Loss of epithelium cadherin expression is associated with reduced overall survival and disease-free survival in early-stage squamous cell cervical carcinoma

International Journal of Gynecological Cancer

Volumn 17, Issue 4, 2007, Pages 843-850

  Dursun, P ^a   Yuce, K ^a   Usubutun, A ^a   Ayhan, A ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Adhesion molecules; E cadherin; Recurrence; Survival; Uterine cervical carcinoma

Indexed keywords

UVOMORULIN;

ADULT; ARTICLE; CANCER RECURRENCE; CANCER SURVIVAL; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; LYMPH NODE METASTASIS; LYMPH VESSEL; MAJOR CLINICAL STUDY; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; STATISTICAL SIGNIFICANCE; STROMA; UTERINE CERVIX CARCINOMA;

ADULT; AGED; CADHERINS; CARCINOMA, SQUAMOUS CELL; CELL ADHESION; DISEASE-FREE SURVIVAL; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEOPLASM STAGING; UTERINE CERVICAL NEOPLASMS;

EID: 34447321623     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1111/j.1525-1438.2007.00876.x     Document Type: Article

References (46)

1. Ordonez NG. Value of E-cadherin and N-cadherin immunostaining in the diagnosis of mesothelioma. Hum Pathol 2003 34: 749 55.
2. Nollet F, Kools P, van Roy F. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. J Mol Biol 2000 299: 551 72.
3. Takeichi M. Cadherin cell adhesion receptors as morphogenetic regulators. Science 1991 251: 1451 5.
4. Birchmeier W, Behrens J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1994 1198: 11 26.
5. Hirohashi S. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol 1998 153: 333 9.
6. Shiozaki H, Oka H, Inoue M et al. E-cadherin mediated adhesion system in cancer cells. Cancer 1996 77: 1605 13.
7. Bankfalvi A, Krassort M, Buchwalow IB, Vegh A, Felszeghy E, Piffko J. Gains and losses of adhesion molecules (CD44, E-cadherin, beta-catenin) during oral carcinogenesis and tumour progression. J Pathol 2002 198: 343 51.
8. Huiping C, Kristjansdottir S, Jonasson JG, Magnusson J, Egilsson V, Ingvarsson S. Alterations of E-cadherin and beta-catenin in gastric cancer. BMC Cancer 2001 1: 16 25.
9. Krishnadath KK, Tilanus HW, van Blankenstein M et al. Reduced expression of the cadherin-catenin complex in oesophageal adenocarcinoma correlates with poor prognosis. J Pathol 1997 182: 331 8.
10. Shimazui T, Schalken JA, Giroldi LA et al. Prognostic value of cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120cas) in bladder tumors. Cancer Res 1996 56: 4154 8.
11. Kase S, Sugio K, Yamazaki K, Okamoto T, Yano T, Sugimachi K. Expression of E-cadherin and beta-catenin in human non-small cell lung cancer and the clinical significance. Clin Cancer Res 2000 6: 4789 96.
12. Yoshida R, Kimura N, Harada Y et al. The loss of E-cadherin, alpha- and beta-catenin expression is associated with metastasis and poor prognosis in invasive breast cancer. Int J Oncol 2001 18: 513 20.
13. Van de Putte G, Kristensen GB, Baekelandt M, Lie AK, Holm R. E-cadherin and catenins in early squamous cervical carcinoma. Gynecol Oncol 2004 94: 521 7.
14. Wilding J, Vousden KH, Soutter WP, Mac Crea PD, Del Buono R, Pignatelli M. E-cadherin transfection down-regulates the epidermal growth factor receptor and reverses the invasive phenotype of human papilloma virus-transfected keratinocytes. Cancer Res 1996 56: 5285 92.
15. Moon HS, Park WI, Choi EA, Chung HW, Kim SC. The expression and thyrosine phosphorylation of E-cadherin/catenin adhesion complex, and focal adhesion kinase in invasive cervical carcinomas. Int J Gynecol Cancer 2003 13: 640 6.
16. Chen CL, Liu SS, Ip SM, Wong LC, Ng TY, Ngan HY. E-cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours. Eur J Cancer 2003 39: 517 23.
17. Chen HC, Chu RY, Hsu PN et al. Loss of E-cadherin expression correlates with poor differentiation and invasion into adjacent organs in gastric adenocarcinomas. Cancer Lett 2003 201: 97 106.
18. Edelman GM, Crossin KL. Cell adhesion molecules: implications for a molecular histology. Annu Rev Biochem 1991 60: 155 90.
19. Behrens J, Mareel MM, Van Roy FM, Birchmeier W. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol 1989 108: 2435 47.
20. Faleiro-Rodrigues C, Macedo-Pinto I, Pereira D, Ferreira VM, Lopes CS. Association of E-cadherin and beta-catenin immunoexpression with clinicopathologic features in primary ovarian carcinomas. Hum Pathol 2004 35: 663 9.
21. Darai E, Walker-Combrouze F, Benifla JL et al. E-Cadherin and CD44 expression in cervical intraepithelial neoplasia: comparison between HIV-positive and HIV-negative women and correlation with HPV status. Gynecol Oncol 2000 76: 56 62.
22. Chen W, Obrink B. Cell-cell contacts mediated by E-cadherin restrict invasive behavior of L-cells. J Cell Biol 1991 114: 319 27.
23. Frixen UH, Behrens J, Sachs M et al. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 1991 113: 173 85.
24. Takeichi M. Cadherins in cancer: implications for invasion and metastasis. Curr Opin Cell Biol 1993 5: 806 11.
25. Bracke ME, Van Roy FM, Mareel MM. The E-cadherin/catenin complex in invasion and metastases. Curr Top Microbiol Immunol 1996 213: 124 61.
26. Vleminckx K, Vakaet L Jr., Mareel M, Fiers W, van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991 66: 107 19.
27. Bankfalvi A, Terpe HJ, Breukelmann D et al. Immunophenotypic and prognostic analysis of E-cadherin and beta-catenin expression during breast carcinogenesis and tumour progression: a comparative study with CD44. Histopathology 1999 34: 25 34.
28. Chow V, Yuen AP, Lam KY, Tsao GS, Ho WK, Wei WI. A comparative study of the clinicopathological significance of E-cadherin and catenins (alpha, beta, gamma) expression in the surgical management of oral tongue carcinoma. J Cancer Res Clin Oncol 2001 127: 59 63.
29. Bohm J, Niskanen L, Kiraly K et al. Expression and prognostic value of alpha-, beta-, and gamma-catenins indifferentiated thyroid carcinoma. J Clin Endocrinol Metab 2000 85: 4806 11.
30. Darai E, Scoazec J-Y, Walker-Combrouze F et al. Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors. Hum Pathol 1997 28: 922 8.
31. Davies BR, Worsley SD, Ponder BAJ. Expression of E-cadherin, α- and β-catenin in normal ovarian surface epithelium and epithelial ovarian cancers. Histopathology 1998 32: 69 80.
32. Jiang WG, Mansel RE. E-cadherin complex and its abnormalities in human breast cancer. Surg Oncol 2000 9: 151 71.
33. Jeffers MD, Paxton J, Bolger B, Richmond JA, Kennedy JH, McNicole AM. E-cadherin and integrin cell adhesion molecule expression in invasive and in situ carcinoma of the cervix. Gynecol Oncol 1997 64: 481 6.
34. Carico E, Atlante M, Bucci B, Nofroni I, Vecchione A. E-cadherin and a-catenin expression during tumor progression of cervical carcinoma. Gynecol Oncol 2001 80: 156 61.
35. Choi YS, Shim YM, Kim SH et al. Prognostic significance of E-cadherin and b-catenin in resected stage I non-small cell lung cancer. Eur J Cardiothorac Surg 2003 24: 441 9.
36. Kawano T, Nakamura Y, Yanoma S et al. Expression of E-cadherin, and CD44s and CD44v6 and its association with prognosis in head and neck cancer. Auris Nasus Larynx 2004 31: 35 41.
37. Yaldizi M, Hakverdi AU, Bayhan G, Akkus Z. Expression of E-cadherin in squamous cell carcinomas of the cervix with correlations to clinicopathological features. Eur J Gynaecol Oncol 2005 26: 95 8.
38. Sakuragi et al. Decreased E-cad expression in endometrial carcinoma is associated with tumor dedifferentiation and deep myometrial invasion. Gynecol Oncol 1994.
39. Rodrigo JP, Dominguez F, Alvarez C, Herrero A, Suarez C. Expression of E-cadherin, CD44s, and CD44v6 in laryngeal and pharyngeal carcinomas. Am J Otolaryngol 2003 24: 384 9.
40. Han AC, Edelson MI, Peralta Soler A et al. Cadherin expression in glandular tumors of the cervix. Aberrant P-cadherin expression as a possible marker of malignancy. Cancer 2000 89: 2053 8.
41. Rodriguez-Sastre MA, Gonzalez-Maya L, Delgado R et al. Abnormal distribution of E-cadherin and beta-catenin in different histologic types of cancer of uterine cervix. Gynecol Oncol 2005 97: 330 6.
42. Wu H, Lotan R, Menter D, Lippman SM, Xu XC. Expression of E-cadherin is associated with squamous differentiation in squamous cell carcinomas. Anticancer Res 2000 20: 1385 90.
43. Brecelj E, Frkovic Grazio S, Auersperg M, Bracko M. Prognostic value of E-cadherin expression in thyroid follicular carcinoma. Eur J Surg Oncol 2005 31: 544 8.
44. Richmond PJ, Karayiannakis AJ, Nagafuchi A et al. Aberrant E-cadherin and alpha-catenin expression in prostate cancer: correlation with patient survival. Cancer Res 1997 57: 3189 93.
45. Chang HW, Chow V, Lam KY, Wei WI, Yuen A. Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance. Cancer 2002 94: 386 92.
46. Ferreira P, Oliveira MJ, Beraldi E et al. Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro. Exp Cell Res 2005 310: 99 104.