Reagents for astatination of biomolecules. 2. Conjugation of anionic boron cage pendant groups to a protein provides a method for direct labeling that is stable to in vivo deastatination

Bioconjugate Chemistry

Volumn 18, Issue 4, 2007, Pages 1226-1240

  Wilbur, D Scott ^a   Chyan, Ming Kuan ^a   Hamlin, Donald K ^a   Vessella, Robert L ^a   Wedge, Timothy J ^b   Hawthorne, M Frederick ^b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; BORON; MONOCLONAL ANTIBODIES; SODIUM COMPOUNDS; STABILITY;

ANTIBODY FAB′-FRAGMENTS; BIODISTRIBUTIONS; CARBORANES; CHLORAMINE-T; CLOSO-DECABORATE; DIRECT LABELLING; IN-VIVO; PENDANT GROUPS; RADIOCHEMICAL YIELD; TISSUE DISTRIBUTIONS;

ESTERS;

ANION; ANTIBODY CONJUGATE; ASTATINE 211; BORON DERIVATIVE; CARBORANE DERIVATIVE; ESTER DERIVATIVE; IMMUNOGLOBULIN F(AB) FRAGMENT; IODINE 125; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROTEIN; SODIUM DERIVATIVE; TOSYLCHLORAMIDE SODIUM; TRACER;

ALPHA RADIATION; ANIMAL TISSUE; ARTICLE; ASTATINATION; CHEMICAL REACTION; CONJUGATE; CONJUGATION; CONTROLLED STUDY; DEASTATINATION; IN VIVO STUDY; ISOTOPE LABELING; MOLECULAR STABILITY; MOUSE; NONHUMAN; PROTEIN METABOLISM; QUANTUM YIELD; RADIOACTIVITY; RADIOCHEMISTRY; TISSUE DISTRIBUTION;

DIONAEA; MUS;

EID: 34547379205     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc060345s     Document Type: Article

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