Trifunctional conjugation reagents. Reagents that contain a biotin and a radiometal chelation moiety for application to extracorporeal affinity adsorption of radiolabeled antibodies

Bioconjugate Chemistry

Volumn 13, Issue 5, 2002, Pages 1079-1092

  Wilbur, D Scott ^a   Chyan, Ming Kuan ^a   Hamlin, Donald K ^a   Kegley, Brian B ^a   Nilsson, Rune ^b   Sandberg, Bengt E B ^b   Brechbiel, Martin ^c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b Mitra Medical AB   (Sweden)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BLOOD; CARBOXYLATION; COENZYMES; FUNCTION EVALUATION; MONOCLONAL ANTIBODIES; STABILITY; SURFACE PLASMON RESONANCE;

AFFINITY ADSORPTION; ANTIGEN BINDING; BIOTINYLATIONS; CELL-BINDING; DELETERIOUS EFFECTS; IMMUNOREACTIVITIES; MINIMIZING THE NUMBER OF; RADIOIODINATION; RADIOLABELLING; WATERSOLUBLE;

CHELATION;

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; 1,4,7,10-TETRAAZACYCLODODECANE- 1,4,7,10-TETRAACETIC ACID; ANTIBODY CONJUGATE; AVIDIN; BIOTIN; CHELATING AGENT; CROSS LINKING REAGENT; INDIUM; PENTETIC ACID; SINGLE HETEROCYCLIC RINGS; YTTRIUM;

AFFINITY CHROMATOGRAPHY; AFFINITY LABELING; ARTICLE; CELL CULTURE; CHEMISTRY; DRUG STABILITY; EXTRACORPOREAL CIRCULATION; HUMAN; METHODOLOGY;

AFFINITY LABELS; AVIDIN; BIOTIN; CHELATING AGENTS; CHROMATOGRAPHY, AFFINITY; CROSS-LINKING REAGENTS; DRUG STABILITY; EXTRACORPOREAL CIRCULATION; HETEROCYCLIC COMPOUNDS, 1-RING; HUMANS; IMMUNOCONJUGATES; INDIUM RADIOISOTOPES; PENTETIC ACID; TUMOR CELLS, CULTURED; YTTRIUM RADIOISOTOPES;

EID: 0036740028     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc025535r     Document Type: Article

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