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Volumn 19, Issue 4, 2007, Pages 488-491

Regulation of phosphate homeostasis in infants, children, and adolescents, and the role of phosphatonins in this process

Author keywords

Hyperphosphatemia; Hypophosphatemic rickets; Phosphate homeostasis; Phosphatonin

Indexed keywords

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 23; PHOSPHATE; VITAMIN D;

EID: 34447507731     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOP.0b013e328270b902     Document Type: Review
Times cited : (13)

References (21)
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    • White KE, Larsson TM, Econs MJ. The roles of specific genes implicated as circulating factors involved in normal and disordered phosphate homeostasis: frizzled related protein-4, matrix extracellular phosphoglycoprotein, and fibroblast growth factor 23. Endocr Rev 2006; 27:221-241. An excellent and extensive review on phosphatonins and their effect on phosphate homeostasis.
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    • •] work, the invalidation of a vitamin D gene prevents ectopic calcification and abnormal phosphorus and calcium metabolism. In addition, invalidation of the fgf23 gene may increase the animal responses to subcutaneous glucose tolerance tests and insulin secretion, changes that also require an intact vitamin D signaling pathway.
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    • Burnett SA, Gunawardene SC, Bringhurst FR, et al. Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women. J Bone Miner Res 2006; 21:1187-1196. This study in healthy adults shows a 50% increase in circulating fgf23 within 1-3 days following an increase in phosphate intake from 900 mg to 2.5 g/day, as well as a 25% decrease after phosphate depletion. It also confirms that the choice of the fgf23 assay is critical, the assay detecting only the intact fgf23 peptide giving the best results.
    • Burnett SA, Gunawardene SC, Bringhurst FR, et al. Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women. J Bone Miner Res 2006; 21:1187-1196. This study in healthy adults shows a 50% increase in circulating fgf23 within 1-3 days following an increase in phosphate intake from 900 mg to 2.5 g/day, as well as a 25% decrease after phosphate depletion. It also confirms that the choice of the fgf23 assay is critical, the assay detecting only the intact fgf23 peptide giving the best results.


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