Interleukin-10 regulates transforming growth factor-β signaling in cultured human bronchial epithelial cells

Respiration

Volumn 74, Issue 4, 2007, Pages 454-459

  Fueki, Naoto ^a,b   Sagara, Hironori ^a   Akimoto, Kazumi ^a   Ota, Mayumi ^a   Okada, Takenori ^a   Sugiyama, Kumiya ^a   Fueki, Makoto ^a,b   Makino, Sohei ^b   Fukuda, Takeshi ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b Jobu Hospital for Respiratory Disease   (Japan)

Author keywords

Bronchial asthma; IL 10; Smad7; TGF signaling

Indexed keywords

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 5; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BRONCHUS; BRONCHUS MUCOSA; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

BRONCHI; CELL LINE; EARLY GROWTH RESPONSE TRANSCRIPTION FACTORS; EPITHELIAL CELLS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; HUMANS; INTERLEUKIN-10; INTERLEUKIN-5; KRUPPEL-LIKE TRANSCRIPTION FACTORS; RECEPTORS, INTERLEUKIN-10; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; ZINC FINGERS;

EID: 34447649183     PISSN: 00257931     EISSN: None     Source Type: Journal    
DOI: 10.1159/000101057     Document Type: Article

References (29)

1. Makino S, Ohta K, Nishima S, Morikawa A: Asthma Prevention and Management Guidelines 200, Japan. Int Arch Allergy Immunol 2005;136:(suppl 1):1-50.
2. National Heart, Lung, and Blood Institute: Global Strategy for Asthma Management and Prevention, revised 2002. Bethesda, US Department of Health and Human Services; 2002, NIH Pub No. 02-3659.
3. Holgate ST: Unmet clinical needs in asthma. Clin Exp Allergy 2000;30(suppl 1):1.
4. Bousquet J, Jeffery PK, Busse WW, et al: Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000;161:1720-1745.
5. Vignola AM, Kips J, Bousquet J: Tissue remodeling as a feature of persistent asthma. J Allergy Clin Immunol 2000;105:1041-1053.
6. Ohno I, Nitta Y, Yamauchi K, et al: Eosinophils as a potential source of platelet-derived growth factor B-chain (PDGF-B) in nasal polyposis and bronchial asthma. Am J Respir Cell Mol Biol 1995;13:639-647.
7. Boulay ME, Prince P, Deschesnes F, et al: Metalloproteinase-9 in induced sputum correlates with the severity of the late allergen-induced asthmatic response. Respiration 2004;71:216-224.
8. Chen XQ, Yang J, Hu SP, et al: Increased expression of CD86 and reduced production of IL-12 and IL-10 by monocyte-derived dendritic cells from allergic asthmatics and their effects on Th1-and Th2-type cytokine balance. Respiration 2006;73:34-40.
9. Massague J: TGF-β signal transduction. Annu Rev Biochem 1998;67:753-791.
10. Nakao A, Imamura T, Souchenlnytskyi S, et al: TGF-β receptor-mediated signaling through Smad2, Smad3 and Smad4. EMBO J 1997;16:5353-5362.
11. Heldin CH, Miyazono K, ten Dijke P: TGF-β signaling from cell membrane to nucleus through Smad proteins. Nature 1997;390:465-471.
12. Nakao A, Afrankhte M, Moren A, et al: Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature 1997;389:631-635
13. Nakao A, Fuji M, Matsumura R, et al: Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest 1999;104:5-11.
14. Sagara H, Okada T, Okumura K, et al: Activation of TGF-β/Smad2 signaling is associated with airway remodeling in asthma. J Allergy Clin Immunol 2002;110:249-254.
15. Jackson AL, Warner NL: Preparation, staining and analysis by flow cytometry of peripheral blood leukocytes; in Rose NR, Friedman M, Fahey HL (eds): Manual of Clinical Laboratory Immunology, ed 3. Washington, American Society for Microbiology, 1986, pp 226-235.
16. Chomczynski P: A reagent for the single-step simultaneous isolation of RNA, DNA, and protein from cell and tissue samples. Biotechniques 1993;15:532-536.
17. Ohno I, Nitta Y, Yamauchi K, et al: Transforming growth factor-β1 gene expression by eosinophils in asthmatic airway inflammation. Am J Respir Cell Mol Biol 1996;15:404-409.
18. Minshall EM, Leung DY, Martin RJ, et al: Eosinophil-associated TGF-β1 mRNA expression and airways fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 1997;17:326-333.
19. Vignola A, Chanez P, Chiappara G, et al: Transforming growth factor-β expression in mucosa biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 1997;156:591-599.
20. Massague J: How cells read TGF-β signals. Nat Rev Mol Cell Biol 2000;1:169-178.
21. Moustakas A, Souchelnyskyi S, Heldin CH: Smad regulation in TGF-β signal transduction. J Cell Sci 2001;14:4359-4369.
22. Nakao A, Sagara H, Setoguchi Y, et al: Expression of Smad7 in bronchial epithelial cells is inversely correlated to basement membrane thickness and airway hyperresponsiveness in asthma. J Allergy Clin Immunol 2002;110:873-878.
23. Johnsen SA, Subramaniam M, Katagiri T, et al: Transcriptional regulation of Smad2 is required for enhancement of TGFβ/Smad signaling by TGFβ inducible early gene. J Cell Biochem 2002;87:233-241.
24. Prete GD, Carli MD, Almerigogna F, et al: Human IL-10 is produced by both type1 helper (Th1) and type2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol 1993;150:353-360.
25. Zuany-Amorim C, Haile S, Leduc D, et al: Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice. J Clin Invest 1995;95:2644-2651.
26. Grung G, Corry DB, Leach MW, et al: Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J Exp Med 1997;185:1089-1099.
27. Groux H, Bigler M, de Vries JE, et al: Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+T cells. J Exp Med 1996;184:19-29.
28. D'Andrea A, Aste-Amezaga M, Valiante NM, et al: Interleukin-10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993;178:1041-1048.
29. Borish L, Aarons A, Rumbyrt J, et al: Interleukin-10 regulation in normal subjects and patients with asthma. J Allergy Clin Immunol 996;97:1288-1296.