Exposure to the immunosuppresant, perfluorooctanoic acid, enhances the murine IgE and airway hyperreactivity response to ovalbumin

Toxicological Sciences

Volumn 97, Issue 2, 2007, Pages 375-383

  Fairley, Kimberly J ^a   Purdy, Rich ^b   Kearns, Shaun ^a   Anderson, Stacey E ^a   Meade, B J ^a,c  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b Baldur Toxicology   (United States)

^c NONE   (United States)

Author keywords

Airway hyperreactivity; IgE; Ovalbumin; Perfluorooctanoic acid

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E; MUCIN; OVALBUMIN; PERFLUOROOCTANOIC ACID; ANTIGEN; FLUOROCARBON; IMMUNOSUPPRESSIVE AGENT; OCTANOIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EOSINOPHILIA; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOMODULATION; IMMUNOTOXICITY; LIVER WEIGHT; MOUSE; NONHUMAN; ORGAN WEIGHT; PROTEIN SYNTHESIS; SPLEEN WEIGHT; THYMUS; TOXIN ANALYSIS; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; BODY WEIGHT; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPERSENSITIVITY; IMMUNOLOGY; LUNG; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; RESPIRATORY TRACT ALLERGY; TOPICAL DRUG ADMINISTRATION;

ANIMALIA; MURINAE; MUS;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIGENS; ASTHMA; BODY WEIGHT; BRONCHIAL HYPERREACTIVITY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUOROCARBONS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; IMMUNOSUPPRESSIVE AGENTS; LUNG; MICE; MICE, INBRED BALB C; OCTANOIC ACIDS; ORGAN SIZE; OVALBUMIN; PHENOTYPE; RESPIRATORY HYPERSENSITIVITY;

EID: 34447574868     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm053     Document Type: Article

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