Type I collagen mutation alters the strength and fatigue behavior of Mov13 cortical tissue

Journal of Biomechanics

Volumn 30, Issue 11-12, 1997, Pages 1141-1147

  Jepsen, Karl J ^a   Schaffler, Mitchell B ^b   Kuhn, Janet L ^c   Goulet, Robert W ^c   Bonadio, Jeffrey ^d   Goldstein, Steven A ^c,e  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HENRY FORD HOSPITAL   (United States)

^c Orthopaedic Research Laboratories   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Cortical bone; Damage; Osteogenesis imperfecta; Skeletal fragility; Transgenic model

Indexed keywords

BENDING STRENGTH; BRITTLENESS; COLLAGEN; MUTAGENESIS; PHYSIOLOGICAL MODELS; TISSUE;

MOV13 CORTICAL TISSUE; OSTEOGENESIS IMPERFECTA; SKELETAL FRAGILITY; TRANSGENIC MODEL; TYPE I COLLAGEN MUTATION;

BIOMECHANICS;

COLLAGEN TYPE 1;

ANIMAL TISSUE; ARTICLE; BONE MINERAL; BONE STRENGTH; BONE STRESS; CORTICAL BONE; FEMUR; GENE MUTATION; HYPOTHESIS; LONG BONE; MALE; MOUSE; NONHUMAN; OSTEOGENESIS IMPERFECTA; PRIORITY JOURNAL; TRANSGENIC ANIMAL;

ANALYSIS OF VARIANCE; ANIMALS; BONE AND BONES; BONE MATRIX; COLLAGEN; DENSITOMETRY, X-RAY; DISEASE MODELS, ANIMAL; ELASTICITY; FEMUR; FRACTURES, BONE; HETEROZYGOTE; MALE; MICE; MICE, TRANSGENIC; MINERALS; MUTATION; OSTEOGENESIS IMPERFECTA; POROSITY; STRESS, MECHANICAL;

EID: 0031278819     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9290(97)00088-2     Document Type: Article

References (26)

1. Ascenzi, A. and Bonucci, E. (1967) The tensile properties of single osteons. Anatomical Record 158, 375-386.
2. Ascenzi, A. and Bonucci, E. (1976) Mechanical similarities between alternate osteons and cross-ply laminates. Journal of Biomechanics 9, 65-71.
3. Bonadio, J., Jepsen, K. J., Mansoura, M. K., Jaenisch, R., Kuhn, J. L. and Goldstein, S. A. (1993) A murine skeletal adaptation that significantly increases cortical bone mechanical properties-implications for human skeletal fragility. Journal of Clinical Investigations 92, 1697-1705.
4. Bonadio, J., Saunders, T. L., Tsai, E., Goldstein, S. A., Morris-Wiman, J., Brinkley, L., Dolan, D. F., Altschular, R. A., Hawkins Jr, J. E., Bateman, J. F., Mascara, T. and Jaenisch, R. (1990) Transgenic mouse model of the mild dominant form of osteogenesis imperfecta. Proceedings of the National Academy of Sciences USA 87, 7145-7149.
5. Burstein, A. H., Currey, J. D., Frankel, V. H. and Reilly, D. T. (1972) The ultimate properties of bone tissue: The effects of yielding. Journal of Biomechanics 5, 35-44.
6. Byers, P. H. (1990) Brittle bones-fragile molecules: disorders of the collagen gene structure and expression. Trends in Genetics 6, 293-300.
7. Caler, W. E. and Carter, D. R. (1989) Bone creep-fatigue damage accumulation. Journal of Biomechanics 22, 625-635.
8. Carter, D. R. and Caler, W. E. (1983) Cycle-dependent and time-dependent bone fracture with repeated loading. Journal of Biomechanical Engineering 105, 166-170.
9. Carter, D. R. and Hayes, W. C. (1977) Compact bone fatigue damage - I. Residual strength and stiffness. Journal of Biomechanics 10, 325-337.
10. Carter, D. R. and Hayes, W. C. (1981) Uniaxial fatigue of human cortical bone. The influence of tissue physical characteristics. Journal of Biomechanics 14, 461-470.
11. Cassella, J. P., Andrews. K. and Ali, S. Y. (1992) Microanalytical studies of bone mineral in osteogensis imperfecta. Bone 13(1), 101-102.
12. Choi, K.. and Goldstein, S. A. (1992) A comparison of the fatigue behavior of human trabecular and cortical bone tissue. Journal of Biomechanics 25, 1371-1381.
13. Choi, K., Kuhn, J. L., Ciarelli, M. J. and Goldstein, S. A. (1990) The elastic moduli of human subchondral, trabecular, and cortical bone tissue and the size-dependency of cortical bone modulus. Journal of Biomechanics 23, 1103-1113.
14. Currey, J. D. and Brear, K. (1992) Fractal analysis of compact bone and antler fracture surfaces. Biomimetics 1(2), 103-118.
15. Hahn, H. T. and Kim, R. Y. (1976) Fatigue behavior of composite laminate. Journal of Composite Materials 10, 156-180.
16. Jepsen, K. J. (1994) Characterization of the hierarchical composite properties of cortical bone: a transgenic approach. Ph.D. thesis, The University of Michigan, Ann Arbor, MI.
17. Jepsen, K. J., Golstein, S. A., Kuhn, J. L., Schaffler, M. B. and Bonadio, J. (1996) Type I collagen mutation compromises the post-yield behavior of Mov 13 long bone. Journal of Orthopaedics Research 14, 493-499.
18. Kuhn, J. L., Goldstein, S. A., Choi, K., London, M., Feldkamp, L. A. and Matthew, L. S. (1989) A comparison of the trabecular and cortical tissue moduli from human iliac crests. Journal of Orthopaedics Research 7, 876-884.
19. Landis, W. J. ( 1995) The strength of a calcified tissue depends in part on the molecular structure and organization of its constituent mineral crystals in their organic matrix. Bone 16(5), 533-544.
20. Nagami, H. and Oohira, A. (1988) Defective association between collagen fibrils and proteoglycans in fragile bone of osteogenesis imperfecta. Clinical Orthopaedics 232, 284-291.
21. Piekarski, K. (1970) Fracture of bone. Journal of Applied Physics 41(1), 215-223.
22. Reifsnider, K. L. (1991) Damage and damage mechanics. In Fatigue of Composite Materials, ed. K. L. Reifsnider, pp. 11 -77. Elsevier, New York.
23. Schaffler, M. B., Radin, E. L. and Burr, D. B. (1990) Long-term fatigue behavior of compact bone at low strain magnitude and rate. Bone 11, 321-326.
24. Schnieke, A., Harbers, K. and Jaenisch, R. (1983) Embryonic lethal mutation in mice induced by retrovirus insertion into the α 1(1) collagen gene. Nature 304, 315-320.
25. Teitelbaum, S. L., Kraft, W. J., Lang, R. and Avioli, L. V. (1974) Bone collagen aggregation abnormalities in osteogenesis imperfecta. Calcification of Tissue Research 17, 75-79.
26. Zioupos, P., Currey, J. D. and Sedman, A. J. (1994) An examination of the micromechanics of failure of bone and antler by acoustic emission tests and Laser Scanning Confocal microscopy. Medical Engineering and Physics 16, 203-212.