Chronic brain cytochrome oxidase inhibition selectively alters hippocampal cholinergic innervation and impairs memory: Prevention by ladostigil

Experimental Neurology

Volumn 206, Issue 2, 2007, Pages 209-219

  Luques, L ^a   Shoham, S ^b   Weinstock, M ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HERZOG HOSPITAL   (Israel)

Author keywords

Alzheimer's disease; Cholinergic transmission; Cholinesterase monoamine oxidase inhibitor; Cytochrome oxidase; Episodic memory; Increased plasticity; Sodium azide; Spatial memory

Indexed keywords

CYTOCHROME C OXIDASE; LADOSTIGIL; MONOAMINE OXIDASE INHIBITOR; NEUROMODULIN; SODIUM CHLORIDE; SODIUM NITRATE; TRANSFERRIN RECEPTOR; VESICULAR ACETYLCHOLINE TRANSPORTER; WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLINERGIC NERVE CELL; CHOLINERGIC TRANSMISSION; CINGULATE GYRUS; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; DIAGONAL BAND OF BROCA; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; EPISODIC MEMORY; FUNCTION TEST; HIPPOCAMPUS; IMMUNOREACTIVITY; LONG TERM CARE; MALE; MEMORY DISORDER; NERVE CELL PLASTICITY; NEUROCHEMISTRY; NONHUMAN; OSMOTIC PUMP; PARASYMPATHETIC INNERVATION; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; REDUCTION; SPATIAL MEMORY; STATISTICAL SIGNIFICANCE; UPREGULATION; VARICOSIS;

ACETYLCHOLINE; ALZHEIMER DISEASE; ANIMALS; CHOLINERGIC FIBERS; CHOLINESTERASE INHIBITORS; ELECTRON TRANSPORT COMPLEX IV; ENZYME INHIBITORS; GAP-43 PROTEIN; HIPPOCAMPUS; INDANS; MALE; MAZE LEARNING; MEMORY DISORDERS; NEURONAL PLASTICITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFERRIN; SEPTAL NUCLEI; SODIUM AZIDE; TREATMENT OUTCOME; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS;

EID: 34547129331     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2007.04.007     Document Type: Article

References (31)

1. Bartolini L., Casamenti F., and Pepeu G. Aniracetam restores object recognition impaired by age, scopolamine, and nucleus basalis lesions. Pharmacol. Biochem. Behav. 53 (1996) 277-283
2. Bennett M.C., Diamond D.M., Stryker S.L., Parks J.K., and Parker Jr. W.D. Cytochrome oxidase inhibition: a novel animal model of Alzheimer's disease. J Geriatr Psychiatry Neurol. 5 (1992) 93-101
3. Bennett M.C., Mlady G.W., Kwon Y.H., and Rose G.M. Chronic in vivo sodium azide infusion induces selective and stable inhibition of cytochrome c oxidase. J. Neurochem. 66 (1996) 2606-2611
4. Benowitz L.I., Rodriguez W.R., and Neve R.L. The pattern of GAP-43 immunostaining changes in the rat hippocampal formation during reactive synaptogenesis. Brain Res. Mol. Brain Res. 8 (1990) 17-23
5. Cada A., Gonzalez-Lima F., Rose G.M., and Bennett M.C. Regional brain effects of sodium azide treatment on cytochrome oxidase activity: a quantitative histochemical study. Metab. Brain Dis. 10 (1995) 303-320
6. Casademont J., Miro O., Rodriguez-Santiago B., Viedma P., Blesa R., and Cardellach F. Cholinesterase inhibitor rivastigmine enhance the mitochondrial electron transport chain in lymphocytes of patients with Alzheimer's disease. J. Neurol. Sci. 206 (2003) 23-26
7. Cooper J.D., and Sofroniew M.V. Increased vulnerability of septal cholinergic neurons to partial loss of target neurons in aged rats. Neuroscience 75 (1996) 29-35
8. Cotman C.W., and Anderson K.J. Synaptic plasticity and functional stabilization in the hippocampal formation: possible role in Alzheimer's disease. Adv. Neurol. 47 (1988) 313-335
9. Dougherty K.D., and Milner T.A. Cholinergic septal afferent terminals preferentially contact neuropeptide Y-containing interneurons compared to parvalbumin-containing interneurons in the rat dentate gyrus. J. Neurosci. 19 (1999) 10140-10152
10. Ellman G.L., Courtney K.D., Andres Jr. V., and Feather-Stone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7 (1961) 88-95
11. Ennaceur A., Neave N., and Aggleton J.P. Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix. Exp. Brain Res. 113 (1997) 509-519
12. Everitt B.J., and Robbins T.W. Central cholinergic systems and cognition. Annu. Rev. Psychol. 48 (1997) 649-684
13. Geddes J.W., Monaghan D.T., Cotman C.W., Lott I.T., Kim R.C., and Chui H.C. Plasticity of hippocampal circuitry in Alzheimer's disease. Science 230 (1985) 1179-1181
14. Goekoop R., Rombouts S.A., Jonker C., Hibbel A., Knol D.L., Truyen L., Barkhof F., and Scheltens P. Challenging the cholinergic system in mild cognitive impairment: a pharmacological fMRI study. Neuroimage 23 (2004) 1450-1459
15. Hardman R., Evans D.J., Fellows L., Hayes B., Rupniak H.T., Barnes J.C., and Higgins G.A. Evidence for recovery of spatial learning following entorhinal cortex lesions in mice. Brain Res. 758 (1997) 187-200
16. Hevner R.F., Liu S., and Wong-Riley M.T. An optimized method for determining cytochrome oxidase activity in brain tissue homogenates. J. Neurosci. Methods 50 (1993) 309-319
17. Hirai K., Aliev G., Nunomura A., Fujioka H., Russell R.L., Atwood C.S., Johnson A.B., Kress Y., Vinters H.V., Tabaton M., Shimohama S., Cash A.D., Siedlak S.L., Harris P.L., Jones P.K., Petersen R.B., Perry G., and Smith M.A. Mitochondrial abnormalities in Alzheimer's disease. J. Neurosci. 21 (2001) 3017-3023
18. Morris C.M., Candy J.M., Bloxham C.A., and Edwardson J.A. Distribution of transferrin receptors in relation to cytochrome oxidase activity in the human spinal cord, lower brainstem and cerebellum. J. Neurol. Sci. 111 (1992) 158-172
19. Mumby D.G., Gaskin S., Glenn M.J., Schramek T.E., and Lehmann H. Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts. Learn. Mem. 9 (2002) 49-57
20. Mutisya E.M., Bowling A.C., and Beal M.F. Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. J. Neurochem. 63 (1994) 2179-2184
21. Rekart J.L., Quinn B., Mesulam M.M., and Routtenberg A. Subfield-specific increase in brain growth protein in postmortem hippocampus of Alzheimer's patients. Neuroscience 126 (2004) 579-584
22. Shoham S., Bejar C., Kovalev E., and Weinstock M. Intracerebroventricular injection of streptozotocin causes neurotoxicity to myelin that contributes to spatial memory deficits in rats. Exp. Neurol. 184 (2003) 1043-1052
23. Smith D.E., Rapp P.R., McKay H.M., Roberts J.A., and Tuszynski M.H. Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons. J. Neurosci. 24 (2004) 4373-4381
24. Szabados T., Dul C., Majtenyi K., Hargitai J., Penzes Z., and Urbanics R. A chronic Alzheimer's model evoked by mitochondrial poison sodium azide for pharmacological investigations. Behav. Brain Res. 154 (2004) 31-40
25. Tanaka K., Ogawa N., Asanuma M., Kondo Y., and Mori A. Chronic administration of acetylcholinesterase inhibitor in the senescent rat brain. Neurobiol. Aging 15 (1994) 721-725
26. Valla J., Berndt J.D., and Gonzalez-Lima F. Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration. J. Neurosci. 21 (2001) 4923-4930
27. Van Groen T., and Wyss J.M. Connections of the retrosplenial granular b cortex in the rat. J. Comp. Neurol. 463 (2003) 249-263
28. Wang R.H., Bejar C., and Weinstock M. Gender differences in the effect of rivastigmine on brain cholinesterase activity and cognitive function in rats. Neuropharmacology 39 (2000) 497-506
29. Weinstock M., Gorodetsky E., Poltyrev T., Gross A., Sagi Y., and Youdim M. A novel cholinesterase and brain-selective monoamine oxidase inhibitor for the treatment of dementia comorbid with depression and Parkinson's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 27 (2003) 555-561
30. Winters B.D., Robbins T.W., and Everitt B.J. Selective cholinergic denervation of the cingulate cortex impairs the acquisition and performance of a conditional visual discrimination in rats. Eur J. Neurosci. 19 (2004) 490-496
31. Wong-Riley M. Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. Brain Res. 171 (1979) 11-28