Early events of TCR signaling are distinct in human Th1 and Th2 cells

Journal of Immunology

Volumn 169, Issue 4, 2002, Pages 1904-1911

  Hannier, Sigrid ^a   Bitegye, Christina ^a   Demotz, Stéphane ^a  

^a NONE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENOSOBENZENE; CD28 ANTIGEN; CD3 ANTIGEN; HLA DR1 ANTIGEN; INTERLEUKIN 2 RECEPTOR; PHOSPHATASE; PROTEIN; PROTEIN DR1; PROTEIN KINASE ZAP 70; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN PRESENTING CELL; ARTICLE; CELL LYSATE; CONTROLLED STUDY; CROSS LINKING; HUMAN; HUMAN CELL; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN IMMOBILIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

EID: 0037103132     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.4.1904     Document Type: Article

References (33)

1. Interactions of TCR tyrosine based activation motifs with tyrosine kinases
2. The amplification of TCR signaling by dynamic membrane microdomains
3. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
4. T-cell signaling: The importance of receptor clustering
5. T lymphocyte costimulation mediated by recognition of membrane microdomains
6. Lymphokine production by human T cells in disease states
7. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
8. Markers of Th1 and Th2 cells
9. Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): Differential expression and responsiveness in Th1 and Th2 cells
10. Selective expression of a novel surface molecule by human Th2 cells in vivo
11. Transcriptional regulation of Th1/Th2 polarization
12. Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon γ production in human T lymphocytes
13. + T cells
14. Evidence implicating utilization of different T cell receptor-associated signaling pathways by Th1 and Th2 clones
15. Early activation signal transduction pathways of Th1 and Th2 cell clones stimulated with anti-CD3: Roles of protein tyrosine kinases in the signal for IL-2 and IL-4 production
16. Protein tyrosine phosphorylation: A possible common signaling pathway in human Th1 and Th2 cell clones
17. Can interleukin-10 be used as a true immunoregulatory cytokine?
18. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
19. Processing of DR1-restricted determinants from the fusion protein of measles virus following two distinct pathways
20. The processing routes determined by negatively charged residues in DR1-restricted T cell determinants
21. DR αβ dimers released from complexes with invariant chain fail to stimulate alloreactive T cell clones
22. Membrane compartmentation is required for efficient T cell activation
23. Tuning of T cell clone size and activation threshold by control of CD25 expression through mitogen-activated protein kinase pathways
24. High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR
25. Identification of a dynamic intracellular reservoir of CD86 protein in peripheral blood monocytes that is not associated with the Golgi complex
26. Distinct patterns of membrane microdomain partitioning in Th1 and Th2 cells
27. Th1 and Th2 deviation of myelin-autoreactive T cells by altered peptide ligands is associated with reciprocal regulation of Lck, Fyn, and ZAP-70
28. Regulation of tyrosine phosphorylation in isolated T cell membrane by inhibition of protein tyrosine phosphatases
29. lck protein tyrosine kinase by phenylarsine oxide, a phosphotyrosine phosphatase inhibitor
30. lck-associated proteins in T cells
31. The next wave: Protein tyrosine phosphatases enter T cell antigen receptor signalling
32. Detection of CD45 mRNA in murine Th1 but not Th2 clones
33. Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis