Preclinical evaluation of sodium cellulose sulfate (Ushercell) as a contraceptive antimicrobial agent

Journal of Andrology

Volumn 23, Issue 3, 2002, Pages 426-438

  Anderson, Robert A ^a   Feathergill, Kenneth A ^b   Diao, Xaio Hui ^c   Cooper, Morris D ^d   Kirkpatrick, Risa ^e   Herold, Betsy C ^d   Doncel, Gustavo F ^f   Chany, Calvin J ^f   Waller, Donald P ^c   Rencher, William F ^d   Zaneveld, Lourens J D ^d  

^a Ob Gyn Research   (United States)

^b Department of Tropical Medicine ^*  (United States)

^c DIVISION OF REPRODUCTIVE BIOLOGY   (United States)

^d RUSH UNIVERSITY MEDICAL CENTER   (United States)

^e RESEARCH AND DEVELOPMENT   (Australia)

^f UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Antifertility; Chlamydia; HIV; HSV; Microbicide; N. gonorrhoeae

Indexed keywords

CELLULOSE SULFATE; CONTRACEPTIVE AGENT; HYALURONIDASE; SODIUM CELLULOSE SULFATE; UNCLASSIFIED DRUG;

ACROSOME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; CHLAMYDIA TRACHOMATIS; CONTRACEPTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG SAFETY; HERPES SIMPLEX VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; MALE; NEISSERIA GONORRHOEAE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROPHYLAXIS; RABBIT; SEXUALLY TRANSMITTED DISEASE; SPERMATOZOON; SPERMATOZOON PENETRATION; UTERINE CERVIX MUCUS;

ACROSOME; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIVIRAL AGENTS; CELLULOSE; CHLAMYDIA INFECTIONS; CONTRACEPTIVE AGENTS, FEMALE; ENZYME INHIBITORS; HERPES SIMPLEX; HIV INFECTIONS; HYALURONOGLUCOSAMINIDASE; LACTOBACILLUS; MALE; RABBITS; SEXUALLY TRANSMITTED DISEASES, BACTERIAL; SPERMATOZOA;

EID: 0036217080     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (93)

1. Estudio del efecto de una nueva asociacion contraceptiva sobre los espermatozoides humanos
2. Trichomonas vaginalis surface proteinase activity is necessary for parasite adherence to epithelial cells
3. Polysaccharide polysulphuric acids as antihyaluronidases
4. Factors influencing the activity of testicular hyaluronidase
5. Acrosin inhibitor, 4′-acetamidophenyl 4-guanidinobenzoate, an experimental vaginal contraceptive with anti-HIV activity
6. Effect of serine protease inhibitor, N-α-tosyl-L-lysyl-chloromethyl ketone (TLCK), on cell-mediated and cell-free HIV-1 spread
7. Comparing contraceptive use surveys of young people in the United Kingdom
8. Do spermicides containing nonoxynol-9 prevent sexually transmitted infections? A meta-analysis
9. Chlamydia trachomatis infection of human fallopian tube organ cultures
10. Human immunodeficiency virus-related risk behavior among African-American females
11. Heparin binding sites in the human spermatozoa membrane
12. Practical experience with a new vaginal contraceptive
13. Further evidence for hyaluronidase activity of Treponema pallidum
14. The hyaluronidase associated with Treponema pallidum facilitates treponemal dissemination
15. The promise of public/private sector collaboration in the development of vaginal microbicides
16. The effects of serum and of hyaluronc acid derivatives on the action of hyaluronidase
17. 3H-heparin to bull, monkey, and rabbit spermatozoa in vitro
18. Structural comparisons among glycosaminoglycans to promote an acrosome reaction in bovine spermatozoa
19. Involvement of tryptase-related cellular protease(s) in human immunodeficiency virus type 1 infection
20. Differences in the susceptibility of herpes simplex virus types 1 and 2 to modified heparin compounds suggest serotype differences in viral entry
21. The inhibitory effect of spermicidal agents on replication of HSV-2 and HIV-1 in-vitro
22. Building barriers to HIV
23. Identification and functions of mammalian sperm-egg-recognition molecules during fertilization
24. Contraceptive effects of intravaginal application of acrosin and hyaluronidase inhibitors in rabbit
25. Vaginal contraceptive activity of hyaluronidase and cyclooxygenase (prostaglandin synthetase) inhibitors in the rabbit
26. In vitro evaluations of condoms with and without nonoxynol 9 as physical and chemical barriers against Chlamydia trachomatis, herpes simplex virus type 2, and human immunodeficiency virus
27. Vaginal contraceptive activity of aryl 4-guanidinobenzoates (acrosin inhibitors) in rabbits
28. Viricidal effect of Lactobacillus acidophilus on human immunodeficiency virus type 1: Possible role in heterosexual transmission
29. Inactivation of human immunodeficiency virus type 1 by nonoxynol-9, C31G, or an alkyl sulfate, sodium dodecyl sulfate
30. Efficacy of nonoxynol-9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes
31. New capsule with tailored properties for the encapsulation of living cells
32. Relationship between heparin binding characteristics and ability of human spermatozoa to penetrate hamster ova
33. Antithrombin III enhances the motility and chemotaxis of boar sperm
34. Chondroitin sulfate facilitates an acrosome reaction in bovine spermatozoa as evidenced by light microscopy, electron microscopy and in vitro fertilization
35. Rabbit spermatozoa undergo an acrosome reaction in the presence of glycoaminoglycans
36. Bacterial mucopolysaccharidases (mucopolysaccharide lyases)
37. Inactivation of HIV by nonoxynol-9
38. Possible interaction between animal lectins and bacterial carbohydrates
39. The vaginal ecosystem
40. Relationship of nonreturn rates of dairy bulls to binding affinity of heparin to sperm
41. Animal mucopolysaccharidases
42. Glycosaminoglycans stimulate the acrosome reaction of previously capacitated hamster sperm
43. A new method for the encapsulation of mammalian cells
44. Relationship of heparin binding with computer-analyzed physical traits of human sperm
45. Sulfated homopolysaccharides with immunomodulating activities are more potent anti-HTLV-III agents than sulfated heteropolysaccharides
46. Anti-AIDS drug development: Challenges and strategies
47. Nature of the inhibitory effect of complex saccharide moieties on the tight binding of human spermatozoa to the human zona pellucida
48. Proteases of the pathogenic Neisseriae: Possible role in infection
49. Prevention of fertilization by a hyaluronidase inhibitor
50. Capacitation of bovine sperm by heparin
51. Effect of sulfated glycoconjugates on capacitation and the acrosome reaction of bovine and hamster spermatozoa
52. Sulfated polysaccharides inhibit lymphocyte-to-epithelial transmission of human immunodeficiency virus-1
53. The effects of hyaluronidase inhibitors on fertilization in the rabbit
54. In vitro inactivation of HIV-1 by contraceptive sponge containing nonoxynol-9
55. Treponema pallidum in human chancre tissue: An electron microscopic survey
56. Functional biochemistry of cervical mucus
57. Relationship between heparin binding characteristics and hamster ova penetrating capacity of human spermatozoa
58. Anti-HIV screening technology
59. A controlled trial of nonoxynol 9 film to reduce male-to-female transmission of sexually transmitted diseases
60. Capacitation, acrosome reaction, and fertilization
61. Synthetic polyanionic inhibitors of hyaluronidase
62. Vaginal hyaluronidase activity in some pathological conditions. III. Cervico-vaginitis
63. Microbial adherence to and invasion through proteoglycans
64. A practical method for testing the spermicidal action of chemical contraceptives
65. Knowledge of HIV serostatus and preventive behaviour among European injecting drug users: Second study
66. Herpes virus-induced cell fusion that is dependent on cell surface heparan sulfate or soluble heparin
67. Cell surface receptors for Herpes simplex virus are heparan sulfate proteoglycans
68. A new antifertility factor (a preliminary report)
69. Contraceptive use and pregnancy decision making among women with HIV
70. Membrane fusion induced by Herpes simplex virus
71. Enzyme inhibition
72. A zymographic assay for detection of hyaluronidase activity on polyacrylamide gels and its application to enzymatic activity found in bacteria
73. Widely used spermicide may increase, not decrease, risk of HIV transmission
74. Effect of follicular fluid on the kinetics of the human sperm acrosome reaction in vitro
75. Heparan sulfate proteoglycans on the cell surface: Versatile coordinators of cellular functions
76. Prophylactic contraceptives for HIV/AIDS
77. Correlation of human spermatozoa heparin binding with the zona-free hamster egg in vitro penetration assay
78. In-vitro penetration of pig oocytes matured in culture by frozen-thawed ejaculated spermatozoa
79. Sulfated polysaccharides extracted from sea algae as potential antiviral drugs
80. Extent of vaginal absorption of sulphated polysaccharide from A-Gen 53 in the rabbit
81. Initial interaction of Herpes simplex virus with cells is binding to heparan sulfate
82. Synthesis, structure and antiviral activity of sulfates of cellulose and its branched derivatives
83. Mammalian fertilization
84. Sperm enzyme inhibitors for vaginal and other contraception
85. Trypsin inhibitors and fertilization
86. Tests of vaginal microbicides in the mouse genital herpes model
87. Barrier contraceptive use and HIV infection among high-risk women in Cameroon
88. Inhibition of hyaluronidase by dextran sulfate and its possible application in anticancer treatment