Non-transferrin-bound iron and hepatic dysfunction in African dietary iron overload

Journal of Gastroenterology and Hepatology (Australia)

Volumn 14, Issue 2, 1999, Pages 126-132

  McNamara, Lynne ^a   MacPhail, A Patrick ^a   Mandishona, Eberhard ^a   Bloom, Peter ^a   Paterson, Alan C ^a   Rouault, Tracey A ^c   Gordeuk, Victor R ^b  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^c Department of Medicine George Washington Medicine Center ^*

Author keywords

High performance liquid chromatography; Liver disease; Serum ferritin; Transferrin saturation

Indexed keywords

FERRITIN; IRON; TRANSFERRIN;

ADULT; AFRICA; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IRON INTAKE; IRON OVERLOAD; LIVER BIOPSY; LIVER DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0032940347     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.1999.01830.x     Document Type: Article

References (25)

1. 1 Batey RG, Lai Chung Fong P, Shmir S, Sherlock S. A non-transferrin-bound serum iron in idiopathic haemochromatosis. Dig. Dis. Sci. 1980; 25: 340-6.
2. 2 Grootveldt M, Bell JD, Halliwell B, Aruoma OI, Bomford A, Sadler PJ. Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis. J. Biol. Chem. 1989; 264: 4417-22.
3. 3 Hershko C, Graham G, Bates TW, Rachmilewitz EA. Non-specific serum iron in thalassaemia: An abnormal serum iron fraction of potential toxicity. Br. J. Haematol. 1978; 40: 255-63.
4. 4 Anuwatanakulchai M, Pootrakul P, Thuvassethakul P, Wasi P. Non-transferrin plasma iron in beta-thalassaemia/hb E and haemoglobin H diseases. Scand. J. Haematol. 1984; 32: 153-8.
5. 5 Wang WC, Ahmed N, Hanna M. Non-transferrin-bound iron in long-term transfusion in children with congenital anemias. J. Pediatr. 1986; 108: 552-7.
6. 6 Gutteridge JMC, Rowley DA, Griffiths E, Halliwell B. Low-molecular-weight iron complexes and oxygen radical reactions in idiopathic haemochromatosis. Clin. Sci. 1985; 68: 463-7.
7. 7 Gordeuk VR, Boyd RD, Brittenham GM. Dietary iron overload persists in rural sub-Saharan Africa. Lancet 1986; i: 1310-13.
8. 8 Bothwell TH, Seftel H, Jacobs P, Torrance JD, Baumslag N. Iron overload in Bantu subjects. Studies on the availability of iron in Bantu beer. Am. J. Clin. Nutr. 1964; 14: 47-51.
9. 9 Bothwell TH, Charlton RW, Seftel HC. Oral iron overload. S. Afr. Med. J. 1965; 9: 892-900.
10. 10 Isaacson C, Seftel H, Keeley KJ, Bothwell TH. The relationship between iron overload and cirrhosis. J. Lab. Clin. Med. 1961; 58: 845-53.
11. 11 Gordeuk V, Mukiibi J, Hasstedt SJ et al. Iron overload in Africa. Interaction between a gene and dietary iron content. N. Engl. J. Med. 1992; 326: 95-100.
12. 12 Scheuer PJ, Williams R, Muir AR. Hepatic pathology in relatives of patients with haemochromatosis. J. Pathol. 1962; 84: 53-64.
13. 13 Conradie JD, Mbhele BEL. Quantitation of serum ferritin by an enzyme-linked immunosorbent assay, ELISA. S. Afr. Med. J. 1980; 57: 282-7.
14. 14 International Committee for Standardisation in Haematology (Iron Panel). The measurement of total and unsaturated iron binding capacity in serum. Br. J. Haematol. 1978; 38: 281-90.
15. 15 International Committee for Standardisation in Haematology (Iron Panel). Recommendations for measurements of serum iron in human blood. Br. J. Haematol. 1978; 38: 291-4.
16. 16 Singh S, Hider RC, Porter JB. A direct method for quantification of non-transferrin-bound iron. Anal. Biochem. 1990; 186: 320-3.
17. 17 Pape L, Multari JS, Stitt C, Saltman P. The mobilization of iron from ferritin by chelating agents. Biochemistry 1968; 7: 613-16.
18. 1. Br. J. Haematol. 1992; 82: 431-6.
19. 19 Porter JB, Abeysinghe RD, Marshall L, Hider RC, Singh S. Kinetics of removal and re-appearance of non-transferrin-bound plasma iron with desferrioxamine therapy. Blood 1996; 88: 705-13.
20. 20 Baker E, Morgan EH. Iron transport. In: Brock J, Halliday J, Pippard M, Powell L, eds. Iron Metabolism in Health and Disease. London: WB Saunders Co., 1994; 66-95.
21. 21 Brissot P, Wright TL, Ma W-L, Weisiger RA. Efficient clearance of non-transferrin-bound iron by rat liver. J. Clin. Invest. 1985; 76: 1463-70.
22. 22 Link G, Pinson A, Hershko C. Heart cells in culture: A model of myocardial iron overload and chelation. J. Lab. Clin. Med. 1985; 106: 147-53.
23. 23 Britton RS, Tavill AS, Bacon BR. Mechanisms of iron toxicity. In: Brock J, Halliday J, Pippard M, Powell L, eds. Iron Metabolism in Health and Disease. London: WB Saunders Co., 1994; 311-51.
24. 24 Dürken M, Nielsen P, Knobel S et al. Non-transferrin-bound iron in serum of patients receiving bone marrow transplants. Free Rad. Biol. Med. 1997; 22: 1159-63.
25. 25 Lipschitzs DA, Cook JD, Finch CA. A clinical evaluation of serum ferritin. N. Engl. J. Med. 1974; 290: 1213-16.