Dexamethasone treatment differentially affects the oxidative energy metabolism of rat brain mitochondria in developing and adult animals

International Journal of Developmental Neuroscience

Volumn 25, Issue 5, 2007, Pages 309-316

  Pandya, Jignesh D ^a   Agarwal, Neeraj A ^a   Katyare, Surendra S ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

ATPase activity; Brain development; Brain mitochondria; Cytochrome content; Dehydrogenases activities; Dexamethasone; Glucocorticoids; Oxidative phosphorylation

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ASCORBIC ACID; DEXAMETHASONE; GLUTAMIC ACID; MALIC ACID; N,N,N',N' TETRAMETHYL 1,4 PHENYLENEDIAMINE; OXIDOREDUCTASE; PYRUVIC ACID; SUCCINIC ACID;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ARTICLE; BIOENERGY; BRAIN DEVELOPMENT; BRAIN METABOLISM; BRAIN MITOCHONDRION; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DRUG EFFECT; ENERGY METABOLISM; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BRAIN; BRAIN CHEMISTRY; CYTOCHROMES; DEXAMETHASONE; ENERGY METABOLISM; MALE; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE PHOSPHORYLATION; OXIDOREDUCTASES; RATS;

ANIMALIA; RATTUS;

EID: 34447330699     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2007.05.001     Document Type: Article

References (47)

1. Ahlersova E., Ahlers I., and Smajda B. Influence of light regimen and time of year on circadian oscillations of insulin and corticosterone in rats. Physiol. Res. 41 (1992) 307-314
2. Barrington K.J. The adverse neuro-developmental effects of postnatal steroids in the pre-term infant: a systematic review of RCTs. BMC Pediatr. 1 (2001) 1
3. Bauer B.R.N., Hartz A.M.S., Fricker G., and Miller D.S. Modulation of p-glycoprotein transport function at the blood-brain barrier. Exp. Biol. Med. 230 (2005) 118-127
4. Brocklehurst P., Gates S., McKenzie-McHarg K., Alfirevic Z., and Chamberlain G. Are we prescribing multiple courses of ante-natal corticosteroids? A survey of practice in the UK. Br. J. Obstet. Gynaecol. 106 (1999) 977-979
5. Demonacos C.V., Karayanni N., Hatzoglou E., Tsiriyiotis C., Spandidos D.A., and Sekeris C.E. Mitochondrial genes as sites of primary action of steroid hormones. Steroids 61 (1996) 226-232
6. Doyle L., and Davis P. Postnatal corticosteroids in pre-term infants: systematic review of effects on mortality and motor function. J. Paediatr. Child. Health 36 (2000) 101-107
7. Duval D., Durant S., and Homo-Delarchi F. Non genomic effects of steroids: interactions of steroid molecules with membrane structures and functions. Biochim. Biophys. Acta 737 (1983) 409-442
8. Erecinska M., Cherian S., and Silver I.A. Energy metabolism in mammalian brain during development. Prog. Neurobiol. 73 (2004) 397-445
9. Ferguson S.A., and Holson R.R. Neonatal dexamethasone on day 7 causes mild hyperactivity and cerebellar stunting. Neurotoxicol. Teratol. 21 (1999) 71-76
10. Ferreira J., and Gil L. Nutritional effects on mitochondrial bioenergetics alterations in oxidative phosphorylation by rat liver mitochondria. Biochem. J. 218 (1984) 61-67
11. Fiske C.H., and SubbaRow Y. Colorimetric determination of phosphorus. J. Biol. Chem. 66 (1925) 375-400
12. Flagel S.B., Vazquez D.M., Watson Jr. S.J., and Neal Jr. C.R. Effects of tapering neonatal dexamethasone on rat growth, neurodevelopment, and stress response. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282 (2002) R55-R63
13. Gerrard G.E., and Franks K.N. Overview of the diagnosis and management of brain, spine, and meningeal metastases. J. Neurol. Neurosurg. Psychiatry 75 Suppl. 2 (2004) ii37-ii42
14. Hagberg H., and Jacobsson B. Brain injury in pre-term infants-what can the obstetrician do?. Early Hum. Dev. 81 (2005) 231-235
15. Jani M.S., Telang S.D., and Katyare S.S. Effect of corticosterone treatment on energy metabolism in rat liver mitochondria. J. Steroid Biochem. Mol. Biol. 38 (1991) 587-591
16. Jobe A.H., and Soll R.F. Choice and dose of corticosteroid for ante-natal treatments. Am. J. Obstet. Gynecol. 190 (2004) 878-881
17. Katyare S.S., Joshi M.V., Fatterpaker P., and Sreenivasan A. Effect of thyroid deficiency on oxidative phosphorylation in rat liver, kidney, and brain mitochondria. Arch. Biochem. Biophys. 182 (1977) 155-163
18. Katyare S.S., and Rajan R.R. Enhanced oxidative phosphorylation in rat liver mitochondria following prolonged in vivo treatment with imipramine. Br. J. Pharmacol. 95 (1988) 914-922
19. Katyare S.S., Bangur C.S., and Howland J.L. Is respiratory activity in the brain mitochondria responsive to thyroid hormone action? A critical re-evaluation. Biochem. J. 302 (1994) 857-860
20. Katyare S.S., Balasubramanian S., and Parmar D.V. Effect of corticosterone treatment on mitochondrial oxidative energy metabolism in developing rat brain. Exp. Neurol. 183 (2003) 241-248
21. Kumar P. Effect of decreased use of postnatal corticosteroids on morbidity in extremely low birth weight infants. Am. J. Perinatol. 22 (2005) 77-81
22. Leighton F., Poole B., Beaufay H., Baudhuin P., Coffey J.W., Fowler S., and De Duve C. The large scale separation of peroxisomes, mitochondria and lysosomes from livers of rats injected with Triton X-100: improved isolation procedures, analysis and biochemical properties of fractions. J. Cell. Biol. 37 (1968) 482-513
23. Leung T.N., Lam P.M., Ng P.C., and Lau T.K. Repeated courses of ante-natal corticosteroids: is it justified?. Acta Obstet. Gynecol. Scand. 82 (2003) 589-596
24. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin Phenol reagent. J. Biol. Chem. 193 (1951) 265-275
25. Neal, Weidemann G., Kabbaj M., and Vazquez D.M. Effect of neonatal dexamethasone exposure on growth and neurological development in the adult rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 (2004) R375-R385
26. Ochoa S. Malic dehydrogenase from pig heart. In: Colowick S.P., and Kaplan N.O. (Eds). Methods Enzymology (1995), Academic Press, New York 735-739
27. Pandya, J.D., 2002. Thesis entitled "biochemical investigations on dexamethasone-induced changes in rat brain metabolism", Department of Biochemistry, Faculty of Science, M.S. University of Baroda, Vadodara, India.
28. Pandya J.D., Agarwal N.A., and Katyare S.S. Effect of dexamethasone treatment on oxidative energy metabolism in rat liver mitochondria during postnatal developmental periods. Drug Chem. Toxicol. 27 (2004) 389-403
29. Patel S.P., and Katyare S.S. Differences in kinetic properties of cytochrome oxidase in mitochondria from rat tissues. A comparative study. Z. Naturforsch. [C] 60 (2005) 785-791
30. Poyton R.O., and McEwen J.E. Crosstalk between nuclear and mitochondrial genomes. Annu. Rev. Biochem. 65 (1996) 563-607
31. Rastogi A., Akintorin S.M., Bez M.L., Morales P., and Pildes R.S. A controlled trial of dexamethasone to prevent bronchopulmonary dysplasia in surfactant-treated infants. Pediatrics 98 (1996) 204-210
32. Regina A., Romero I.A., Greenwood J., Adamson P., Bourre J.-M., Couraud P.-O., and Roux F. Dexamethasone regulation of p-glycoprotein activity in an immortalized rat brain endothelial cell line. GPNT J. Neurochem. 73 (1999) 1954-1963
33. Reul J.M., van den Bosch .F.R., and de Kloet E.R. Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: functional implications. J. Endocrinol. 115 (1987) 459-467
34. Reul J.M., Pearce P.T., Funder J.W., and Krozowski Z.S. Type I and type II corticosteroid receptor gene expression in the rat: effect of adrenalectomy and dexamethasone administration. Mol. Endocrinol. 3 (1989) 1674-1680
35. Reul J.M., Gesing A., Droste S., Stec I.S., Weber A., Bachmann C., Bilang-Bleuel A., Holsboer F., and Linthorst A.C. The brain mineralocorticoid receptor: greedy for ligand, mysterious in function. Eur. J. Pharmacol. 405 (2000) 235-249
36. Romagnoli C., Zecca E., Vento G., Maggio L., Papacci P., and Tortorolo G. Effect on growth of two different dexamethasone courses for pre-term infants at risk of chronic lung disease. A randomized trial. Pharmacology 59 (1999) 266-274
37. Roussel D., Dumas J.F., Simard G., Malthiery Y., and Ritz P. Kinetics and control of oxidative phosphorylation in rat liver mitochondria after dexamethasone treatment. Biochem. J. 382 (2004) 491-499
38. Sapolsky R.M., and Meaney M.J. Maturation of the adrenocortical stress response: neuroendocrine control mechanisms and the stress hyporesponsive period. Brain Res. 396 (1986) 64-76
39. Satav J.G., and Katyare S.S. Effect of experimental thyrotoxicosis on oxidative phosphorylation in rat liver, kidney and brain mitochondria. Mol. Cell. Endocrinol. 28 (1982) 173-189
40. Schimmer B.P., and Parker K.L. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In: Gilman A.G., Hardman J.G., and Limbird L.E. (Eds). The Pharmacological Basis of Therapeutics (2001), McGraw-Hill Companies 1635-1648
41. Simon N., Jolliet P., Morin C., Zini R., Urien S., and Tillement J.P. Glucocorticoids decrease cytochrome c oxidase activity of isolated rat kidney mitochondria. FEBS Lett. 435 (1998) 25-28
42. Subramanian M., and Katyare S.S. Oxidative phosphorylation in mouse liver mitochondria during weaning. Mech. Ageing Dev. 54 (1990) 121-129
43. Swegert C.V., Dave K.R., and Katyare S.S. Effect of aluminium-induced Alzheimer like condition on oxidative energy metabolism in rat liver, brain and heart mitochondria. Mech. Ageing Dev. 112 (1999) 27-42
44. Tsiriyotis C., Spandidos D.A., and Sekeris C.E. The mitochondrion as a primary site of action of glucocorticoids: mitochondrial nucleotide sequences, showing similarity to hormone response elements, confer dexamethasone inducibility to chimaeric genes transfected in LATK-cells. Biochem. Biophys. Res. Commun. 235 (1997) 349-354
45. Tsuneishi S., Takada S., Motoike T., Ohashi T., Sano K., and Nakamura H. Effects of dexamethasone on the expression of myelin basic protein, proteolipid protein, and glial fibrillary acidic protein genes in developing rat brain. Brain Res. Dev. Brain Res. 61 (1991) 117-123
46. Wapner R. Ante-natal corticosteroids: we continue to learn. Am. J. Obstet. Gynecol. 190 (2004) 875
47. Whitelaw A., and Thoresen M. Ante-natal steroids and the developing brain. Arch. Dis. Child. Fetal Neonatal Ed. 83 (2000) F154-F157