Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 14, 2001, Pages 1943-1945

  Patel, Mona ^a,b   McHugh Jr , Robert J ^a   Cordova, Beverly C ^a   Klabe, Ronald M ^a   Bacheler, Lee T ^a   Erickson Viitanen, Susan ^a   Rodgers, James D ^a  

^a DUPONT COMPANY   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; EFAVIRENZ; KETONE DERIVATIVE; QUINOLINONE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; REACTION ANALYSIS; VIRUS MUTANT;

ANTIVIRAL AGENTS; DRUG RESISTANCE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; INHIBITORY CONCENTRATION 50; MUTATION; QUINOLONES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0035939374     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00331-6     Document Type: Article

References (9)