Simultaneous quantification of oxysophocarpine and its active metabolite sophocarpine in rat plasma by liquid chromatography/mass spectrometry for a pharmacokinetic study

Biomedical Chromatography

Volumn 21, Issue 7, 2007, Pages 768-774

  Wang, Su Jun ^a,c   Yang, Min ^b   Li, Xiao Tian ^c   Wang, Guang Ji ^c  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b JIANGSU INSTITUTE OF NUCLEAR MEDICINE   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

LC ESI MS; Oxysophocarpine; Pharmacokinetics; Sophocarpine

Indexed keywords

BODY FLUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PHARMACOKINETICS; RATS;

ACTIVE METABOLITES; ANALYTES; LC-ELECTROSPRAY IONIZATION-MS; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; LIQUID CHROMATOGRAPHY ELECTROSPRAY; LIQUID-LIQUID EXTRACTION PROCEDURE; OXYSOPHOCARPINE; PHARMACOKINETIC STUDIES; RAT PLASMA; SOPHOCARPINE;

ELECTROSPRAY IONIZATION;

ALKALOID DERIVATIVE; DRUG METABOLITE; MATRINE; OXYSOPHOCARPINE; SOPHOCARPINE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS;

RATTUS;

EID: 34447524851     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.820     Document Type: Article

References (11)

1. Cui JF, Zhang GD and Wang MZ. HPLC and TLC-densitometry determination of alkaloidal constituents in Sophora flavescens and Sophora lopecuroides. Yao Xue Xue Bao 1985; 20: 59-66.
2. Ding PL, Yu YQ and Chen DF. Determination of quinolizidine alkaloids in Sophora tonkinensis by HPCE. Phytochemical Analysis 2005; 16: 257-263.
3. Guo B, Li C, Deng Z, Chen S, Ji Z, Zhang J, Chen M and Xu F. A new method for measurement of (-)-sophocarpine, a candidate therapeutic for viral myocarditis, in plasma: application to a toxicokinetic study in beagle dogs. Rapid Communications in Mass Spectrometry 2005: 19: 2840-2848.
4. Jin LX, Cui YY and Zhang GD. HPLC analysis of alkaloids in Sophora flavescens Ait. Yao Xue Xue Bao 1993; 28: 136-139.
5. Ma RL, Zhou HH, Yu XS and Sheng LS. Study on the fingerprints of the alkaloids in Sophora flavescens. Zhongguo Zhong Yao Za Zhi 2003; 28: 817- 819.
6. Song JZ, Xu HX, Tian SJ and But PP. Determination of quinolizidine alkaloids in traditional Chinese herbal drugs by nonaqueous capillary electrophoresis. Journal of Chromatography A. 1999;857: 303-311.
7. Wang S, Wang G, Li X, Sun J, Ma R and Sheng L. Phamacokinetics of oxymatrine in Beagle dogs by LC-MS. Chinese Journal of Clinical Pharmacology and Therapeutics 2004; 9: 751-754.
8. Wang S, Wang G, Li X, Sun J, Ma R and Sheng L. Simultaneous determination of oxymatrine and its active metabolite matrine in dog plasma by liquid chromatography-mass spectrometry and its application to pharmacokinetic studies. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences 2005; 817: 319-325.
9. Wu YJ, Chen JJ and Cheng YY. A sensitive and specific HPLC-MS method for the determination of sophoridine, sophocarpine and matrine in rabbit plasma. Analytical and Bioanalytical Chemistry 2005; 382: 1595-1600.
10. Xu X and Jiang J. Progress in the study of antineoplastic activity of suphora flarescens ait and its alkaloids. Zhongguo Zhong Xi Yi Jie He Za Zhi 1998; 18: 314-316.
11. Zhang L, Li G, Houghton PJ, Jackson S and Twentyman PR. Alkaloids in Sophora alopecuroides seed and relevant tests for activity. Zhongguo Zhong Yao Za Zhi 1997;22(12): 740-743, 764.