Numerical simulation on mass transport in a microchannel bioreactor for co-culture applications

Journal of Biomechanical Engineering

Volumn 129, Issue 3, 2007, Pages 365-373

  Zeng, Yan ^a   Lee, Thong See ^a   Yu, Peng ^a   Low, Hong Tong ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Co culture cell growth; Microchannel bioreactor; Species concentration

Indexed keywords

ABSORPTION CELLS; FLUID MICROENVIRONMENT; FLUX-PARAMETER; ZEROTH ORDER REACTION;

CELL GROWTH; COMPUTER SIMULATION; MASS TRANSFER; MICROCHANNELS; PARAMETER ESTIMATION;

BIOREACTORS;

ARTICLE; BIOREACTOR; CELL CULTURE; CELL FUNCTION; CELL GROWTH; CELL TYPE; MASS; MATHEMATICAL MODEL; MICHAELIS CONSTANT; MICROENVIRONMENT; SIMULATION;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL PHYSIOLOGY; CELLS, CULTURED; COCULTURE TECHNIQUES; COMPUTER SIMULATION; HUMANS; KINETICS; MICROFLUIDIC ANALYTICAL TECHNIQUES;

EID: 34447539586     PISSN: 01480731     EISSN: None     Source Type: Journal    
DOI: 10.1115/1.2720913     Document Type: Article

References (19)

1. Bhatia, S. N., Balis, U. J., Yarmush, M. L., and Toner, M., 1998, "Microfabrication of Hepatocyte/Fibroblast Co-cultures: Role of Homotypic Cell Interactions," Biotechnol. Prog., 14, pp. 378-387.
2. Houssaint, E., 1990, "Differentiation of the Mouse Hepatic Primordium. I. An Analysis of Tissue Interactions in Hepatocyte Differentiation," Cell Differ, 9, pp. 269-279.
3. Aufderheide, E., Chiquet-Ehrismann, R., and Ekblom, P., 1987, "Epithelial-Mesenchymal Interactions in the Developing Kindey Lead to Expression of Terascin in the Mesenchyme," J. Cell Biol., 105, pp. 599-608.
4. Fillinger, M. F., O'Connor, S. E., Wagner, R. J., and Cronenvett, J. L., 1993, "The Effect of Endothelial Cell Coculture on Smooth Muscle Cell Proliferation," J. Vasc. Surg., 17, pp. 1058-1068.
5. Guguen-Guillouzo, C., Clement, B., Baffet, G., Beaumont, C., Morchel-Chany, E., Glaise, D., and Guillouzo, A., 1983, "Maintenance and Reversibility of Active Albumin Secretion by Adult Rat Hepatocytes Co-cultured With Another Liver Epithelial Cell Type," Exp. Cell Res., 143, pp. 47-54.
6. Donato, M. T., Gómez-Lechón, M. J., and Castell, J. V., 1990, "Drug Metabolizing Enzymes in Rat Hepatocytes Co-cultured With Cell Lines," In Vitro Cell Dev. Biol., 26, pp. 1057-1062.
7. Matsuo, R., Ukida, M., Nishikawa, Y., Omori, N., and Tsuji, T., 1992, "The Role of Kupffer Cells in Complement in D-Galactosamine/ Lipopolysaccharide-Induced Hepatic Injury of Rats," Acta Med. Okayama, 46, pp. 345-354.
8. Rojkind, M., Novikoff, P. M., Greenwel, P., Rubin, J., Rojas-Valencia, L., de Carvalho, A. C., Stockert, R., Spray, D., Hertzberg, E. L., and Wolkof, A. W., 1995, "Characterization and Functional Studies on Rat Liver Fat-storing Cell Line and Freshly Isolated Hepatocyte Coculture System," Am. J. Pathol., 146(6), pp. 1508-1520.
9. Folch, A., and Toner, M., 2000, "Microengineering of Cellular Interactions," Annu. Rev. Biomed. Eng., 2, pp. 227-256.
10. Roy, P., Baskaran, H., Tilles, A. W., Yarmush, M. L., and Toner, M., 2001, "Analysis of Oxygen Transport to Hepatocytes in a Flat-Bed MicroChannel Bioreactor," Ann. Biomed. Eng., 29, pp. 947-955.
11. Ledezma, G. A., Folch, A., Bhatia, S. N., Balis, U. J., Yarmush, M. L., and Toner, M., 1999, "Numerical Model of Fluid Flow and Oxygen Transport in a Radial-Flow MicroChannel containing Hepatocytes," ASME J. Biomech. Eng., 121, pp. 58-64.
12. Zeng, Y., Lee, T. S., Yu, P., and Low, H. T., 2006, "Mass Transport and Shear Stress in a MicroChannel Bioreactor: Numerical Simulation and Dynamic Similarity," ASME J. Biomech. Eng., 128, pp. 185-193.
13. Tilles, A. W., Baskaran, H., Roy, P., Yarmush, M. L., and Toner, M., 2001, "Effects of Oxygenation and Flow on the Viability and Function of Rat Hepatocytes Co-cultured in a MicroChannel Flat-plate Bioreactor," Biotechnol. Bioeng., 73, pp. 379-389.
14. Allen, J. W., Khetani, S. R., and Bhatia, S. N., 2005, "In Vitro Zonation and Toxicity in a Hepatocyte Bioreactor," Toxicol. Sci., 84, pp. 110-119.
15. Balis, U. J., Behnia, K., Dwarakanath, B., Bhatia, S. N., Sullivan, S. J., Yarmush, M. L., and Toner, M., 1999, "Oxygen Consumption Characteristics of Porcine Hepatocytes," Metab. Eng., 1, pp. 49-62.
16. Nollert, M. U., Diamond, S. L., and McIntire, L. V., 1991, "Hydrodynamic Shear Stress and Mass Transport Modulation of Endothelial Cell Metabolism," Biotechnol. Bioeng., 38, pp. 588-602.
17. Nollert, M. U., and McIntire, L. V., 1992, "Convective Mass Transfer Effects on the Intracellular Calcium Response of Endothelial Cells," ASME J. Biomech. Eng., 114, pp. 321-326.
18. Holden, M. A., Kumar, S., Castellana, E. T., Beskok, A., and Cremer, P. S., 2003, "Generating Fixed Concentration Arrays in a Microfluidic Device," Sens. Actuators B, 92, pp. 199-207.
19. Patankar, S. V., 1980, Numerical Heat Transfer and Fluid Flow, Hemisphere, New York.