Tet-on induction with doxycycline after gene transfer in mice: Sweetening of drinking water is not a good idea

Animal Biotechnology

Volumn 18, Issue 3, 2007, Pages 183-188

  Hojman, Pernille ^a   Eriksen, Jens ^a   Gehl, Julie ^a  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Doxycycline; Electroporation; Gene expression; Mice; Sucrose; Tet On system

Indexed keywords

GENE EXPRESSION; MAMMALS; MUSCLE; POTABLE WATER; SUGAR (SUCROSE);

DOXYCYCLINES; ELECTROPORATION; ELECTROTRANSFERRED GENES; MICE;

GENE TRANSFER;

MUS;

DOXYCYCLINE; ERYTHROPOIETIN; SUCROSE;

ANIMAL; ARTICLE; C57BL MOUSE; DRINKING; DRUG EFFECT; EATING; ELECTROPORATION; FEMALE; GENE TRANSFER; GENETICS; METHODOLOGY; MOUSE; PHYSIOLOGY; SKELETAL MUSCLE;

ANIMALS; DOXYCYCLINE; DRINKING; EATING; ELECTROPORATION; ERYTHROPOIETIN; FEMALE; GENE TRANSFER TECHNIQUES; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; SUCROSE;

EID: 34547264353     PISSN: 10495398     EISSN: 15322378     Source Type: Journal    
DOI: 10.1080/10495390601105055     Document Type: Article

References (14)

1. Mir LM, Moller PH, Andre F, Gehl J. Electric pulse-mediated gene delivery to various animal tissues. Advances in Genetics 2005; 54: 83-114.
2. Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, Bujard H. Transcriptional "activation by tetracyclines in mammalian cells. Science 1995; 268:1766-1769.
3. Kistner A, Gossen M, Zimmermann F, Jerecic J, Ullmer C, Lübbert H, Bujard H. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. PNAS 1996; 93:10933-10938.
4. Lamartina S, Roscilli G, Rinaudo CD, Sporeno E, Silvi L, Hillen W, Bujard H, Cortese R, Ciliberto G, Toniatti C. Stringent control of gene expression in vivo by using novel doxycycline-dependent transactivators. Hum Gene Ther 2002; 13:199-210.
5. Rendahl KG, Quiroz D, Ladner M, Coyne M, Seltzer J, Manning WC, Escobedo JA. Tightly regulated long-term erythropoietin expression in vivo using tet-inducible recombinant adeno-associated viral vectors. Hum Gene Ther 2002; 13:335-342.
6. Toniatti C, Bujard H, Cortese R, Ciliberto G. Gene therapy progress and prospects: "Transcription regulatory systems. Gene Ther. 2004; 11:649-657.
7. Rizzuto G, Cappelletti M, Maione D, Savino R, Lazzaro D, Costa P, Mathiessen I, Cortese R, Ciliberto G, Laufer R, La Monica N, Fattori E. Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation. PNAS 1999; 96:6417-6422.
8. Martel-Renoir D, Trochon-Joseph V, Galaup A, Bouquet C, Griscelli F, Opolon P, Opolon D, Connault E, Mir L, Perricaudet M. Coelectrotransfer to skeletal muscle of three plasmids coding for antiangiogenic factors and regulatory factors of the tetracycline-inducible system: Tightly regulated expression, inhibition of transplanted tumor growth, and antimetastatic effect. Mol Ther 2003; 8:425-433.
9. Lamartina S, Silvi L, Roscilli G, Casimiro D, Simon AJ, Davies ME, Shiver JW, Rinaudo CD, Zampaglione I, Fattori E, Collaca S, Gonzalez Paz O, Bujard H, Cortese R, Ciliberto G, Toniatti C. Construction of an rtTA2s-m2/ttskid-Based transcription regulatory switch that displays no basal activity, good inducdbility, and high responsiveness to doxycycline in mice and non-human primates. Mol Ther 2003; 7:271-280.
10. Gronevik E, Mathiesen I, Lomo T. Early events of electroporation-mediated intramuscular DNA vaccination potentiate Thl-directed immune responses. J Gene Med 2005; 7:1246-1254.
11. Gallagher AR, Schönig K, Brown N, Bujard H, Witzgall R. Use of the tetracycline systemn for inducible protein synthesis in the kidney J Am Soc Nephrol. 2003; 14:2042-2051.
12. Richard P, Pollard H, Lanctin C et al. Inducible production of erythropoietin using intramuscular injection of block copolymer/DNA formulation. J Gene Med 2005; 7:80-86.
13. Grill MA, Bales MA, Fought AN, Rosburg KC, Munger SJ, Antin PB. Tetracycline-inducible system for regulation of skeletal muscle-specific gene expression in transgenic mice. Transgenic Research 2003; 12:33-43.
14. Perez N, Plence P, Millet V, Greuet D, Minot C, Noel D, Danos O, Jorgensen C, Apparailly F. Tetracycline transcriptional silencer tightly controls transgene expression after in vivo intramuscular electrotransfer: Application to interleukin 10 therapy in experimental arthritis. Hum Gene Ther 2002; 13:2161-2172.