Allylation of Hf resulted in only a 5.1:1 mixture of the isomers of 17c (entry 3, Table 2).
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Allylation of Hf resulted in only a 5.1:1 mixture of the isomers of 17c (entry 3, Table 2).
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33
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We are assuming the dihydroquinolones are as enantiomerically pure as the sulfoximine 6, which is used to prepare the benzothiazine precursors of the quinolones. The resolution of 6 is performed according to Gais 11 and the enantiomeric purity of the sulfoxime is checked by chiral column chromatography. We prepared enantiomerically pure 12a and compared it to racemic material by chiral HPLC to validate this assumption
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11 and the enantiomeric purity of the sulfoxime is checked by chiral column chromatography. We prepared enantiomerically pure 12a and compared it to racemic material by chiral HPLC to validate this assumption.
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