In vitro evaluation of human cytochrome P450 and P-glycoprotein-mediated metabolism of some phytochemicals in extracts and formulations of African potato

Phytomedicine

Volumn 14, Issue 7-8, 2007, Pages 498-507

  Nair, Vipin D P ^a   Foster, Brian C ^b   Thor Arnason, J ^b   Mills, Edward J ^c   Kanfer, Isadore ^a  

^a RHODES UNIVERSITY   (South Africa)

^b UNIVERSITY OF OTTAWA   (Canada)

^c CANADIAN COLLEGE OF NATUROPATHIC MEDICINE   (Canada)

Author keywords

sitosterol; Drug interactions; Hypoxis hemerocallidea; Hypoxoside; Rooperol; Stigmasterol

Indexed keywords

AFRICAN POTATO EXTRACT; ALPHA TOCOPHEROL; AROMATASE; ASCORBIC ACID; CYANOCOBALAMIN; CYTOCHROME P450; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; FLUORESCENT DYE; GINSENG EXTRACT; GLYCOPROTEIN P; HYPOXOSIDE; NORLIGNAN GLYCOSIDE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; PYRIDOXINE; RETINOL; RHODAMINE 123; RIBOFLAVIN; RITONAVIR; ROOPEROL; SELENIUM; SITOSTANOL; SITOSTEROL; STANOL ESTER; STEROL DERIVATIVE; STIGMASTEROL; THIAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VITAMIN D;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG FORMULATION; DRUG METABOLISM; HERB; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; POTATO; PRIORITY JOURNAL; PROTEIN INDUCTION; TRADITIONAL MEDICINE;

CACO-2 CELLS; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; HYPOXIS; MOLECULAR STRUCTURE; P-GLYCOPROTEIN; PLANT EXTRACTS; RITONAVIR;

HYPOXIS HEMEROCALLIDEA; SOLANUM TUBEROSUM;

EID: 34447569541     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2006.12.004     Document Type: Article

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