Targeting oncogenes to improve breast cancer chemotherapy

Cancer Research

Volumn 66, Issue 8, 2006, Pages 4089-4094

  Christensen, Laura A ^a   Finch, Rick A ^b   Booker, Adam J ^a   Vasquez, Karen M ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; GEMCITABINE; NUCLEOSIDE DERIVATIVE; OLIGONUCLEOTIDE;

ANCHORAGE INDEPENDENT GROWTH; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA CROSS LINKING; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA SYNTHESIS; DRUG MECHANISM; GENE INDUCTION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION TERMINATION;

ADENOCARCINOMA; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BASE SEQUENCE; BREAST NEOPLASMS; CELL ADHESION; CELL GROWTH PROCESSES; CELL LINE, TUMOR; DEOXYCYTIDINE; DNA DAMAGE; DRUG SYNERGISM; GENE EXPRESSION; GENES, MYC; HUMANS; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES; TRANSCRIPTION, GENETIC;

EID: 33646241066     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-4288     Document Type: Article

References (28)

1. Crowther PJ, Cooper IA, Woodcock DM. Biology of cell killing by 1-β-D-arabinofuranosylcytosine and its relevance to molecular mechanisms of cytotoxicity. Cancer Res 1985;45:4291-300.
2. Huang P, Plunkett W. Fludarabine- and gemcitabine-induced apoptosis: incorporation of analogs into DNA is a critical event. Cancer Chemother Pharmacol 1995;36:181-8.
3. Sandler A, Ettinger DS. Gemcitabine: single-agent and combination therapy in non-small cell lung cancer. Oncologist 1999;4:241-51.
4. Storniolo AM, Enas NH, Brown CA, Voi M, Rothenberg ML, Schilsky R. An investigational new drug treatment program for patients with gemcitabine: results for over 3000 patients with pancreatic carcinoma. Cancer 1999;85:1261-8.
5. Yang LY, Li L, Jiang H, Shen Y, Plunkett W. Expression of ERCC1 antisense RNA abrogates gemcitabine-mediated cytotoxic synergism with cisplatin in human colon tumor cells defective in mismatch repair but proficient in nucleotide excision repair. Clin Cancer Res 2000;6:773-81.
6. Robertson LE, Kantarjian H, O'Brien S, et al. Cisplatin, fludarabine, and ara-C(PFA): a regimen for advanced fluarabine-refractory chronic lymphocytic leukemia (CLL). Pro Am Soc Clin Oncol 1993;12:308.
7. Robertson LE, O'Brien S, Kantarjian H, et al. Fludarabine plus doxorubicin in previously treated chronic lymphocytic leukemia. Leukemia 1995;9:943-5.
8. Keating MJ, O'Brien S, McLaughlin P, Kantarjian H, Cabanillas F. Fludarabine in combinations in the management of chronic lymphocytic leukemia and low grade lymphoma. Ann Oncol 1996;7:1996.
9. McLaughlin P, Hagemeister FB, Romaguera JE, et al. Fludarabine, mitoxantrone, and dexamethasone: an effective new regimen for indolent lymphoma. J Clin Oncol 1996;14:1262-8.
10. Cooney M, Czernuszewicz G, Postel EH, Flint SJ, Hogan ME. Site-specific oligonucleotide binding represses transcription of the human c-myc gene in vitro. Science 1988;241:456-9.
11. Beal PA, Dervan PB. Second structural motif for recognition of DNA by oligonucleotide-directed triple-helix formation. Science 1991;251:1360-3.
12. Maher LJD, Wold B, Dervan PB. Inhibition of DNA binding proteins by oligonucleotide-directed triple helix formation. Science 1989;245:725-30.
13. Mayfield C, Squibb M, Miller D. Inhibition of nuclear protein binding to the human Ki-ras promoter by triplex-forming oligonucleotides. Biochemistry 1994;33:3358-63.
14. Samadashwily GM, Mirkin SM. Trapping DNA polymerases using triplex-forming oligodeoxyribonucleotides. Gene 1994;149:127-36.
15. Giovannangeli C, Perrouault L, Escude C, Gryaznov S, Helene C. Efficient inhibition of transcription elongation in vitro by oligonucleotide phosphoramidates targeted to proviral HIV DNA. J Mol Biol 1996;261:386-98.
16. Krasilnikov AS, Panyutin, IG, Samadashwily GM, Cox R, Lazurkin YS, Mirkin SM. Mechanisms of triplex-caused polymerization arrest Nucleic Acids Res 1997;25:1339-46.
17. Ebbinghaus SW, Fortinberry H, Gamper HBJ. Inhibition of transcription elongation in the HER-2/neu coding sequence by triplex-directed covalent modification of the template strand. Biochemistry 1999;38:619-28.
18. Vasquez KM, Wilson JH. Triplex-directed modification of genes and gene activity. Trends Biochem Sci 1998;23:4-9.
19. Wu Q, Christensen LA, Legerski RJ, Vasquez KM. Mismatch repair participates in error-free processing of DNA interstrand cross-links in human cells. EMBO J 2005;6:551-7.
20. Vasquez KM, Christensen J, Li L, Finch RA, Glazer PM. Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions. Proc Natl Acad Sci U S A 2002;99:5848-53.
21. Wang G, Seidman MM, Glazer PM. Mutagenesis in mammalian cells induced by triple helix formation and transcription-coupled repair. Science 1996;271:802-5.
22. Liao DJ, Dickson RB. c-Myc in breast cancer. Endocr Relat Cancer 2000;7:143-64.
23. Berns EM, Foekens JA, van Staveren IL, et al. Oncogene amplification and prognosis in breast cancer: relationship with systemic treatment. Gene 1995;159:11-8.
24. Berns EM, Klijn JG, Smid M, et al. TP53 and MYC gene alterations independently predict poor prognosis in breast cancer patients. Genes Chromosomes Cancer 1996;16:170-9.
25. Zendegui JG, Vasquez KM, Tinsley JH, Kessler DJ, Hogan ME. In vivo stability and kinetics of absorption and disposition of 3′ phosphopropyl amine oligonucleotides. Nucleic Acids Res 1992;20:307-14.
26. Kim H-G, Reddoch JF, Mayfield C, et al. Inhibition of transcription of the human c-myc proto-oncogene by intermolecular triplex. Biochemistry 1998;37:2299-304.
27. Catapano CV, McGuffie EM, Pacheco D, Carbone GMR. Inhibition of gene expression and cell proliferation by triple helix-forming oligonucleotides directed to the c-myc gene. Biochemistry 2000;39:5126-38.
28. Kozbor D, Croce CM. Amplification of the c-myc oncogene in one of five human breast carcinoma cell lines. Cancer Res 1984;44:438-41.