Induction of promotive rather than suppressive immune responses from a novel NKT cell repertoire Vα19 NKT cell with α-mannosyl ceramide analogues consisting of the immunosuppressant ISP-I as the sphingosine unit

European Journal of Medicinal Chemistry

Volumn 41, Issue 5, 2006, Pages 569-576

  Shimamura, Michio ^a   Okamoto, Naoki ^a   Huang, Yi Ying ^a   Yasuoka, Jouji ^b   Morita, Kenji ^b   Nishiyama, Akira ^b   Amano, Yuusuke ^b   Mishina, Tadashi ^b  

^a MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

^b MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

glycosphingolipid; immunomodulation; NKT cell

Indexed keywords

CERAMIDE DERIVATIVE; ETHANOLAMINE; GLYCOSIDE; IMMUNOSUPPRESSIVE AGENT; INTRACELLULAR SERINE PROTEASE 1; MANNOSE; SPHINGOSINE; UNCLASSIFIED DRUG; CERAMIDE; MONOSACCHARIDE; MONOUNSATURATED FATTY ACID; THERMOZYMOCIDIN;

ANIMAL CELL; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; IMMUNE RESPONSE; LYMPHOCYTE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; TRANSGENIC MOUSE; ANIMAL; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; IMMUNOLOGY; REGULATORY T LYMPHOCYTE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; CELLS, CULTURED; CERAMIDES; FATTY ACIDS, MONOUNSATURATED; IMMUNOSUPPRESSIVE AGENTS; MICE; MOLECULAR STRUCTURE; MONOSACCHARIDES; SPHINGOSINE; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES, REGULATORY;

EID: 33646756515     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.11.013     Document Type: Article

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