Dosage suppression of the Kluyveromyces lactis zymocin by Saccharomyces cerevisiae ISR1 and UGP1

FEMS Yeast Research

Volumn 7, Issue 5, 2007, Pages 722-730

  Mehlgarten, Constance ^b   Zink, Sabrina ^a,b   Rutter, Jared ^c   Schaffrath, Raffael ^b  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

ISR1; Kluyveromyces lactis killer yeast; PHO85; UGP1; Zymocin toxin

Indexed keywords

CYCLIN DEPENDENT KINASE; ENZYME; FUNGAL PROTEIN; GALANIN; PKC1 RELATED KINASE; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE GLUCOSE 1 PHOSPHATE URIDYLYLTRANSFERASE; ZYMOCIN;

ANALYTIC METHOD; CELL WALL; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; KLUYVEROMYCES; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; WESTERN BLOTTING;

ANTIFUNGAL AGENTS; CYCLINS; GENE EXPRESSION REGULATION, FUNGAL; KLUYVEROMYCES; MYCOTOXINS; PROTEIN KINASE C; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; UTP-GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE;

KLUYVEROMYCES LACTIS; SACCHAROMYCES CEREVISIAE;

EID: 34447328787     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2007.00216.x     Document Type: Conference Paper

References (41)

1. Butler AR, O'Donnell RW, Martin VJ, Gooday GW Stark MJ (1991) Kluyveromyces lactis toxin has an essential chitinase activity. Eur J Biochem 199 : 483 488.
2. Butler AR, White JH, Folawiyo Y, Edlin A, Gardiner D Stark MJ (1994) Two Saccharomyces cerevisiae genes which control sensitivity to G1 arrest induced by Kluyveromyces lactis toxin. Mol Cell Biol 14 : 6306 6316.
3. Carroll AS, Bishop AC, DeRisi JL, Shokat KM O'Shea EK (2001) Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response. Proc Natl Acad Sci USA 98 : 12578 12583.
4. Crouzet M Tuite MF (1987) Genetic control of translational fidelity in yeast: molecular cloning and analysis of the allosuppressor gene SAL3. Mol Gen Genet 210 : 581 583.
5. Daran JM, Dallies N, Thines-Sempoux D, Paquet V Francois J (1995) Genetic and biochemical characterization of the UGP1 gene encoding the UDP-glucose pyrophosphorylase from Saccharomyces cerevisiae. Eur J Biochem 233 : 520 530.
6. Daran JM, Bell W Francois J (1997) Physiological and morphological effects of genetic alterations leading to a reduced synthesis of UDP-glucose in Saccharomyces cerevisiae. FEMS Microbiol Lett 153 : 89 96.
7. Dephoure N, Howson RW, Blethrow JD, Shokat KM O'Shea EK (2005) Combining chemical genetics and proteomics to identify protein kinase substrates. Proc Natl Acad Sci USA 102 : 17940 17945.
8. Fichtner L, Frohloff F, Bürkner K, Larsen M, Breunig KD Schaffrath R (2002) Molecular analysis of KTI12/TOT4, a Saccharomyces cerevisiae gene required for Kluyveromyces lactis zymocin action. Mol Microbiol 43 : 783 791.
9. Flores-Diaz M, Alape-Giron A, Persson B, Pollesello P, Moos M, von Eichel-Streiber C, Thelestam M Florin I (1997) Cellular UDP-glucose deficiency caused by a single point mutation in the UDP-glucose pyrophosphorylase gene. J Biol Chem 272 : 23784 23791.
10. Frohloff F, Fichtner L, Jablonowski D, Breunig KD Schaffrath R (2001) Saccharomyces cerevisiae Elongator mutations confer resistance to the Kluyveromyces lactis zymocin. EMBO J 20 : 1993 2003.
11. Gietz D, St Jean A, Woods RA Schiestl RH (1992) Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res 20 : 1425.
12. Hardy TA Roach PJ (1993) Control of yeast glycogen synthase-2 by COOH-terminal phosphorylation. J Biol Chem 268 : 23799 23805.
13. Huang D, Moffat J Andrews B (2002) Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity. Mol Cell Biol 22 : 5076 5088.
14. Huang B, Johanson MJ Bystrom AS (2005) An early step in wobble uridine tRNA modification requires the Elongator complex. RNA 11 : 424 436.
15. Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS O'Shea EK (2003) Global analysis of protein localization in budding yeast. Nature 425 : 686 691.
16. Jablonowski D, Butler AR, Fichtner L, Gardiner D, Schaffrath R Stark MJ (2001a) Sit4p protein phosphatase is required for sensitivity of Saccharomyces cerevisiae to Kluyveromyces lactis zymocin. Genetics 159 : 1479 1489.
17. Jablonowski D, Fichtner L, Martin VJ, Klassen R, Meinhardt F, Stark MJ Schaffrath R (2001b) Saccharomyces cerevisiae cell wall chitin, the Kluyveromyces lactis zymocin receptor. Yeast 18 : 1285 1299.
18. Jablonowski D, Fichtner L, Frohloff F Schaffrath R (2003) Chitin binding capability of the zymocin complex from Kluyveromyces lactis. Non-Conventional Yeasts in Genetics, Biochemistry and Biotechnology (Wolf K, Breunig KD Barth G, eds), pp. 191 194. Springer-Verlag, Berlin.
19. Jablonowski D, Zink S, Mehlgarten C, Daum G Schaffrath R (2006) tRNAGlu wobble uridine methylation by Trm9 identifies Elongator's key role for zymocin-induced cell death in yeast. Mol Microbiol 59 : 677 688.
20. Kalhor HR Clarke S (2003) Novel methyltransferase for modified uridine residues at the wobble position of tRNA. Mol Cell Biol 23 : 9283 9292.
21. Kaufmann G (2000) Anticodon nucleases. Trends Biochem Sci 25 : 70 74.
22. Kishida M, Tokunaga M, Katayose Y, Yajima H, Kawamura-Watabe A Hishinuma F (1996) Isolation and genetic characterization of pGKL killer-insensitive mutants (iki) from Saccharomyces cerevisiae. Biosci Biotechnol Biochem 60 : 798 801.
23. Lenburg ME O'Shea EK (2001) Genetic evidence for a morphogenetic function of the Saccharomyces cerevisiae Pho85 cyclin-dependent kinase. Genetics 157 : 39 51.
24. Lesage G Bussey H (2006) Cell wall assembly in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 70 : 317 343.
25. Levin DE (2005) Cell wall integrity signalling in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 69 : 262 291.
26. Lu J, Huang B, Esberg A, Johansson MJ Bystrom AS (2005) The Kluyveromyces lactis gamma-toxin targets tRNA anticodons. RNA 11 : 1648 1654.
27. Measday V, Moore L, Retnakaran R, Lee J, Donoviel M, Neiman AM Andrews B (1997) A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase. Mol Cell Biol 17 : 1212 1223.
28. Mehlgarten C Schaffrath R (2004) After chitin-docking, toxicity of Kluyveromyces lactis zymocin requires Saccharomyces cerevisiae plasma membrane H+-ATPase. Cell Microbiol 6 : 569 580.
29. Miyahara K, Hirata D Miyakawa T (1998) Functional interaction of Isr1, a predicted protein kinase, with the Pkc1 pathway in Saccharomyces cerevisiae. Biosci Biotechnol Biochem 62 : 1376 1380.
30. Moffat J Andrews B (2004) Late-G1 cyclin-CDK activity is essential for control of cell morphogenesis in budding yeast. Nat Cell Biol 6 : 59 66.
31. Nishizawa M, Tanabe M, Yabuki N, Kitada K Toh-e A (2001) Pho85 kinase, a yeast cyclin-dependent kinase, regulates the expression of UGP1 encoding UDP-glucose pyrophosphorylase. Yeast 18 : 239 249.
32. Otero G, Fellows J, Li Y, de Bizemont T, Dirac AM, Gustafsson CM, Erdjument-Bromage H, Tempst P Svejstrup JQ (1999) Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell 3 : 109 118.
33. Rahl PB, Chen CZ Collins RN (2005) Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation. Mol Cell 17 : 841 853.
34. Rutter J, Probst BL McKnight SL (2002) Coordinate regulation of sugar flux and translation by PAS kinase. Cell 111 : 17 28.
35. Schaffrath R Breunig KD (2000) Genetics and molecular physiology of the yeast Kluyveromyces lactis. Fungal Genet Biol 30 : 173 190.
36. Schaffrath R Meinhardt F (2005) Kluyveromyces lactis zymocin and other plasmid-encoded yeast killer toxins. Topics in Current Genetics, Microbial Protein Toxins, Vol. 11 (Schmitt M Schaffrath R, eds), pp. 133 155. Springer-Verlag, Berlin.
37. Sherman F (1991) Getting started with yeast. Meth Enzymol 194 : 3 21.
38. Sikorski RS Hieter P (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122 : 19 27.
39. Stark MJ, Boyd A, Mileham AJ Romanos MA (1990) The plasmid-encoded killer system of Kluyveromyces lactis: a review. Yeast 6 : 1 29.
40. Tokunaga M, Wada N Hishinuma F (1989) Expression of pGKL killer 28K subunit in Saccharomyces cerevisae: identification of 28K subunit as a killer protein. Nucleic Acids Res 17 : 3435 3446.
41. Zink S, Mehlgarten C, Kitamoto HK, Nagase J, Jablonowski D, Dickson RC, Stark MJ Schaffrath R (2005) M(IP)2C, the major yeast plasma membrane sphingolipid, governs toxicity of Kluyveromyces lactis zymocin. Eukaryot Cell 4 : 879 889.