메뉴 건너뛰기




Volumn 17, Issue 7, 2007, Pages 627-637

Downregulation of CD4+CD25+ regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells

Author keywords

Anti CD25 antibody; CD4+CD25+Foxp3+ Treg; Immunization with activated autologous T cells; Serum adoptive transfer

Indexed keywords

ANTISERUM; CD4 ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2 RECEPTOR ALPHA; UNCLASSIFIED DRUG;

EID: 34547194328     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2007.46     Document Type: Article
Times cited : (30)

References (45)
  • 1
    • 27544506907 scopus 로고    scopus 로고
    • High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients
    • Schmitz-Winnenthal FH, Volk C, Z'graggen K, et al. High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients. Cancer Res 2005; 65:10079-10087.
    • (2005) Cancer Res , vol.65 , pp. 10079-10087
    • Schmitz-Winnenthal, F.H.1    Volk, C.2    Z'graggen, K.3
  • 2
    • 27544493547 scopus 로고    scopus 로고
    • Tumor cell loaded type1 polarized dendritic cells induce Th1-mediated tumor immunity
    • Hokey DA, Larregina AT, Erdos G, et al. Tumor cell loaded type1 polarized dendritic cells induce Th1-mediated tumor immunity. Cancer Res 2005; 65:10059-10067.
    • (2005) Cancer Res , vol.65 , pp. 10059-10067
    • Hokey, D.A.1    Larregina, A.T.2    Erdos, G.3
  • 3
    • 22544433708 scopus 로고    scopus 로고
    • Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27
    • Morishima N, Owaki T, Asakawa M, et al. Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27. J Immunol 2005; 175:1686-1693.
    • (2005) J Immunol , vol.175 , pp. 1686-1693
    • Morishima, N.1    Owaki, T.2    Asakawa, M.3
  • 4
    • 0032418812 scopus 로고    scopus 로고
    • The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses
    • Kalams SA, Walker BD. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J Exp Med 1998; 188:2199- 2204.
    • (1998) J Exp Med , vol.188 , pp. 2199-2204
    • Kalams, S.A.1    Walker, B.D.2
  • 5
    • 21344449731 scopus 로고    scopus 로고
    • Dendritic cells recognize tumor-specific glycosylation of carcinoembryonic antigen on colorectal cancer cells through dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin
    • van Gisbergen KP, Aamoudse CA, Meijer GA, et al. Dendritic cells recognize tumor-specific glycosylation of carcinoembryonic antigen on colorectal cancer cells through dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin. Cancer Res 2005; 65:5935-5944.
    • (2005) Cancer Res , vol.65 , pp. 5935-5944
    • van Gisbergen, K.P.1    Aamoudse, C.A.2    Meijer, G.A.3
  • 6
    • 33747362224 scopus 로고    scopus 로고
    • Dendritic cells matured with TNF can be further activated in vitro and after subcutaneous injection in vivo which converts their tolerogenicity into immunogenicity
    • Voigtlander C, Rossner S, Cierpka E, et al. Dendritic cells matured with TNF can be further activated in vitro and after subcutaneous injection in vivo which converts their tolerogenicity into immunogenicity. J Immunother 2006; 29:407-415.
    • (2006) J Immunother , vol.29 , pp. 407-415
    • Voigtlander, C.1    Rossner, S.2    Cierpka, E.3
  • 7
    • 30944463883 scopus 로고    scopus 로고
    • COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis
    • Muthian G, Raikwar HP, Johnson C, et al. COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis. J Clin Immunol 2006; 26:73-85.
    • (2006) J Clin Immunol , vol.26 , pp. 73-85
    • Muthian, G.1    Raikwar, H.P.2    Johnson, C.3
  • 8
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003; 3:133-146.
    • (2003) Nat Rev Immunol , vol.3 , pp. 133-146
    • Trinchieri, G.1
  • 9
    • 1542514719 scopus 로고    scopus 로고
    • Concomitant helper response rescues otherwise low avidity CD8+ memory CTLs to become efficient effectors in vivo
    • Kumaraguru U, Suvas S, Biswas PS, Azkur AK, Rouse BT. Concomitant helper response rescues otherwise low avidity CD8+ memory CTLs to become efficient effectors in vivo. J Immunol 2004; 172:3719-3724.
    • (2004) J Immunol , vol.172 , pp. 3719-3724
    • Kumaraguru, U.1    Suvas, S.2    Biswas, P.S.3    Azkur, A.K.4    Rouse, B.T.5
  • 10
    • 0041347751 scopus 로고    scopus 로고
    • In vitro induction of tumor-specific HLA class I-restricted CD8+ cytotoxic T lymphocytes from patients with locally advanced breast cancer by tumor antigen-pulsed autologous dendritic cells
    • Kass R, Agha J, Bellone S, et al. In vitro induction of tumor-specific HLA class I-restricted CD8+ cytotoxic T lymphocytes from patients with locally advanced breast cancer by tumor antigen-pulsed autologous dendritic cells. J Surg Res 2003; 112:189-197.
    • (2003) J Surg Res , vol.112 , pp. 189-197
    • Kass, R.1    Agha, J.2    Bellone, S.3
  • 11
    • 33645086129 scopus 로고    scopus 로고
    • Combinational adenovirus-mediated gene therapy and dendritic cell vaccine in combating well-established tumors
    • Xia D, Moyana T, Xiang J. Combinational adenovirus-mediated gene therapy and dendritic cell vaccine in combating well-established tumors. Cell Res 2006; 16:241-259
    • (2006) Cell Res , vol.16 , pp. 241-259
    • Xia, D.1    Moyana, T.2    Xiang, J.3
  • 12
    • 0141720783 scopus 로고    scopus 로고
    • Cancer vaccines: Between the idea and the reality
    • Finn OJ. Cancer vaccines: between the idea and the reality. Nature Rev Immunol 2003; 3:630-641.
    • (2003) Nature Rev Immunol , vol.3 , pp. 630-641
    • Finn, O.J.1
  • 13
    • 0036852191 scopus 로고    scopus 로고
    • Natural selection of tumor variants in the generation of 'tumor escape' phenotypes
    • Khong HT, Restifo NP. Natural selection of tumor variants in the generation of 'tumor escape' phenotypes. Nature Immunol 2002; 3:999-1005.
    • (2002) Nature Immunol , vol.3 , pp. 999-1005
    • Khong, H.T.1    Restifo, N.P.2
  • 14
    • 0043244867 scopus 로고    scopus 로고
    • Antigen-dependent proliferation CD4+CD25+ regulatory T cells in vivo
    • Walker LS, Chodos A, Eggena M, Dooms H, Abbas AK. Antigen-dependent proliferation CD4+CD25+ regulatory T cells in vivo. J Exp Med 2003; 198:249-258.
    • (2003) J Exp Med , vol.198 , pp. 249-258
    • Walker, L.S.1    Chodos, A.2    Eggena, M.3    Dooms, H.4    Abbas, A.K.5
  • 15
    • 0036314191 scopus 로고    scopus 로고
    • Complicated mechanisms of class II transactivator transcription deficiency in small cell lung cancer and neuroblastoma
    • Yazawa T, Ito T, Kamma H, et al. Complicated mechanisms of class II transactivator transcription deficiency in small cell lung cancer and neuroblastoma. Am J Pathol 2002; 161:291-300.
    • (2002) Am J Pathol , vol.161 , pp. 291-300
    • Yazawa, T.1    Ito, T.2    Kamma, H.3
  • 16
    • 0032938514 scopus 로고    scopus 로고
    • Lack of class II transactivator causes severe deficiency of HLA-DR expression in small cell lung cancer
    • Yazawa T, Kamma H, Fujiwara M, et al. Lack of class II transactivator causes severe deficiency of HLA-DR expression in small cell lung cancer. J Pathol 1999; 187:191-199.
    • (1999) J Pathol , vol.187 , pp. 191-199
    • Yazawa, T.1    Kamma, H.2    Fujiwara, M.3
  • 17
    • 0034669956 scopus 로고    scopus 로고
    • Th1 and Th2 cell clones to a poorly immunogenic tumor antigen initiate CD8+ T cell-dependent tumor eradication in vivo
    • Francesca Fallarino, Ursula Grohmann, Roberta Bianchi, et al. Th1 and Th2 cell clones to a poorly immunogenic tumor antigen initiate CD8+ T cell-dependent tumor eradication in vivo. J Immunol 2000; 165:5495-5501.
    • (2000) J Immunol , vol.165 , pp. 5495-5501
    • Fallarino, F.1    Grohmann, U.2    Bianchi, R.3
  • 18
    • 0032418812 scopus 로고    scopus 로고
    • The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses
    • Kalams SA, Walker BD. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J Exp Med 1998; 188:2199.
    • (1998) J Exp Med , vol.188 , pp. 2199
    • Kalams, S.A.1    Walker, B.D.2
  • 19
    • 0035881885 scopus 로고    scopus 로고
    • Spontaneous cytotoxic T cell responses against surviving-derived MHC class I-restricted T cell epitopes in situ as well as ex vivo in cancer patients
    • Andersen MH, Ostergaard Pedersen L, Capeller B, et al. Spontaneous cytotoxic T cell responses against surviving-derived MHC class I-restricted T cell epitopes in situ as well as ex vivo in cancer patients. Cancer Res 2001; 61:5964-5971.
    • (2001) Cancer Res , vol.61 , pp. 5964-5971
    • Andersen, M.H.1    Ostergaard Pedersen, L.2    Capeller, B.3
  • 20
    • 14544275527 scopus 로고    scopus 로고
    • Role of tumor cell immune escape mechanisms in cytomegalovirus-mediated oncomodulation
    • Cinatl JJ, Scholz M, Doerr HW. Role of tumor cell immune escape mechanisms in cytomegalovirus-mediated oncomodulation. Med Res Rev 2005; 25:167-185.
    • (2005) Med Res Rev , vol.25 , pp. 167-185
    • Cinatl, J.J.1    Scholz, M.2    Doerr, H.W.3
  • 21
    • 0034650421 scopus 로고    scopus 로고
    • Surman D, Dudley ME, Overwijk WW, Restifo NP. Cutting edge: CD4+ T cell control of CD8+ T cell reactivity to a model tumor antigen. J Immunol 2000; 164:562-565.
    • Surman D, Dudley ME, Overwijk WW, Restifo NP. Cutting edge: CD4+ T cell control of CD8+ T cell reactivity to a model tumor antigen. J Immunol 2000; 164:562-565.
  • 22
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Weiping Zou. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 2005; 5:263-274.
    • (2005) Nat Rev Cancer , vol.5 , pp. 263-274
    • Zou, W.1
  • 23
    • 0036852241 scopus 로고    scopus 로고
    • Cancer immunoediting: From immunosurveillance to tumor escape
    • Dunn GP, Bruce AT, et al. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 2002; 3:991-998.
    • (2002) Nat Immunol , vol.3 , pp. 991-998
    • Dunn, G.P.1    Bruce, A.T.2
  • 24
    • 0036888684 scopus 로고    scopus 로고
    • CD4+ regulatory T cells in autoimmunity and allergy
    • Maria A Curotto de Lafaille, Juan J Lafaille, et al. CD4+ regulatory T cells in autoimmunity and allergy. Curr Opin Immunol 2002; 14:771-778.
    • (2002) Curr Opin Immunol , vol.14 , pp. 771-778
    • Curotto de Lafaille, M.A.1    Lafaille, J.J.2
  • 25
    • 16844362608 scopus 로고    scopus 로고
    • Mechanisms of suppression by suppressor T cells
    • Harald von Boehmer. Mechanisms of suppression by suppressor T cells. Nat Immunol 2005; 6:338-344.
    • (2005) Nat Immunol , vol.6 , pp. 338-344
    • von Boehmer, H.1
  • 26
    • 4644342928 scopus 로고    scopus 로고
    • Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells
    • Turk MJ, Guevara-Patino JA, Rizzuto, et al. Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J Exp Med 2004; 200:771-782.
    • (2004) J Exp Med , vol.200 , pp. 771-782
    • Turk, M.J.1    Guevara-Patino, J.A.2    Rizzuto3
  • 27
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004; 10:942-949.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3
  • 28
    • 16844378685 scopus 로고    scopus 로고
    • Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma
    • Lars A Ormandy, Tina Hillemann, Heiner Wedemeyer, et al. Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res 2005; 65:2457-2464.
    • (2005) Cancer Res , vol.65 , pp. 2457-2464
    • Ormandy, L.A.1    Hillemann, T.2    Wedemeyer, H.3
  • 29
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and nonself
    • Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and nonself. Nat Immunol 2005; 6:345-352.
    • (2005) Nat Immunol , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 30
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996; 271:1734-1736.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 31
    • 0032544067 scopus 로고    scopus 로고
    • CTLA-4 blockade synergizes with tumor-derived granulocyte macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
    • Hurwitz AA, Yu TF, et al. CTLA-4 blockade synergizes with tumor-derived granulocyte macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma. Proc Natl Acad Sci USA 1998; 95:10067-10071.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10067-10071
    • Hurwitz, A.A.1    Yu, T.F.2
  • 32
    • 0033168037 scopus 로고    scopus 로고
    • Tumor Rejection by in vivo administration of anti-CD25 (interleukin-2 receptor a) monoclonal antibody
    • Shozaburo Onizuka, Isao Tawara, Jun Shimizu, et al. Tumor Rejection by in vivo administration of anti-CD25 (interleukin-2 receptor a) monoclonal antibody. Cancer Res 1999; 59:3128-3133.
    • (1999) Cancer Res , vol.59 , pp. 3128-3133
    • Onizuka, S.1    Tawara, I.2    Shimizu, J.3
  • 33
    • 0033571105 scopus 로고    scopus 로고
    • Induction of tumor immunity by removing CD25+CD4+ T cells: A common basis between tumor immunity and autoimmunity
    • Jun Shimizu, Sayuri Yamazaki, Shimon Sakaguchi. Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Immunol 1999; 163:5211-5218.
    • (1999) J Immunol , vol.163 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 34
    • 0035903324 scopus 로고    scopus 로고
    • Synergism of cytotoxic T lymphocyte associated antigen 4 blockade and depletion of CD25+ regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
    • Sutmuller RP, et al. Synergism of cytotoxic T lymphocyte associated antigen 4 blockade and depletion of CD25+ regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med 2001; 194:823-832.
    • (2001) J Exp Med , vol.194 , pp. 823-832
    • Sutmuller, R.P.1
  • 35
    • 33747482209 scopus 로고    scopus 로고
    • Immunization with autologous T cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45β
    • Li Wang, Fang Du, Qi Cao, et al. Immunization with autologous T cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45β. Cell Res 2006; 16:702-712.
    • (2006) Cell Res , vol.16 , pp. 702-712
    • Wang, L.1    Du, F.2    Cao, Q.3
  • 36
    • 22544450462 scopus 로고    scopus 로고
    • NF kappa B-inducing kinase deficiency results in the development of a subset of regulatory T cells, which shows a hyperproliferative activity upon glucocorticoid-induced TNF receptor family-related gene stimulation
    • Lu LF, Gondek DC, Scott ZA, Noelle RJ. NF kappa B-inducing kinase deficiency results in the development of a subset of regulatory T cells, which shows a hyperproliferative activity upon glucocorticoid-induced TNF receptor family-related gene stimulation. J Immunol 2005; 175:1651-1167.
    • (2005) J Immunol , vol.175 , pp. 1651-1167
    • Lu, L.F.1    Gondek, D.C.2    Scott, Z.A.3    Noelle, R.J.4
  • 37
    • 0037105416 scopus 로고    scopus 로고
    • Adoptive immunotherapy of advanced tumors with CD62 L-selectin(low) tumor-sensitized T lymphocytes following ex vivo hyperexpansion
    • Wang LX, Chen BG, Plautz GE. Adoptive immunotherapy of advanced tumors with CD62 L-selectin(low) tumor-sensitized T lymphocytes following ex vivo hyperexpansion. J Immunol 2002; 169:3314-3320.
    • (2002) J Immunol , vol.169 , pp. 3314-3320
    • Wang, L.X.1    Chen, B.G.2    Plautz, G.E.3
  • 38
    • 0037103132 scopus 로고    scopus 로고
    • Early events of TCR signaling are distinct in human Th1 and Th2 cells
    • Hannier S, Bitegye C, Demotz S. Early events of TCR signaling are distinct in human Th1 and Th2 cells. J Immunol 2002; 169:1904-1911.
    • (2002) J Immunol , vol.169 , pp. 1904-1911
    • Hannier, S.1    Bitegye, C.2    Demotz, S.3
  • 39
    • 0037124339 scopus 로고    scopus 로고
    • The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: Role of widely separated regulatory elements
    • Kim HP, Leonard WJ. The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements. EMBO J 2002 21:3051-3059.
    • (2002) EMBO J , vol.21 , pp. 3051-3059
    • Kim, H.P.1    Leonard, W.J.2
  • 40
    • 33748865133 scopus 로고    scopus 로고
    • TCR-independent cytokine stimulation induces non-MHC-restricted T cell activity and is negatively regulated by HLA class I
    • von Geldern M, Simm B, Braun M, et al. TCR-independent cytokine stimulation induces non-MHC-restricted T cell activity and is negatively regulated by HLA class I. Eur J Immunol 2006; 36:2347-2358.
    • (2006) Eur J Immunol , vol.36 , pp. 2347-2358
    • von Geldern, M.1    Simm, B.2    Braun, M.3
  • 41
    • 26844577145 scopus 로고    scopus 로고
    • Both regulatory T cells and antitumor effector T cells are primed in the same draining lymph nodes during tumor progression
    • Hiura T, Kagamu H, Miura S, et al. Both regulatory T cells and antitumor effector T cells are primed in the same draining lymph nodes during tumor progression. J Immunol 2005; 175:5058-5066.
    • (2005) J Immunol , vol.175 , pp. 5058-5066
    • Hiura, T.1    Kagamu, H.2    Miura, S.3
  • 42
    • 0034669969 scopus 로고    scopus 로고
    • Helper-independent, L-selectinlow CD8+ T cells with broad anti-tumor efficacy are naturally sensitized during tumor progression
    • Peng L, Kjaergaard J, Plautz GE, et al. Helper-independent, L-selectinlow CD8+ T cells with broad anti-tumor efficacy are naturally sensitized during tumor progression. J Immunol 2000; 165:5738-5749.
    • (2000) J Immunol , vol.165 , pp. 5738-5749
    • Peng, L.1    Kjaergaard, J.2    Plautz, G.E.3
  • 43
    • 29444449586 scopus 로고    scopus 로고
    • Differential mechanisms for T lymphocyte recruitment in normal and neoplastic human gastric mucosa
    • Enarsson K, Johnsson E, Lindholm C, et al. Differential mechanisms for T lymphocyte recruitment in normal and neoplastic human gastric mucosa. Clin Immunol 2006; 118:24-34.
    • (2006) Clin Immunol , vol.118 , pp. 24-34
    • Enarsson, K.1    Johnsson, E.2    Lindholm, C.3
  • 44
    • 33749123725 scopus 로고    scopus 로고
    • A role for inflammatory mediators in the induction of immunoregulatory B cells
    • Matsumura Y, Byrne SN, Nghiem DX, Miyahara Y, Ullrich SE. A role for inflammatory mediators in the induction of immunoregulatory B cells. J Immunol 2006; 177:4810-4817.
    • (2006) J Immunol , vol.177 , pp. 4810-4817
    • Matsumura, Y.1    Byrne, S.N.2    Nghiem, D.X.3    Miyahara, Y.4    Ullrich, S.E.5
  • 45
    • 33646896314 scopus 로고    scopus 로고
    • Activation of thymic T cells by MHC alloantigen requires syngeneic, activated CD4+ T cells and B cells as APC
    • Strutt TM, Uzonna J, McKinstry KK, Bretscher PA. Activation of thymic T cells by MHC alloantigen requires syngeneic, activated CD4+ T cells and B cells as APC. Int Immunol 2006; 18:719-728.
    • (2006) Int Immunol , vol.18 , pp. 719-728
    • Strutt, T.M.1    Uzonna, J.2    McKinstry, K.K.3    Bretscher, P.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.