Oral branched-chain amino acid supplementation improves the oxidized/ reduced albumin ratio in patients with liver cirrhosis

Hepatology Research

Volumn 37, Issue 9, 2007, Pages 765-770

  Fukushima, Hideki ^a   Miwa, Yoshiyuki ^a   Shiraki, Makoto ^a   Gomi, Ikuko ^a   Toda, Katsuhisa ^a   Kuriyama, Shoko ^a   Nakamura, Hironori ^a   Wakahara, Toshitatsu ^a   Era, Seiichi ^a   Moriwaki, Hisataka ^a  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Branched chain amino acids (BCAA); Human mercaptalbumin (HMA); Human non mercaptalbumin (HNA); Liver cirrhosis; Oxidize dalbumin; Reduced albumin

Indexed keywords

ALBUMIN; AMINO ACID; BRANCHED CHAIN AMINO ACID; GLUTATHIONE; ISOLEUCINE; LEUCINE; LIPID PEROXIDE; LIVACT GRANULES; SELENIUM; UNCLASSIFIED DRUG; VALINE; ZINC;

ADULT; AGED; ALBUMIN BLOOD LEVEL; AMINO ACID BLOOD LEVEL; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE CLASSIFICATION; DRUG EFFICACY; FEASIBILITY STUDY; FEMALE; HEPATITIS C; HEPATITIS NON B NON C; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER CIRRHOSIS; MALE; NORMAL DISTRIBUTION; PRIORITY JOURNAL; ZINC BLOOD LEVEL;

EID: 34447301490     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2007.00123.x     Document Type: Article

References (21)

1. Tajika M, Kato M, Mohri H et al. Prognostic value of energy metabolism in patients with viral liver cirrhosis. Nutrition 2002; 18: 229-34.
2. Marchesini G, Bianchi G, Amodio P et al. Factors associated with poor health-related quality of life of patients with cirrhosis. Gastroenterology 2001; 120: 170-8.
3. Muto Y, Sato S, Watanabe A et al. Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis. Clin Gastroenterol Hepatol 2005; 3: 705-13.
4. Marchesini G, Bianchi G, Merli M et al. Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: A double-blind, randomized trial. Gastroenterology 2003; 124: 1792-801.
5. Okuno M, Moriwaki H, Kato M, Muto Y, Kojima S. Changes in the ratio of branched-chain to aromatic amino acids affect the secretion of albumin in cultured rat hepatocytes. Biochem Biophys Res Commun 1995; 214: 1045-50.
6. Quinlan GJ, Martin GS, Evans TW. Albumin: Biochemical properties and therapeutic potential. Hepatology 2005; 41: 1211-19.
7. Sogami M, Petersen HA, Foster JF. The microheterogeneity of plasma albumins. Permutations in disulfide pairings as a probable source of microheterogeneity in bovine albumin. Biochemistry 1969; 8: 49-58.
8. Watanabe A, Matsuzaki S, Moriwaki H, Suzuki K, Nishiguchi S. Problems in serum albumin measurement and clinical significance of albumin microheterogeneity in cirrhotics. Nutrition 2004; 20: 351-7.
9. Hayashi H, Takikawa T, Nishimura N, Yano M, Isomura T, Sakamoto N. Improvement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C and excess hepatic iron. Am J Gastroenterol 1994; 89: 986-8.
10. Powell EE, Jonsson JR, Clouston AD. Steatosis: Co-factor in other liver diseases. Hepatology 2005; 42: 5-13.
11. Hayashi T, Suda K, Imai H, Era S. Simple and sensitive high-performance liquid chromatographic method for the investigation of dynamic changes in the redox state of rat serum albumin. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 772: 139-46.
12. Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J. Amino acid sufficiency and mTOR regulate p70, S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 1998; 273: 14484-94.
13. Sogami M, Nagoka S, Era S, Honda M, Noguchi K. Resolution of human mercapt- and non-mercaptalbumin by high-performance liquid chromatography. Int J Pept Protein Res 1984; 24: 96-103.
14. Terawaki H, Yoshimura K, Hasegawa T et al. Oxidative stress is enhanced in correlation with renal dysfunction: Examination with the redox state of albumin. Kidney Int 2004; 66: 1988-93.
15. Halliwell B, Gutteridge JMC. The antioxidants of human extracellular fluids. Arch Biochem Biophys 1990; 280: 1-8.
16. Kawakami A, Kubota K, Yamada N et al. Identification and characterization of oxidized human serum albumin. A slight structural change impairs its ligand-binding and antioxidant functions. FEBS J 2006; 273: 3346-57.
17. Younossi ZM, McCullough AJ, Ong JP et al. Obesity and non-alcoholic fatty liver disease in chronic hepatitis C. J Clin Gastroenterol 2004; 38: 705-9.
18. Fartoux L, Poujol-Robert A, Guechot J, Wendum D, Poupon R, Serfaty L. Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C. Gut 2005; 54: 1003-8.
19. Muto Y, Sato S, Watanabe A et al. Overweight and obesity increase the risk for liver cancer in patients with liver cirrhosis and long-term oral supplementation with branched-chain amino acid granules inhibits liver carcinogenesis in heavier patients with liver cirrhosis. Hepatol Res 2006; 35: 204-14.
20. Moriwaki H, Miwa Y, Tajika M, Kato M, Fukushima H, Shiraki M. Branched-chain amino acids as a protein- and energy-source in liver cirrhosis. Biochem Biophys Res Commun 2004; 313: 405-9.
21. Lynch CJ, Patson BJ, Goodman SA, Trapolsi D, Kimball SR. Zinc stimulates the activity of the insulin- and nutrient-regulated protein kinase mTOR. Am J Physiol Endocrinol Metab 2001; 281: E25-34.