[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

Biochemical Pharmacology

Volumn 74, Issue 5, 2007, Pages 780-786

  Na, Yong Joo ^a   Baek, Heung Su ^a   Ahn, Soo Mi ^a   Shin, Hyun Jung ^a   Chang, Ih Seop ^a   Hwang, Jae Sung ^a  

^a AmorePacific Corporation   (South Korea)

Author keywords

c kit; Depigmentation; Skin

Indexed keywords

[4 T BUTYLPHENYL] N (4 IMIDAZOL 1 YL PHENYL)SULFONAMIDE; ISCK 03; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SCATTER FACTOR; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DEPIGMENTATION; DRUG EFFECT; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; GUINEA PIG; HUMAN; HUMAN CELL; HYPERPIGMENTATION; MAJOR CLINICAL STUDY; MELANOGENESIS; MELANOMA CELL; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION; GUINEA PIGS; HUMANS; HYPERPIGMENTATION; IMIDAZOLES; MELANINS; MELANOMA; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-KIT; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 34447626117     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.05.028     Document Type: Article

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