Insulin-Like Growth Factor I in the Kidney

Mineral and Electrolyte Metabolism

Volumn 22, Issue 1-3, 1996, Pages 128-132

  Hirschberg, Raimund ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Extracellular matrix; Glomerular filtration; IGF binding proteins; Nephron growth; Nephrotic syndrome; Tubule transport

Indexed keywords

SOMATOMEDIN C;

BIOSYNTHESIS; CONFERENCE PAPER; DRUG BLOOD LEVEL; GLOMERULUS FILTRATION RATE; HISTOCHEMISTRY; KIDNEY; LIVER; PHOSPHATE TRANSPORT; PRIORITY JOURNAL; PROTEIN BINDING;

ANIMAL; ARTERIOLES; GLOMERULAR FILTRATION RATE; HUMAN; INSULIN-LIKE GROWTH FACTOR I; KIDNEY; KIDNEY DISEASES; KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; LIPOPROTEIN(A); NEPHRONS; NEPHROTIC SYNDROME; PHOSPHATES; RENAL CIRCULATION; VASCULAR RESISTANCE;

EID: 0029656129     PISSN: 03780392     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (23)

1. Roberts C, Lasky S, Lowe W, Seaman W, LeRoith D: Molecular cloning of rat insulinlike growth factor I complementary deoxyribonucleic acids: Differential messenger ribonucleic acid processing : and regulation by growth hormone in extrahepatic tissues, Mol Endocrinol 1987;1:243-248.
2. Conti F, Elliot S, Striker L, Striker G: Binding, of insulin-like growth factor by glomerular endothelial and epithelial cells: further evidence for IGF-I action in the renal glomerulus. Biochem Biophys Res Commun 1989;163:952-958.
3. Hammerman M, Rogers S: Distribution of IGF receptors in the plasma membrane of proximal tubule .cells. Am J Physil 1987;253:F841-F847.
4. Chin E, Zhou J, Bondy C: Anatomical relationships in the patterns of insulin-like growth factor (IGF)-I, IGF binding protein-1, and IGF-I receptor gene expression in the rat kidney. Endocrinology 1992;130:3237-3245.
5. Shimasaki S, Ling N: Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6). Progr Growth Factor Res 1991;3:243-266.
6. Blat C, Villaudy J, Binoux M: In vivo proteolysis of serum insulin-like growth factor (IGF) binding protein-3 results in increased availability of IGF to target cells. J Clin Invest 1994;93:2286-2290.
7. Hirschberg R, Kopple J: Evidence that insulinlike growth factor I increases renal plasma flow and glomerular filtration rate in fasted rats. J Clin Invest 1989;83:326-330.
8. Hirschberg R, Brunori G, Kopple J, Guler H: Effects of insulin-like growth factor I on renal function in normal men. Kidney Int 1993;43:387-397.
9. Hirschberg R, Kopple J, Blantz R, Tucker B: Effects of recombinant human insulin-like growth factor I on glomerular dynamics in the rat. J Clin Invest 1991;87:1200-1206.
10. Guler H, Eckardt K, Zapf J, Bauer C, Froesch E: Insulin-like growth factor I increases glomerular filtration rate and renal plasma flow in man. Acta Endocrinol (Copenh) 1989;121:101-106.
11. Haylor J, Singh I, El Nahas A: Nitric oxide synthesis inhibitor prevents vasodilation by insulin-like growth factor I Kidney Int 1991;39:333-335.
12. Hirschberg R, Kopple J: The growth hormone-insulin-like growth factor I axis and renal glomerular function. J Am Soc Nephrol 1992;2:1417-1422.
13. Hirschberg R: Effects of growth hormone and IGF-I on glomerular ultrafiltration in growth hormone-deficient rats. Regul Pept 1993;48:241-250.
14. Caverzasio J, Bonjour J: Insulin-like growth factor I stimulates Na-dependent Pi transport in cultured kidney cells. Am J Physiol 1989.
15. Hirschberg R, Ding H, Wanner C: Effects of Insulin-like growth factor I on phosphate transport in cultured proximal tubule cells. J Lab Clin Med 1995, in press.
16. Quigley R, Baum M: Effects of growth hormone and insulin-like growth factor I on rabbit proximal convoluted tubule transport. J Clin Invest 1991;88:368-374.
17. Flyvbjerg A, Orskov H, Nyborg K, Frystyk J, Marshall S, Barnfeld K, Arnqvist H, Jorgensen K: Kidney IGF-I accumulation occurs in four different conditions with rapid initial kidney growth in rats; in Spencer E (ed): Modern Concepts of Insulin-Like Growth Factors. New York, Elsevier, 1991.
18. Mulroney S, Haramati A, Werner H, Bondy C, Roberts C, LeRoith D: Altered expression of insulin-like growth factor I (IGF-I) and IGF receptor genes after unilateral nephrectomy in immature rats. Endocrinology 1992;130:249-256.
19. Feld S, Hirschberg R, Artishevsky A, Nast C, Adler S: IGF-I induces mesangial cell proliferation and increases mRNA and secretion of collagen. J Am Soc Nephrol 1993;4:464.
20. Hirschberg R, Nast C: Glomerular hypertrophy and segmental glomerular sclerosis are not linked in subtotally nephrectomized rats. J Am Soc Nephrol 1992;3:739.
21. Garin E, Grant M, Silverstein J: Insulin-like growth factors in patients with active nephrotic syndrome. Am J Dis Childr 1989;143:865-867.
22. Hirschberg R: IGF-I is ultrafiltered into the urinary space and may exert biological effects in proximal tubules in the nephrotic syndrome. J Am Soc Nephrol 1993;4:771.
23. Hirschberg R, Kaysen G: Insulin-like growth factor I and its binding proteins in the experimental nephrotic syndrome. Endocrinology 1995;136:1565-1571.