Inhibition of erythroid and granulocyte-macrophage colony formation by non-transferrin-bound iron in vitro: Protective effect of apotransferrin

European Journal of Haematology

Volumn 79, Issue 2, 2007, Pages 126-131

  Juvonen, Eeva ^a   Sahlstedt, Leila ^a   Parkkinen, Jaakko ^b   Ruutu, Tapani ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b FINNISH RED CROSS BLOOD SERVICE   (Finland)

Author keywords

Apotransferrin; Erythroid burst forming units; Free iron; Granulocyte macrophage colony forming units; Non transferrin bound iron

Indexed keywords

APOTRANSFERRIN; IRON; NITRILOTRIACETATE IRON; TRANSFERRIN;

ARTICLE; CELL CULTURE; COLONY FORMATION; COLONY FORMING UNIT GM; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; ERYTHROID CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; INCUBATION TIME; IRON BINDING CAPACITY; NORMAL HUMAN; PRIORITY JOURNAL;

APOPROTEINS; CELLS, CULTURED; ERYTHROID CELLS; GRANULOCYTES; HUMANS; IRON; MACROPHAGES; TRANSFERRIN;

EID: 34447345180     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2007.00887.x     Document Type: Article

References (30)

1. Hollan SR. Transfusion-associated iron overload. Curr Opin Hematol 1997 4 : 436 41.
2. Donovan A, Andrews NC. The molecular regulation of iron metabolism. Hematol J 2004 5 : 373 80.
3. McNamara L, MacPhail AP, Mandishona E, Bloom P, Paterson AC, Rouault TA, Gordeuk VR. Non-transferrin-bound iron and hepatic dysfunction in African dietary iron overload. J Gastroenterol Hepatol 1999 14 : 126 32.
4. Giordani A, Haigle J, Leflon P, Risler A, Salmon S, Aubailly M, Maziere JC, Santus R, Morliere P. Contrasting effects of excess ferritin expression on the iron-mediated oxidative stress induced by tert-butyl hydroperoxide or ultraviolet-A in human fibroblasts and keratinocytes. J Photochem Photobiol B 2000 54 : 43 54.
5. Kress GJ, Dineley KE, Reynolds IJ. The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes. J Neurosci 2002 22 : 5848 55.
6. Harrison P, Neilson JR, Marwah SS, Madden L, Bareford D, Milligan DW. Role of non-transferrin bound iron in iron overload and liver dysfunction in long term survivors of acute leukaemia and bone marrow transplantation. J Clin Pathol 1996 49 : 853 6.
7. Bradley SJ, Gosriwitana I, Srichairatanakool S, Hider RC, Porter JB. Non-transferrin-bound iron induced by myeloablative chemotherapy. Br J Haematol 1997 99 : 337 43.
8. Sahlstedt L, Ebeling F, von Bonsdorff L, Parkkinen J, Ruutu T. Non-transferrin-bound iron during allogeneic stem cell transplantation. Br J Haematol 2001 113 : 836 8.
9. Fracanzani AL, Conte D, Fraquelli M, Taioli E, Mattioli M, Losco A, Fargion S. Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease. Hepatology 2001 33 : 647 51.
10. Knekt P, Reunanen A, Takkunen H, Aromaa A, Heliovaara M, Hakulinen T. Body iron stores and risk of cancer. Int J Cancer 1994 56 : 379 82.
11. Franchini M, Veneri D. Iron overload and hematologic malignancies. Hematol J 2004 5 : 381 3.
12. Jensen PD, Heickendorff L, Pedersen B, Bendix-Hansen K, Jensen FT, Christensen T, Boesen AM, Ellegaard J. The effect of iron chelation on haemopoiesis in MDS patients with transfusional iron overload. Br J Haematol 1996 94 : 288 99.
13. von Bonsdorff L, Tölö H, Lindeberg E, Nyman T, Parkkinen J. Development of a pharmaceutical apotransferrin product for iron binding therapy. Biologicals 2001 29 : 27 37.
14. Juvonen E, Ikkala E, Oksanen K, Ruutu T. Megakaryocyte and erythroid colony formation in essential thrombocythaemia and reactive thrombocytosis: diagnostic value and correlation to complications. Br J Haematol 1993 83 : 192 7.
15. Iscove NN, Sieber F, Winterhalter KH. Erythroid colony formation in cultures of mouse and human bone marrow: analysis of the requirement for erythropoietin by gel filtration and affinity chromatography on agarose-concanavalin A. J Cell Physiol 1974 83 : 309 20.
16. Coutinho LH, Will A, Radford J, Schiro R, Testa NG, Dexter TM. Effects of recombinant human granulocyte colony-stimulating factor (CSF), human granulocyte macrophage-CSF, and gibbon interleukin-3 on hematopoiesis in human long-term bone marrow culture. Blood 1990 75 : 2118 29.
17. von Bonsdorff L, Lindeberg E, Sahlstedt L, Lehto J, Parkkinen J. Bleomycin-detectable iron assay for non-transferrin-bound iron in hematologic malignancies. Clin Chem 2002 48 : 307 14.
18. Tavazzi D, Duca L, Graziadei G, Comino A, Fiorelli G, Cappellini MD. Membrane-bound iron contributes to oxidative damage of beta-thalassaemia intermedia erythrocytes. Br J Haematol 2001 112 : 48 50.
19. Dorak MT, Burnett AK, Worwood M. Hemochromatosis gene in leukemia and lymphoma. Leuk Lymphoma 2002 43 : 467 77.
20. Hannuksela J, Savolainen ER, Koistinen P, Parkkila S. Prevalence of HFE genotypes, C282Y and H63D, in patients with hematologic disorders. Haematologica 2002 87 : 131 5.
21. Varkonyi J, Tarkovacs G, Karadi I, Andrikovics H, Varga F, Demeter J, Tordai A. High incidence of hemochromatosis gene mutations in the myelodysplastic syndrome: the Budapest Study on 50 patients. Acta Haematol 2003 109 : 64 67.
22. Gordon LI, Brown SG, Tallman MS, et al. Sequential changes in serum iron and ferritin in patients undergoing high-dose chemotherapy and radiation with autologous bone marrow transplantation: possible implications for treatment related toxicity. Free Radic Biol Med 1995 18 : 383 9.
23. Carmine TC, Evans P, Bruchelt G, Evans R, Handgretinger R, Niethammer D, Halliwell B. Presence of iron catalytic for free radical reactions in patients undergoing chemotherapy: implications for therapeutic management. Cancer Lett 1995 94 : 219 26.
24. Lichtman SM, Attivissimo L, Goldman IS, Schuster MW, Buchbinder A. Secondary hemochromatosis as a long-term complication of the treatment of hematologic malignancies. Am J Hematol 1999 61 : 262 4.
25. Tomas JF, Pinilla I, Garcia-Buey ML, Garcia A, Figuera A, Gomez-Garcia de Soria VGG, Moreno R, Fernandez-Ranada JM. Long-term liver dysfunction after allogeneic bone marrow transplantation: clinical features and course in 61 patients. Bone Marrow Transplant 2000 26 : 649 55.
26. McKay PJ, Murphy JA, Cameron S, Burnett AK, Campbell M, Tansey P, Franklin IM. Iron overload and liver dysfunction after allogeneic or autologous bone marrow transplantation. Bone Marrow Transplant 1996 17 : 63 66.
27. Strasser SI, Kowdley KV, Sale GE, McDonald GB. Iron overload in bone marrow transplant recipients. Bone Marrow Transplant 1998 22 : 167 73.
28. Brandhagen DJ, Alvarez W, Therneau TM, Kruckeberg KE, Thibodeau SN, Ludwig J, Porayko MK. Iron overload in cirrhosis-HFE genotypes and outcome after liver transplantation. Hepatology 2000 31 : 456 60.
29. Altes A, Remacha AF, Sureda A, Martino R, Briones J, Canals C, Brunet S, Sierra J, Gimferrer E. Iron overload might increase transplant-related mortality in haematopoietic stem cell transplantation. Bone Marrow Transplant 2002 29 : 987 9.
30. Sahlstedt L, von Bonsdorff L, Ebeling F, Ruutu T, Parkkinen J. Effective binding of free iron by a single intravenous dose of human apotransferrin in haematological stem cell transplant patients. Br J Haematol 2002 119 : 547 53.