Human chorionic gonadotropin prevents Sjögren's syndrome-like exocrinopathy in mice

Arthritis and Rheumatism

Volumn 56, Issue 7, 2007, Pages 2211-2215

  Li, Na ^a   Shigihara, Toshikatsu ^a   Tzioufas, Athanasios G ^b   Notkins, Abner L ^b   Yoon, Ji Won ^d   Jun, Hee Sook ^a,c  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^c ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; CYTOKINE; GAMMA INTERFERON; GELATINASE B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; MESSENGER RNA; PHOSPHATE BUFFERED SALINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; EXOCRINE GLAND; EXOCRINE GLAND MALFORMATION; FEMALE; FLOW RATE; HISTOPATHOLOGY; IMMUNOMODULATION; LACRIMAL GLAND; LYMPHOCYTE PROLIFERATION; MEASUREMENT; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PLANT PARENCHYMA CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SALIVARY GLAND; SALIVATION; SJOEGREN SYNDROME; SJOGREN SYNDROME LIKE EXOCRINOPATHY; SUBMANDIBULAR GLAND;

ANIMALS; CHORIONIC GONADOTROPIN; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; INFLAMMATION; INTERFERON TYPE II; INTERLEUKIN-4; MICE; MICE, INBRED NOD; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SALIVA; SALIVARY GLANDS; SJOGREN'S SYNDROME;

EID: 34547400100     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.22737     Document Type: Article

References (24)

1. Tapinos NI, Polihronis M, Tzioufas AG, Moutsopoulos HM. Sjögren's syndrome: autoimmune epithelitis [review]. Adv Exp Med Biol 1999;455:127-34.
2. Cha S, Peck AB, Humphreys-Beher MG. Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update. Crit Rev Oral Biol Med 2002;13:5-16.
3. Whitacre CC. Sex differences in autoimmune disease. Nat Immunol 2001;2:777-80.
4. Bao M, Yang Y, Jun HS, Yoon JW. Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Immunol 2002;168: 5369-75.
5. Ascoli M, Fanelli F, Segaloff DL. The lutropin/choriogonadotropin receptor: a 2002 perspective [review]. Endocr Rev 2002;23: 141-74.
6. Kayisli UA, Selam B, Guzeloglu-Kayisli O, Demir R, Arici A. Human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating Fas-Fas ligand system. J Immunol 2003;171:2305-13.
7. Song XY, Zeng L, Jin W, Pilo CM, Frank ME, Wahl SM. Suppression of streptococcal cell wall-induced arthritis by human chorionic gonadotropin. Arthritis Rheum 2000;43:2064-72.
8. Khan NA, Khan A, Savelkoul HF, Benner R. Inhibition of diabetes in NOD mice by human pregnancy factor. Hum Immunol 2001;62:1315-23.
9. Jun HS, KM LY, Kwon H, Kim S, Sun B, Notkins AL, et al. Human choriogonadotropin can prevent autoimmune diabetes in NOD mice. Diabetes 2001;50 Suppl 2:A260.
10. Ishimaru N, Yoneda T, Saegusa K, Yanagi K, Haneji N, Moriyama K, et al. Severe destructive autoimmune lesions with aging in murine Sjögren's syndrome through Fas-mediated apoptosis. Am J Pathol 2000;156:1557-64.
11. Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000;132:365-86.
12. -ΔΔCTmethod. Methods 2001;25:402-8.
13. Perez P, Kwon YJ, Alliende C, Leyton L, Aguilera S, Molina C, et al. Increased acinar damage of salivary glands of patients with Sjögren's syndrome is paralleled by simultaneous imbalance of matrix metalloproteinase 3/tissue inhibitor of metalloproteinases 1 and matrix metalloproteinase 9/tissue inhibitor of metalloproteinases 1 ratios. Arthritis Rheum 2005;52:2751-60.
14. Devoto L, Kohen P, Vega M, Castro O, Gonzalez RR, Retamales I, et al. Control of human luteal steroidogenesis. Mol Cell Endocrinol 2002;186:137-41.
15. Filicori M, Fazleabas AT, Huhtaniemi I, Licht P, Rao ChV, Tesarik J, et al. Novel concepts of human chorionic gonadotropin: reproductive system interactions and potential in the management of infertility. Fertil Steril 2005;84:275-84.
16. Komorowski J, Gradowski G, Stepien H. Effects of human chorionic gonadotropin (hCG) and β-hCG on oncostatin M release from human peripheral blood mononuclear cells in vitro. Cytobios 1997;92:159-63.
17. Rao CV. An overview of the past, present, and future of nongonadal LH/hCG actions in reproductive biology and medicine [editorial]. Semin Reprod Med 2001;19:7-17.
18. Kaaja RJ, Greer IA. Manifestations of chronic disease during pregnancy. JAMA 2005;294:2751-7.
19. Gill PS, Lunardi-Ishkandar Y, Louie S, Tulpule A, Zheng T, Espina BM, et al. The effects of preparations of human chorionic gonadotropin on AIDS-related Kaposi's sarcoma. N Engl J Med 1996;335:1261-9.
20. Pfeffer U, Bisacchi D, Morini M, Benelli R, Minghelli S, Vacca A, et al. Human chorionic gonadotropin inhibits Kaposi's sarcoma associated angiogenesis, matrix metalloprotease activity, and tumor growth. Endocrinology 2002;143:3114-21.
21. De SK, Devadas K, Notkins AL. Elevated levels of tumor necrosis factor α (TNF-α) in human immunodeficiency virus type 1-transgenic mice: prevention of death by antibody to TNF-α. J Virol 2002;76:11710-4.
22. Tapia-Serrano R, Jimenez-Balderas FJ, Murrieta S, Bravo-Gatica C, Guerra R, Mintz G. Testicular function in active ankylosing spondylitis: therapeutic response to human chorionic gonadotrophin. J Rheumatol 1991;18:841-8.
23. Manna SK, Mukhopadhyay A, Aggarwal BB. Human chorionic gonadotropin suppresses activation of nuclear transcription factor-κB and activator protein-1 induced by tumor necrosis factor. J Biol Chem 2000;275:13307-14.
24. Rao CV, Li X, Manna SK, Lei ZM, Aggarwal BB. Human chorionic gonadotropin decreases proliferation and invasion of breast cancer MCF-7 cells by inhibiting NF-κB and AP-1 activation. J Biol Chem 2004;279:25503-10.