메뉴 건너뛰기




Volumn 75, Issue 6, 2007, Pages 343-350

Effective acute stroke treatment beyond approval limitations: Intravenous thrombolysis within an extended time window (3-6 h) and in old patients (aged 80 or older);Effektive schlaganfalltherapie jenseits der zulassungsbeschränkungen: Intravenöse thrombolyse im erweiterten zeitfenster (> 3 h) und bei alten patienten (≥80 J.)

Author keywords

Aged, 80 and over; Diffusion and perfusion weighted MRI; Stroke, acute; Thrombolytic therapy

Indexed keywords

DESMOTEPLASE; FIBRINOLYTIC AGENT; PLACEBO; TISSUE PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR;

EID: 34447504623     PISSN: 07204299     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-959182     Document Type: Review
Times cited : (9)

References (57)
  • 1
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke
    • The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
    • The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333: 1581-1587
    • (1995) N Engl J Med , vol.333 , pp. 1581-1587
  • 2
    • 1542315556 scopus 로고    scopus 로고
    • Kummer R von, Broderick JP, Brott T, Frankel M, Grotta JC, Haley EC Jr, Kwiatkowski T, Levine SR, Lewandowski C, Lu M, Lyden P, Marler JR, Patel S, Tilley BC, Albers G, Bluhmki E, Wilhelm M, Hamilton S. Association of outcome with early stroke treatment: Pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials
    • Hacke W, Donnan G, Fieschi C, Kaste M, Kummer R von, Broderick JP, Brott T, Frankel M, Grotta JC, Haley EC Jr, Kwiatkowski T, Levine SR, Lewandowski C, Lu M, Lyden P, Marler JR, Patel S, Tilley BC, Albers G, Bluhmki E, Wilhelm M, Hamilton S. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 2004; 363: 768-774
    • (2004) Lancet , vol.363 , pp. 768-774
    • Hacke, W.1    Donnan, G.2    Fieschi, C.3    Kaste, M.4
  • 3
    • 0345599248 scopus 로고    scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke in clinical practice: A meta-analysis of safety data
    • Graham GD. Tissue plasminogen activator for acute ischemic stroke in clinical practice: a meta-analysis of safety data. Stroke 2003; 34: 2847-2850
    • (2003) Stroke , vol.34 , pp. 2847-2850
    • GD, G.1
  • 4
    • 33745934529 scopus 로고    scopus 로고
    • Comparison of tissue plasminogen activator administration management between Telestroke Network hospitals and academic stroke centers: The Telemedical Pilot Project for Integrative Stroke Care in Bavaria/Germany
    • Audebert HJ, Kukla C, Vatankhah B, Gotzler B, Schenkel J, Hofer S, Furst A, Haberl RL. Comparison of tissue plasminogen activator administration management between Telestroke Network hospitals and academic stroke centers: the Telemedical Pilot Project for Integrative Stroke Care in Bavaria/Germany. Stroke 2006; 37: 1822-1827
    • (2006) Stroke , vol.37 , pp. 1822-1827
    • Audebert, H.J.1    Kukla, C.2    Vatankhah, B.3    Gotzler, B.4    Schenkel, J.5    Hofer, S.6    Furst, A.7    Haberl, R.L.8
  • 6
    • 0034888230 scopus 로고    scopus 로고
    • Treatment with tissue plasminogen activator and inpatient mortality rates for patients with ischemic stroke treated in community hospitals
    • Reed SD, Cramer SC, Blough DK, Meyer K, Jarvik JG. Treatment with tissue plasminogen activator and inpatient mortality rates for patients with ischemic stroke treated in community hospitals. Stroke 2001; 32: 1832-1840
    • (2001) Stroke , vol.32 , pp. 1832-1840
    • Reed, S.D.1    Cramer, S.C.2    Blough, D.K.3    Meyer, K.4    Jarvik, J.G.5
  • 8
    • 0033962916 scopus 로고    scopus 로고
    • Treating acute stroke patients with intravenous tPA. The OSF stroke network experience
    • Wang DZ, Rose JA Honings DS, Garwacki DJ, Milbrandt JC. Treating acute stroke patients with intravenous tPA. The OSF stroke network experience. Stroke 2000; 31: 77-81
    • (2000) Stroke , vol.31 , pp. 77-81
    • Wang, D.Z.1    Rose, J.A.2    Honings, D.S.3    Garwacki, D.J.4    Milbrandt, J.C.5
  • 9
    • 33750578904 scopus 로고    scopus 로고
    • Intravenous Thrombolysis in German Stroke Units before and after Regulatory Approval of Recombinant Tissue Plasminogen Activator
    • Weimar C, Kraywinkel K, Maschke M, Diener HC. Intravenous Thrombolysis in German Stroke Units before and after Regulatory Approval of Recombinant Tissue Plasminogen Activator. Cerebrovasc Dis 2006; 22: 429-431
    • (2006) Cerebrovasc Dis , vol.22 , pp. 429-431
    • Weimar, C.1    Kraywinkel, K.2    Maschke, M.3    Diener, H.C.4
  • 10
    • 0035942340 scopus 로고    scopus 로고
    • Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility
    • Barber PA, Zhang J, Demchuk AM, Hill MD, Buchan AM. Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility. Neurology 2001; 56: 1015-1020
    • (2001) Neurology , vol.56 , pp. 1015-1020
    • Barber, P.A.1    Zhang, J.2    Demchuk, A.M.3    Hill, M.D.4    Buchan, A.M.5
  • 12
    • 0034120507 scopus 로고    scopus 로고
    • Clark WM, Albers GW, Madden KP, Hamilton S. The rtPA (alteplase) 0-to 6-hour acute stroke trial, part A (A0276g) : results of a double-blind, placebo-controlled, multicenter study. Thrombolytic therapy in acute ischemic stroke study investigators. Stroke 2000; 31: 811-816
    • Clark WM, Albers GW, Madden KP, Hamilton S. The rtPA (alteplase) 0-to 6-hour acute stroke trial, part A (A0276g) : results of a double-blind, placebo-controlled, multicenter study. Thrombolytic therapy in acute ischemic stroke study investigators. Stroke 2000; 31: 811-816
  • 13
    • 0033485522 scopus 로고    scopus 로고
    • Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: A randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke
    • Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S. Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. Jama 1999; 282: 2019-2026
    • (1999) Jama , vol.282 , pp. 2019-2026
    • Clark, W.M.1    Wissman, S.2    Albers, G.W.3    Jhamandas, J.H.4    Madden, K.P.5    Hamilton, S.6
  • 14
    • 0032541845 scopus 로고    scopus 로고
    • Kummer R von, Davalos A, Meier D, Larrue V, Bluhmki E, Davis S, Donnan G, Schneider D, Diez-Tejedor E, Trouillas P. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators
    • Hacke W, Kaste M, Fieschi C, Kummer R von, Davalos A, Meier D, Larrue V, Bluhmki E, Davis S, Donnan G, Schneider D, Diez-Tejedor E, Trouillas P. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet 1998; 352: 1245-1251
    • (1998) Lancet , vol.352 , pp. 1245-1251
    • Hacke, W.1    Kaste, M.2    Fieschi, C.3
  • 15
    • 0028892679 scopus 로고
    • Kummer R von, Zoppo GJ del. Treatment of acute ischemic stroke. Challenging the concept of a rigid and universal time window
    • Baron JC, Kummer R von, Zoppo GJ del. Treatment of acute ischemic stroke. Challenging the concept of a rigid and universal time window. Stroke 1995; 26: 2219-2221
    • (1995) Stroke , vol.26 , pp. 2219-2221
    • Baron, J.C.1
  • 16
    • 0036135970 scopus 로고    scopus 로고
    • Thrombolysis in stroke beyond three hours: Targeting patients with diffusion and perfusion MRI
    • Warach S. Thrombolysis in stroke beyond three hours: Targeting patients with diffusion and perfusion MRI. Ann Neurol 2002; 51: 11-13
    • (2002) Ann Neurol , vol.51 , pp. 11-13
    • Warach, S.1
  • 17
    • 0035975584 scopus 로고    scopus 로고
    • CTand MRI in the diagnosis of acute stroke and their role in thrombolysis
    • Rother J. CTand MRI in the diagnosis of acute stroke and their role in thrombolysis. Thromb Res 2001; 103: S125-133
    • (2001) Thromb Res , vol.103
    • Rother, J.1
  • 18
    • 0037320944 scopus 로고    scopus 로고
    • Imaging-based decision making in thrombolytic therapy for ischemic stroke: Present status
    • Schellinger PD, Fiebach JB, Hacke W. Imaging-based decision making in thrombolytic therapy for ischemic stroke: present status. Stroke 2003; 34: 575-583
    • (2003) Stroke , vol.34 , pp. 575-583
    • Schellinger, P.D.1    Fiebach, J.B.2    Hacke, W.3
  • 19
    • 0033486107 scopus 로고    scopus 로고
    • Intra-arterial prouro-kinase for acute ischemic stroke. The PROACT II study: A randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism [see comment]
    • Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark WM, Silver F, Rivera F. Intra-arterial prouro-kinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism [see comment]. Jama 1999; 282: 2003-2011
    • (1999) Jama , vol.282 , pp. 2003-2011
    • Furlan, A.1    Higashida, R.2    Wechsler, L.3    Gent, M.4    Rowley, H.5    Kase, C.6    Pessin, M.7    Ahuja, A.8    Callahan, F.9    Clark, W.M.10    Silver, F.11    Rivera, F.12
  • 20
    • 4744360669 scopus 로고    scopus 로고
    • Influence of pretreatment MRI parameters on clinical outcome, recanalization and infarct size in 49 stroke patients treated by intravenous tissue plasminogen activator
    • Derex L, Nighoghossian N, Hermier M, Adeleine P, Berthezene Y, Philippeau F, Honnorat J, Froment JC, Trouillas P. Influence of pretreatment MRI parameters on clinical outcome, recanalization and infarct size in 49 stroke patients treated by intravenous tissue plasminogen activator. J Neurol Sci 2004; 225: 3-9
    • (2004) J Neurol Sci , vol.225 , pp. 3-9
    • Derex, L.1    Nighoghossian, N.2    Hermier, M.3    Adeleine, P.4    Berthezene, Y.5    Philippeau, F.6    Honnorat, J.7    Froment, J.C.8    Trouillas, P.9
  • 23
    • 14844336929 scopus 로고    scopus 로고
    • Safety and Efficacy of Intravenous Tissue Plasminogen Activator Stroke Treatment in the 3- to 6-Hour Window Using Multimodal Transcranial Doppler/MRI Selection Protocol
    • Ribo M, Molina CA, Rovira A, Quintana M, Delgado P, Montaner J, Grive E, Arenillas JF, Alvarez-Sabin J. Safety and Efficacy of Intravenous Tissue Plasminogen Activator Stroke Treatment in the 3- to 6-Hour Window Using Multimodal Transcranial Doppler/MRI Selection Protocol. Stroke 2005; 36: 602-606
    • (2005) Stroke , vol.36 , pp. 602-606
    • Ribo, M.1    Molina, C.A.2    Rovira, A.3    Quintana, M.4    Delgado, P.5    Montaner, J.6    Grive, E.7    Arenillas, J.F.8    Alvarez-Sabin, J.9
  • 29
    • 19944426190 scopus 로고    scopus 로고
    • Hacke W, Albers G, Al-Rawi Y, Bogousslavsky J, Davalos A, Eliasziw M, Fischer M, Furlan A, Kaste M, Lees KR, Soehngen M, Warach S. The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke 2005; 36: 66-73, Epub 2004 Nov 2029
    • Hacke W, Albers G, Al-Rawi Y, Bogousslavsky J, Davalos A, Eliasziw M, Fischer M, Furlan A, Kaste M, Lees KR, Soehngen M, Warach S. The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke 2005; 36: 66-73, Epub 2004 Nov 2029
  • 31
    • 12844272119 scopus 로고    scopus 로고
    • Hjort N, Butcher K, Davis SM, Kidwell CS, Koroshetz WJ, Rother J, Schellinger PD, Warach S, Ostergaard L. Magnetic resonance imaging criteria for thrombolysis in acute cerebral infarct. Stroke 2005; 36: 388-397, Epub 2004 Dec 2023
    • Hjort N, Butcher K, Davis SM, Kidwell CS, Koroshetz WJ, Rother J, Schellinger PD, Warach S, Ostergaard L. Magnetic resonance imaging criteria for thrombolysis in acute cerebral infarct. Stroke 2005; 36: 388-397, Epub 2004 Dec 2023
  • 32
    • 13944278763 scopus 로고    scopus 로고
    • Selection of thrombolytic therapy beyond 3h using magnetic resonance imaging
    • Davis SM, Donnan GA, Butcher KS, Parsons M. Selection of thrombolytic therapy beyond 3h using magnetic resonance imaging. Curr Opin Neurol 2005; 18: 47-52
    • (2005) Curr Opin Neurol , vol.18 , pp. 47-52
    • Davis, S.M.1    Donnan, G.A.2    Butcher, K.S.3    Parsons, M.4
  • 34
    • 0036327385 scopus 로고    scopus 로고
    • Comparison of admission perfusion computed tomography and qualitative diffusion- and perfusion-weighted magnetic resonance imaging in acute stroke patients
    • Wintermark M, Reichhart M, Cuisenaire O, Maeder P, Thiran JP, Schnyder P, Bogousslavsky J, Meuli R. Comparison of admission perfusion computed tomography and qualitative diffusion- and perfusion-weighted magnetic resonance imaging in acute stroke patients. Stroke 2002; 33: 2025-2031
    • (2002) Stroke , vol.33 , pp. 2025-2031
    • Wintermark, M.1    Reichhart, M.2    Cuisenaire, O.3    Maeder, P.4    Thiran, J.P.5    Schnyder, P.6    Bogousslavsky, J.7    Meuli, R.8
  • 35
    • 0842310813 scopus 로고    scopus 로고
    • Kaste M. Reborn workhorse, CT, pulls the wagon toward thrombolysis beyond 3 hours. Stroke 2004; 35: 357-359
    • Kaste M. Reborn workhorse, CT, pulls the wagon toward thrombolysis beyond 3 hours. Stroke 2004; 35: 357-359
  • 37
    • 0032722337 scopus 로고    scopus 로고
    • Stroke in the very old : Clinical presentation and determinants of 3-month functional outcome: A European perspective. European BIOMED Study of Stroke Care Group
    • Di Carlo A, Lamassa M, Pracucci G, Basile AM, Trefoloni G, Vanni P, Wolfe CD, Tilling K, Ebrahim S, Inzitari D. Stroke in the very old : clinical presentation and determinants of 3-month functional outcome: A European perspective. European BIOMED Study of Stroke Care Group. Stroke 1999; 30: 2313-2319
    • (1999) Stroke , vol.30 , pp. 2313-2319
    • Di Carlo, A.1    Lamassa, M.2    Pracucci, G.3    Basile, A.M.4    Trefoloni, G.5    Vanni, P.6    Wolfe, C.D.7    Tilling, K.8    Ebrahim, S.9    Inzitari, D.10
  • 38
    • 85142981197 scopus 로고    scopus 로고
    • Bamford J, Sandercock P, Dennis M, Burn J, Warlow C. A prospective study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project - 1981 - 86.2. Incidence, case fatality rates and overall outcome at one year of cerebral infarction, primary intracerebral and subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 1990; 53: 16-22
    • Bamford J, Sandercock P, Dennis M, Burn J, Warlow C. A prospective study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project - 1981 - 86.2. Incidence, case fatality rates and overall outcome at one year of cerebral infarction, primary intracerebral and subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 1990; 53: 16-22
  • 40
    • 0343118114 scopus 로고    scopus 로고
    • Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke
    • The NINDS t-PA Stroke Study Group
    • The NINDS t-PA Stroke Study Group. Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. Stroke 1997; 28: 2109-2118
    • (1997) Stroke , vol.28 , pp. 2109-2118
  • 41
    • 0343990052 scopus 로고    scopus 로고
    • Generalized efficacy of t-PA for acute stroke
    • Subgroup analysis of the NINDS t-PA Stroke Trial
    • Subgroup analysis of the NINDS t-PA Stroke Trial. Generalized efficacy of t-PA for acute stroke. Stroke 1997; 28: 2119-2125
    • (1997) Stroke , vol.28 , pp. 2119-2125
  • 42
    • 27644516008 scopus 로고    scopus 로고
    • Outcome and severe hemorrhagic complications of intravenous thrombolysis with tissue plasminogen activator in very old (> or = 80 years) stroke patients
    • Berrouschot J, Rother J, Glahn J, Kucinski T, Fiehler J, Thomalla G. Outcome and severe hemorrhagic complications of intravenous thrombolysis with tissue plasminogen activator in very old (> or = 80 years) stroke patients. Stroke 2005; 36: 2421-2425
    • (2005) Stroke , vol.36 , pp. 2421-2425
    • Berrouschot, J.1    Rother, J.2    Glahn, J.3    Kucinski, T.4    Fiehler, J.5    Thomalla, G.6
  • 46
    • 1542329658 scopus 로고    scopus 로고
    • Is intravenous recombinant tissue plasminogen activator (rt-PA) safe for use in patients over 80 years old with acute ischaemic stroke? - The Calgary experience
    • Simon JE, Sandler DL, Pexman JH, Hill MD, Buchan AM. Is intravenous recombinant tissue plasminogen activator (rt-PA) safe for use in patients over 80 years old with acute ischaemic stroke? - The Calgary experience. Age Ageing 2004; 33: 143-149
    • (2004) Age Ageing , vol.33 , pp. 143-149
    • Simon, J.E.1    Sandler, D.L.2    Pexman, J.H.3    Hill, M.D.4    Buchan, A.M.5
  • 47
    • 33745309395 scopus 로고    scopus 로고
    • Thrombolysis in patients older than 80 years with acute ischaemic stroke: Canadian Alteplase for Stroke Effectiveness Study
    • Sylaja PN, Cote R, Buchan AM, Hill MD. Thrombolysis in patients older than 80 years with acute ischaemic stroke: Canadian Alteplase for Stroke Effectiveness Study. J Neurol Neurosurg Psychiatry 2006; 77: 826-829
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , pp. 826-829
    • Sylaja, P.N.1    Cote, R.2    Buchan, A.M.3    Hill, M.D.4
  • 49
    • 33644551866 scopus 로고    scopus 로고
    • Oostenhrugge RJ van, Hupperts RM, Lodder J. Thrombolysis for acute stroke with special emphasis on the very old: experience from a single Dutch centre. J Neurol Neurosurg Psychiatry 2006; 77: 375-377
    • Oostenhrugge RJ van, Hupperts RM, Lodder J. Thrombolysis for acute stroke with special emphasis on the very old: experience from a single Dutch centre. J Neurol Neurosurg Psychiatry 2006; 77: 375-377
  • 51
    • 0036000314 scopus 로고    scopus 로고
    • Centenarian stroke treated with tissue-type plasminogen activator
    • Gorman MJ, Tanne D, Lewandowski CA. Centenarian stroke treated with tissue-type plasminogen activator. Cerebrovasc Dis 2002; 13: 285-287
    • (2002) Cerebrovasc Dis , vol.13 , pp. 285-287
    • Gorman, M.J.1    Tanne, D.2    Lewandowski, C.A.3
  • 52
    • 0032928437 scopus 로고    scopus 로고
    • Strokes in the elderly - higher acute and 3-month mortality - an explanation
    • Sharma JC, Fletchers, Vassallo M. Strokes in the elderly - higher acute and 3-month mortality - an explanation. Cerebrovasc Dis 1999; 9: 2-9
    • (1999) Cerebrovasc Dis , vol.9 , pp. 2-9
    • Sharma, J.C.1    Fletchers2    Vassallo, M.3
  • 53
    • 0025812589 scopus 로고
    • Older age and elevated blood pressure are risk factors for intracerebral hemorrhage after thrombolysis
    • Anderson JL, Karagounis L, Allen A, Bradford MJ, Menlove RL, Pryor TA. Older age and elevated blood pressure are risk factors for intracerebral hemorrhage after thrombolysis. Am J Cardiol 1991; 68: 166-170
    • (1991) Am J Cardiol , vol.68 , pp. 166-170
    • Anderson, J.L.1    Karagounis, L.2    Allen, A.3    Bradford, M.J.4    Menlove, R.L.5    Pryor, T.A.6
  • 55
    • 34447521224 scopus 로고    scopus 로고
    • The Third International Stroke Trial (Thrombolysis). (1ST-3). http://www.dcn.ed.ac.uk/ist3 [Stand 14.02.2007]
    • The Third International Stroke Trial (Thrombolysis). (1ST-3). http://www.dcn.ed.ac.uk/ist3 [Stand 14.02.2007]
  • 56
    • 34447516495 scopus 로고    scopus 로고
    • Desmoteplase in Acute Ischemic Stroke-2 (DIAS-2) http://paiondias. 01kunden.net/cgi-bin/WebObjects/paionDias.woa/1/wa/DirectoryWithld/1000009.html [Stand 14.02.2007]
    • Desmoteplase in Acute Ischemic Stroke-2 (DIAS-2) http://paiondias. 01kunden.net/cgi-bin/WebObjects/paionDias.woa/1/wa/DirectoryWithld/1000009.html [Stand 14.02.2007]
  • 57
    • 0034870411 scopus 로고    scopus 로고
    • Prerequisites, indications and contraindications of IV-lysis of ischemic stroke with rt-PA]
    • Marx P, Hartmann A, Leistner S, Nohr R, Koennecke HC. [Prerequisites, indications and contraindications of IV-lysis of ischemic stroke with rt-PA]. Fortschr Neurol Psychiatr 2001; 69: 346-352
    • (2001) Fortschr Neurol Psychiatr , vol.69 , pp. 346-352
    • Marx, P.1    Hartmann, A.2    Leistner, S.3    Nohr, R.4    Koennecke, H.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.