Monosomy 7 in t(9;22)-negative cells during nilotinib therapy in an imatinib-resistant chronic myeloid leukemia case

Cancer Genetics and Cytogenetics

Volumn 176, Issue 2, 2007, Pages 169-171

  Zeidan, Amer ^a   Kakati, Surabhi ^b   Anderson, Barbara ^c   Barcos, Maurice ^d   Wetzler, Meir ^e  

^a Leukemia Section   (United States)

^b Clinical Cytogenetics Laboratory

^c Clinical Research Services   (Finland)

^d Department of Pathology ^*

^e ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DASATINIB; IMATINIB; INTERFERON; NILOTINIB;

ADULT; CASE REPORT; CHROMOSOME TRANSLOCATION 22; CHROMOSOME TRANSLOCATION 9; CHRONIC MYELOID LEUKEMIA; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; HUMAN; LETTER; LEUKEMOGENESIS; MONOSOMY 7; PRIORITY JOURNAL; THROMBOCYTOPENIA; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; ANEUGENS; ANTINEOPLASTIC AGENTS; CHROMOSOMES, HUMAN, PAIR 22; CHROMOSOMES, HUMAN, PAIR 7; CHROMOSOMES, HUMAN, PAIR 9; DISEASE PROGRESSION; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MONOSOMY; PIPERAZINES; PYRIMIDINES; TRANSLOCATION, GENETIC;

EID: 34447576744     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2006.12.011     Document Type: Letter

References (9)

1. Hagemeijer A., Smit E.M., Lowenberg B., and Abels J. Chronic myeloid leukemia with permanent disappearance of the Ph1 chromosome and development of new clonal subpopulations. Blood 53 (1979) 1-14
2. Fayad L., Kantarjian H., O'Brien S., Seong D., Albitar M., Keating M., and Talpaz M. Emergence of new clonal abnormalities following interferon-alpha induced complete cytogenetic response in patients with chronic myeloid leukemia: report of three cases. Leukemia 11 (1997) 767-771
3. Terre C., Eclache V., Rousselot P., Imbert M., Charrin C., Gervais C., Mozziconacci M.J., Maarek O., Mossafa H., Auger N., Dastugue N., Talmant P., Van den Akker J., Leonard C., Khac F.N., Mugneret F., Viguie F., Lafage-Pochitaloff M., Bastie J.N., Roux G.L., Nicolini F., Maloisel F., Vey N., Laurent G., Recher C., Vigier M., Yacouben Y., Giraudier S., Vernant J.P., Salles B., Roussi J., Castaigne S., Leymarie V., Flandrin G., Lessard M., and France Intergroupe pour la Leucémie Myéloïde Chronique (FILMC). Report of 34 patients with clonal chromosomal abnormalities in Philadelphia-negative cells during imatinib treatment of Philadelphia-positive chronic myeloid leukemia. Leukemia 18 (2004) 1340-1346
4. Medina J., Kantarjian H., Talpaz M., O'Brien S., Garcia-Manero G., Giles F., Rios M.B., Hayes K., and Cortes J. Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase. Cancer 98 (2003) 1905-1911
5. Bumm T., Muller C., Al-Ali H.K., Krohn K., Shepherd P., Schmidt E., Leiblein S., Franke C., Hennig E., Friedrich T., Krahl R., Niederwieser D., and Deininger M.W. Emergence of clonal cytogenetic abnormalities in Ph-cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority. Blood 101 (2003) 1941-1949
6. Lin Y., Bruyere H., Horsman D.E., Pantzar T., Barnett M.J., Hogge D.E., Nevill T.J., Nantel S.H., Sutherland H.J., Toze C.L., Shepherd J.D., Lavoie J.C., Song K.W., Smith C.A., and Forrest D.L. Philadelphia-negative clonal hematopoiesis following imatinib therapy in patients with chronic myeloid leukemia: a report of nine cases and analysis of predictive factors. Cancer Genet Cytogenet 170 (2006) 16-23
7. Kovitz C., Kantarjian H., Garcia-Manero G., Abruzzo L.V., and Cortes J. Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia. Blood 108 (2006) 2811-2813
8. Shafman T., Khanna K.K., Kedar P., Spring K., Kozlov S., Yen T., Hobson K., Gatei M., Zhang N., Watters D., Egerton M., Shiloh Y., Kharbanda S., Kufe D., and Lavin M.F. Interaction between ATM protein and c-Abl in response to DNA damage. Nature 387 (1997) 520-523
9. Yuan Z.M., Shioya H., Ishiko T., Sun X., Gu J., Huang Y.Y., Lu H., Kharbanda S., Weichselbaum R., and Kufe D. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 399 (1999) 814-817 [Erratum in: Nature 1999;400:792]