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Volumn 47, Issue 8, 2007, Pages 1035-1042

Analysis of factors influencing tacrolimus levels and immunoassay bias in renal transplantation

Author keywords

Renal transplantation; Tacrolimus; Therapeutic drug monitoring

Indexed keywords

CIPROFLOXACIN; CLARITHROMYCIN; CORTICOSTEROID; FLUCONAZOLE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; STEROID; TACROLIMUS;

EID: 34447621005     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270007303765     Document Type: Article
Times cited : (8)

References (49)
  • 1
    • 26644469263 scopus 로고    scopus 로고
    • Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: Meta-analysis and meta-regression of randomised trial data
    • Webster AC, Woodroffe RC, Taylor RS, et al. Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data. BMJ. 2005 ; 331: 810.
    • (2005) BMJ. , vol.331 , pp. 810
    • Webster, A.C.1    Woodroffe, R.C.2    Taylor, R.S.3
  • 2
    • 0032855982 scopus 로고    scopus 로고
    • Tacrolimus whole blood concentrations correlate closely to side-effects in renal transplant recipients
    • Bottiger Y., Brattstrom C., Tyden G., et al. Tacrolimus whole blood concentrations correlate closely to side-effects in renal transplant recipients. Br J Clin Pharmacol. 1999 ; 48: 445-448.
    • (1999) Br J Clin Pharmacol. , vol.48 , pp. 445-448
    • Bottiger, Y.1    Brattstrom, C.2    Tyden, G.3
  • 3
    • 0029849460 scopus 로고    scopus 로고
    • Relationship of FK506 whole blood concentrations and efficacy and toxicity after liver and kidney transplantation
    • Kershner RP, Fitzsimmons WE Relationship of FK506 whole blood concentrations and efficacy and toxicity after liver and kidney transplantation. Transplantation. 1996 ; 62: 920-926.
    • (1996) Transplantation , vol.62 , pp. 920-926
    • Kershner, R.P.1    Fitzsimmons, W.E.2
  • 4
    • 0029805879 scopus 로고    scopus 로고
    • An open-label, concentration-ranging trial of FK506 in primary kidney transplantation: A report of the United States Multicenter FK506 Kidney Transplant Group
    • Laskow DA, Vincenti F., Neylan JF, et al. An open-label, concentration-ranging trial of FK506 in primary kidney transplantation: a report of the United States Multicenter FK506 Kidney Transplant Group. Transplantation. 1996 ; 62: 900-905.
    • (1996) Transplantation , vol.62 , pp. 900-905
    • Laskow, D.A.1    Vincenti, F.2    Neylan, J.F.3
  • 5
    • 0034852733 scopus 로고
    • Low tacrolimus concentrations and increased risk of early acute rejection in adult renal transplantation
    • Staatz C., Taylor P., Tett S. Low tacrolimus concentrations and increased risk of early acute rejection in adult renal transplantation. Nephrol Dial Transplant. 2001 ; 16: 1905 -1909.
    • (1909) Nephrol Dial Transplant. , vol.16 , pp. 1905
    • Staatz, C.1    Taylor, P.2    Tett, S.3
  • 6
    • 2042515610 scopus 로고    scopus 로고
    • Clinical efficacy and toxicity profile of tacrolimus and mycophenolic acid in relation to combined long-term pharmacokinetics in de novo renal allograft recipients
    • Kuypers DR, Claes K., Evenepoel P., et al. Clinical efficacy and toxicity profile of tacrolimus and mycophenolic acid in relation to combined long-term pharmacokinetics in de novo renal allograft recipients. Clin Pharmacol Ther. 2004 ; 75: 434-447.
    • (2004) Clin Pharmacol Ther. , vol.75 , pp. 434-447
    • Kuypers, D.R.1    Claes, K.2    Evenepoel, P.3
  • 7
    • 0034961129 scopus 로고    scopus 로고
    • Pharmacokinetic basis for the efficient and safe use of low-dose mycophenolate mofetil in combination with tacrolimus in kidney transplantation
    • Mourad M., Malaise J., Chaib Eddour D, et al. Pharmacokinetic basis for the efficient and safe use of low-dose mycophenolate mofetil in combination with tacrolimus in kidney transplantation. Clin Chem. 2001 ; 47: 1241-1248.
    • (2001) Clin Chem. , vol.47 , pp. 1241-1248
    • Mourad, M.1    Malaise, J.2    Chaib Eddour, D.3
  • 8
    • 0032986187 scopus 로고    scopus 로고
    • Low systemic exposure to tacrolimus correlates with acute rejection
    • Undre NA, van Hooff J., Christiaans M., et al. Low systemic exposure to tacrolimus correlates with acute rejection. Transplant Proc. 1999 ; 31: 296-298.
    • (1999) Transplant Proc. , vol.31 , pp. 296-298
    • Undre, N.A.1    Van Hooff, J.2    Christiaans, M.3
  • 9
    • 0028810418 scopus 로고
    • Consensus document: Therapeutic monitoring of tacrolimus (FK-506)
    • Jusko WJ, Thomson AW, Fung J., et al. Consensus document: therapeutic monitoring of tacrolimus (FK-506). Ther Drug Monit. 1995 ; 17: 606-614.
    • (1995) Ther Drug Monit. , vol.17 , pp. 606-614
    • Jusko, W.J.1    Thomson, A.W.2    Fung, J.3
  • 10
    • 0032420378 scopus 로고    scopus 로고
    • Tacrolimus metabolite cross-reactivity in different tacrolimus assays
    • Murthy JN, Davis DL, Yatscoff RW, et al. Tacrolimus metabolite cross-reactivity in different tacrolimus assays. Clin Biochem. 1998 ; 31: 613-617.
    • (1998) Clin Biochem. , vol.31 , pp. 613-617
    • Murthy, J.N.1    Davis, D.L.2    Yatscoff, R.W.3
  • 11
    • 0036689906 scopus 로고    scopus 로고
    • False positive blood tacrolimus concentration in microparticle enzyme immunoassay
    • Homma M., Tomita T., Yuzawa K., et al. False positive blood tacrolimus concentration in microparticle enzyme immunoassay. Biol Pharm Bull. 2002 ; 25: 1119-1120.
    • (2002) Biol Pharm Bull , vol.25 , pp. 1119-1120
    • Homma, M.1    Tomita, T.2    Yuzawa, K.3
  • 12
    • 21044432822 scopus 로고    scopus 로고
    • Effects of some hematological parameters on whole blood tacrolimus concentration measured by two immunoassay-based analytical methods
    • Akbas SH, Ozdem S., Caglar S., et al. Effects of some hematological parameters on whole blood tacrolimus concentration measured by two immunoassay-based analytical methods. Clin Biochem. 2005 ; 38: 552-557.
    • (2005) Clin Biochem. , vol.38 , pp. 552-557
    • Sh, A.1    Ozdem, S.2    Caglar, S.3
  • 13
    • 19944430748 scopus 로고    scopus 로고
    • Effects of hematocrit value on microparticle enzyme immunoassay of tacrolimus concentration in therapeutic drug monitoring
    • Tomita T., Homma M., Yuzawa K., et al. Effects of hematocrit value on microparticle enzyme immunoassay of tacrolimus concentration in therapeutic drug monitoring. Ther Drug Monit. 2005 ; 27: 94-97.
    • (2005) Ther Drug Monit. , vol.27 , pp. 94-97
    • Tomita, T.1    Homma, M.2    Yuzawa, K.3
  • 14
    • 14544287267 scopus 로고    scopus 로고
    • Low hematocrit and serum albumin concentrations underlie the overestimation of tacrolimus concentrations by microparticle enzyme immunoassay versus liquid chromatography-tandem mass spectrometry
    • Brown NW, Gonde CE, Adams JE, Tredger JM Low hematocrit and serum albumin concentrations underlie the overestimation of tacrolimus concentrations by microparticle enzyme immunoassay versus liquid chromatography-tandem mass spectrometry. Clin Chem. 2005 ; 51: 586-592.
    • (2005) Clin Chem. , vol.51 , pp. 586-592
    • Brown, N.W.1    Gonde, C.E.2    Adams, J.E.3    Tredger, J.M.4
  • 15
    • 34447650998 scopus 로고    scopus 로고
    • Measurement of tacrolimus. does the choice of anticoagulant matter [abstract]
    • Michalska C., Shiferaw E., Johnston A., Holt D. Measurement of tacrolimus. does the choice of anticoagulant matter [abstract]. Ther Drug Monit. 2005 ; 27: 222.
    • (2005) Ther Drug Monit. , vol.27 , pp. 222
    • Michalska, C.1    Shiferaw, E.2    Johnston, A.3    Holt, D.4
  • 16
    • 33748187631 scopus 로고    scopus 로고
    • Clinical outcomes of renal transplantation using liquid chromatographic monitoring of tacrolimus
    • Borrows R., Chusney G., Loucaidou M., et al. Clinical outcomes of renal transplantation using liquid chromatographic monitoring of tacrolimus. Ther Drug Monit. 2006 ; 28: 269-273.
    • (2006) Ther Drug Monit. , vol.28 , pp. 269-273
    • Borrows, R.1    Chusney, G.2    Loucaidou, M.3
  • 17
    • 0036913473 scopus 로고    scopus 로고
    • Population pharmacokinetics of tacrolimus in adult kidney transplant recipients
    • Staatz CE, Willis C., Taylor PJ, Tett SE Population pharmacokinetics of tacrolimus in adult kidney transplant recipients. Clin Pharmacol Ther. 2002 ; 72: 660-669.
    • (2002) Clin Pharmacol Ther. , vol.72 , pp. 660-669
    • Staatz, C.E.1    Willis, C.2    Taylor, P.J.3    Tett, S.E.4
  • 18
    • 3242772986 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplantation
    • Staatz CE, Tett SE Clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplantation. Clin Pharmacokinet. 2004 ; 43: 623-653.
    • (2004) Clin Pharmacokinet. , vol.43 , pp. 623-653
    • Staatz, C.E.1    Tett, S.E.2
  • 19
    • 4344561078 scopus 로고    scopus 로고
    • Time-related clinical determinants of long-term tacrolimus pharmacokinetics in combination therapy with mycophenolic acid and corticosteroids: A prospective study in one hundred de novo renal transplant recipients
    • Kuypers Drj, Claes K., Evenepoel P., et al. Time-related clinical determinants of long-term tacrolimus pharmacokinetics in combination therapy with mycophenolic acid and corticosteroids: a prospective study in one hundred de novo renal transplant recipients. Clin Pharmacokinet. 2004 ; 43: 741-762.
    • (2004) Clin Pharmacokinet. , vol.43 , pp. 741-762
    • Drj, K.1    Claes, K.2    Evenepoel, P.3
  • 20
    • 0242558148 scopus 로고    scopus 로고
    • Increase in tacrolimus trough levels after steroid withdrawal
    • van Duijnhoven EM, Boots JM, Christiaans MH, et al. Increase in tacrolimus trough levels after steroid withdrawal. Transpl Int. 2003 ; 16: 721-725.
    • (2003) Transpl Int. , vol.16 , pp. 721-725
    • Van Duijnhoven, E.M.1    Boots, J.M.2    Christiaans, M.H.3
  • 21
    • 21844474002 scopus 로고    scopus 로고
    • Different evolution of trough and dose levels during the first year after transplantation for tacrolimus versus cyclosporine
    • Lemahieu WP, Maes BD, Vanrenterghem Y. Different evolution of trough and dose levels during the first year after transplantation for tacrolimus versus cyclosporine. Transplant Proc. 2005 ; 37: 2051-2053.
    • (2005) Transplant Proc. , vol.37 , pp. 2051-2053
    • Lemahieu, W.P.1    Maes, B.D.2    Vanrenterghem, Y.3
  • 22
    • 0036727094 scopus 로고    scopus 로고
    • Evaluation of a rapid micro-scale assay for tacrolimus by liquid chromatography-tandem mass spectrometry
    • Keevil BG, McCann SJ, Cooper DP, Morris MR Evaluation of a rapid micro-scale assay for tacrolimus by liquid chromatography-tandem mass spectrometry. Ann Clin Biochem. 2002 ; 39: 487-492.
    • (2002) Ann Clin Biochem. , vol.39 , pp. 487-492
    • Keevil, B.G.1    McCann, S.J.2    Cooper, D.P.3    Morris, M.R.4
  • 23
    • 0016916438 scopus 로고
    • Prediction of creatinine clearance from serum creatinine
    • Cockcroft DW, Gault MH Prediction of creatinine clearance from serum creatinine. Nephron. 1976 ; 16: 31-41.
    • (1976) Nephron. , vol.16 , pp. 31-41
    • Cockcroft, D.W.1    Gault, M.H.2
  • 24
    • 0021869646 scopus 로고
    • Course of acute renal failure studied by a model of creatinine kinetics
    • Moran SM, Myers BD Course of acute renal failure studied by a model of creatinine kinetics. Kidney Int. 1985 ; 27: 928-937.
    • (1985) Kidney Int. , vol.27 , pp. 928-937
    • Moran, S.M.1    Myers, B.D.2
  • 25
    • 0037443995 scopus 로고    scopus 로고
    • Erosive enterocolitis in mycophenolate mofetil-treated renal-transplant recipients with persistent afebrile diarrhea
    • Maes BD, Dalle I., Geboes K., et al. Erosive enterocolitis in mycophenolate mofetil-treated renal-transplant recipients with persistent afebrile diarrhea. Transplantation. 2003 ; 75: 665-672.
    • (2003) Transplantation , vol.75 , pp. 665-672
    • Maes, B.D.1    Dalle, I.2    Geboes, K.3
  • 26
    • 0036360906 scopus 로고    scopus 로고
    • Drug interactions with tacrolimus
    • van Gelder T. Drug interactions with tacrolimus. Drug Saf. 2002 ; 25: 707-712.
    • (2002) Drug Saf. , vol.25 , pp. 707-712
    • Van Gelder, T.1
  • 27
    • 0003445439 scopus 로고    scopus 로고
    • 3rd ed. London: Edward Arnold, and New York: Wiley;
    • Goldstein H. Multilevel Statistical Models. 3 rd ed. London: Edward Arnold, and New York: Wiley ; 2003.
    • (2003) Multilevel Statistical Models
    • Goldstein, H.1
  • 29
    • 0028073689 scopus 로고
    • Pharmacokinetics of FK506 after intravenous and oral administration in patients awaiting renal transplantation
    • Gruber SA, Hewitt JM, Sorenson AL, et al. Pharmacokinetics of FK506 after intravenous and oral administration in patients awaiting renal transplantation. J Clin Pharmacol. 1994 ; 34: 859-864.
    • (1994) J Clin Pharmacol. , vol.34 , pp. 859-864
    • Gruber, S.A.1    Hewitt, J.M.2    Sorenson, A.L.3
  • 30
    • 0027418815 scopus 로고
    • Human P-glycoprotein transports cyclosporin a and FK506
    • Saeki T., Ueda K., Tanigawara Y., et al. Human P-glycoprotein transports cyclosporin A and FK506. J Biol Chem. 1993 ; 268: 6077-6080.
    • (1993) J Biol Chem. , vol.268 , pp. 6077-6080
    • Saeki, T.1    Ueda, K.2    Tanigawara, Y.3
  • 31
    • 0034693247 scopus 로고    scopus 로고
    • Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure
    • Huang Z., Murakami T., Okochi A., et al. Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure. Eur J Pharmacol. 2000 ; 406: 453-460.
    • (2000) Eur J Pharmacol. , vol.406 , pp. 453-460
    • Huang, Z.1    Murakami, T.2    Okochi, A.3
  • 32
    • 0036159876 scopus 로고    scopus 로고
    • Evaluation of increased bioavailability of tacrolimus in rats with experimental renal dysfunction
    • Okabe H., Yano I., Hashimoto Y., et al. Evaluation of increased bioavailability of tacrolimus in rats with experimental renal dysfunction. J Pharm Pharmacol. 2002 ; 54: 65-70.
    • (2002) J Pharm Pharmacol. , vol.54 , pp. 65-70
    • Okabe, H.1    Yano, I.2    Hashimoto, Y.3
  • 34
    • 0031783832 scopus 로고    scopus 로고
    • In vivo age-related changes in hepatic drug-oxidizing capacity in humans
    • Tanaka E. In vivo age-related changes in hepatic drug-oxidizing capacity in humans. J Clin Pharm Ther. 1998 ; 23: 247-255.
    • (1998) J Clin Pharm Ther. , vol.23 , pp. 247-255
    • Tanaka, E.1
  • 35
    • 0348226906 scopus 로고    scopus 로고
    • Age-related changes of the multidrug resistance p-glycoprotein function in normal human peripheral blood T-lymphocytes. Bras
    • Machado CG, Calado RT, Garcia AB, et al. Age-related changes of the multidrug resistance p-glycoprotein function in normal human peripheral blood T-lymphocytes. Bras J Med Biol Res. 2003 ; 36: 1653-1657.
    • (2003) J Med Biol Res , vol.36 , pp. 1653-1657
    • MacHado, C.G.1    Calado, R.T.2    Garcia, A.B.3
  • 36
    • 0035136948 scopus 로고    scopus 로고
    • Effect of low- and high-fat meals on tacrolimus absorption following 5 mg single oral doses to healthy human subjects
    • Bekersky I., Dressler D., Mekki QA Effect of low- and high-fat meals on tacrolimus absorption following 5 mg single oral doses to healthy human subjects. J Clin Pharmacol. 2001 ; 41: 176-182.
    • (2001) J Clin Pharmacol. , vol.41 , pp. 176-182
    • Bekersky, I.1    Dressler, D.2    Mekki, Q.A.3
  • 37
    • 33746829197 scopus 로고    scopus 로고
    • Is microparticle enzyme-linked immunoassay (MEIA) reliable for use in tacrolimus TDM? Comparison of MEIA to liquid chromatography with mass spectrometric detection using longitudinal trough samples from transplant recipients
    • Napoli KL Is microparticle enzyme-linked immunoassay (MEIA) reliable for use in tacrolimus TDM? Comparison of MEIA to liquid chromatography with mass spectrometric detection using longitudinal trough samples from transplant recipients. Ther Drug Monit. 2006 ; 28: 491-504.
    • (2006) Ther Drug Monit. , vol.28 , pp. 491-504
    • Napoli, K.L.1
  • 38
    • 1542329748 scopus 로고    scopus 로고
    • Factors affecting variability in distribution of tacrolimus in liver transplant recipients
    • Zahir H., McCaughan G., Gleeson M., et al. Factors affecting variability in distribution of tacrolimus in liver transplant recipients. Br J Clin Pharmacol. 2004 ; 57: 298-309.
    • (2004) Br J Clin Pharmacol. , vol.57 , pp. 298-309
    • Zahir, H.1    McCaughan, G.2    Gleeson, M.3
  • 39
    • 0036851317 scopus 로고    scopus 로고
    • Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-glycoprotein after high-dose steroid therapy
    • Shimada T., Terada A., Yokogawa K., et al. Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-glycoprotein after high-dose steroid therapy. Transplantation. 2002 ; 74: 1419-1424.
    • (2002) Transplantation , vol.74 , pp. 1419-1424
    • Shimada, T.1    Terada, A.2    Yokogawa, K.3
  • 40
    • 0029930064 scopus 로고    scopus 로고
    • Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber
    • Lampen A., Christians U., Gonschior AK, et al. Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber. Br J Pharmacol. 1996 ; 117: 1730-1734.
    • (1996) Br J Pharmacol. , vol.117 , pp. 1730-1734
    • Lampen, A.1    Christians, U.2    Gonschior, A.K.3
  • 41
    • 0036784516 scopus 로고    scopus 로고
    • Interaction of cytochrome P450 3A inhibitors with P-glycoprotein
    • Yasuda K., Lan L-B., Sanglard D., et al. Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 ; 303: 323-332.
    • (2002) J Pharmacol Exp Ther. , vol.303 , pp. 323-332
    • Yasuda, K.1    Lan, L.-B.2    Sanglard, D.3
  • 42
    • 0142212163 scopus 로고    scopus 로고
    • Disposition of tacrolimus in isolated perfused rat liver: Influence of troleandomycin, cyclosporine, and gg918
    • Wu CY, Benet LZ Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918. Drug Metab Dispos. 2003 ; 31: 1292-1295.
    • (2003) Drug Metab Dispos. , vol.31 , pp. 1292-1295
    • Wu, C.Y.1    Benet, L.Z.2
  • 43
    • 8544227674 scopus 로고    scopus 로고
    • Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1
    • Ito T., Yano I., Tanaka K., et al. Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J Pharmacol Exp Ther. 1997 ; 282: 955-960.
    • (1997) J Pharmacol Exp Ther. , vol.282 , pp. 955-960
    • Ito, T.1    Yano, I.2    Tanaka, K.3
  • 44
    • 33344471694 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between levofloxacin and ciclosporin or tacrolimus in kidney transplant recipients: Ciclosporin, tacrolimus and levofloxacin in renal transplantation
    • Federico S., Carrano R., Capone D., et al. Pharmacokinetic interaction between levofloxacin and ciclosporin or tacrolimus in kidney transplant recipients: ciclosporin, tacrolimus and levofloxacin in renal transplantation. Clin Pharmacokinet. 2006 ; 45: 169-175.
    • (2006) Clin Pharmacokinet. , vol.45 , pp. 169-175
    • Federico, S.1    Carrano, R.2    Capone, D.3
  • 45
    • 4143127834 scopus 로고    scopus 로고
    • Calcineurin inhibitor nephrotoxicity: Longitudinal assessment by protocol histology
    • Nankivell BJ, Borrows RJ, Fung CL, et al. Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology. Transplantation. 2004 ; 78: 557-565.
    • (2004) Transplantation , vol.78 , pp. 557-565
    • Nankivell, B.J.1    Borrows, R.J.2    Fung, C.L.3
  • 46
    • 0142106303 scopus 로고    scopus 로고
    • Transporter-enzyme interactions: Implications for predicting drug-drug interactions from in vitro data
    • Benet LZ, Cummins CL, Wu CY Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data. Curr Drug Metab. 2003 ; 4: 393-398.
    • (2003) Curr Drug Metab , vol.4 , pp. 393-398
    • Benet, L.Z.1    Cummins, C.L.2    Wu, C.Y.3
  • 47
    • 0242552696 scopus 로고    scopus 로고
    • Histologic features of mycophenolate mofetil-related colitis: A graft-versus-host disease-like pattern
    • Papadimitriou JC, Cangro CB, Lustberg A., et al. Histologic features of mycophenolate mofetil-related colitis: a graft-versus-host disease-like pattern. Int J Surg Pathol. 2003 ; 11: 295-302.
    • (2003) Int J Surg Pathol , vol.11 , pp. 295-302
    • Papadimitriou, J.C.1    Cangro, C.B.2    Lustberg, A.3
  • 48
    • 34547824092 scopus 로고    scopus 로고
    • Combination of CyP3A4 measurement in vivo and genetic stratification for p-glycoprotein explains 71% of the variability of dose/weight normalised Tacrolimus trough levels in renal transplant recipients [abstract]
    • Lemahieu Wpd, Maes BD, Verbeke K., et al. Combination of CyP3A4 measurement in vivo and genetic stratification for p-glycoprotein explains 71% of the variability of dose/weight normalised Tacrolimus trough levels in renal transplant recipients [abstract]. Am J Transplant. 2005 ; 5 (suppl 11). 390-391.
    • (2005) Am J Transplant , vol.5 , Issue.11 , pp. 390-391
    • Wpd, L.1    Maes, B.D.2    Verbeke, K.3
  • 49
    • 17644380257 scopus 로고    scopus 로고
    • Predicting drug disposition via application of BCS: Transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system
    • Wu CY, Benet LZ Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res. 2005 ; 22: 11-23.
    • (2005) Pharm Res. , vol.22 , pp. 11-23
    • Wu, C.Y.1    Benet, L.Z.2


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