On dichotomizing phenotypes in family-based association tests: Quantitative phenotypes are not always the optimal choice

Genetic Epidemiology

Volumn 31, Issue 5, 2007, Pages 376-382

  Fardo, David ^a,c   Celedon, Juan C ^b   Raby, Benjamin A ^b   Weiss, Scott T ^b   Lange, Christoph ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Department of Biostatistics ^*  (United States)

Author keywords

Dichotomization; Misclassification; TDT

Indexed keywords

ARTICLE; ASTHMA; CONFOUNDING VARIABLE; DISEASE PREDISPOSITION; FORCED EXPIRATORY VOLUME; GENE FREQUENCY; GENE LOCUS; GENETIC MODEL; GENETIC VARIABILITY; GENOTYPE; HERITABILITY; MARKER GENE; MULTIGENE FAMILY; PHENOTYPE; QUANTITATIVE GENETICS; QUANTITATIVE TRAIT; SIMULATION;

ALLELES; ASTHMA; CHILD; FAMILY; FEMALE; FORCED EXPIRATORY VOLUME; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC TECHNIQUES; HUMANS; MALE; MODELS, GENETIC; MODELS, STATISTICAL; PHENOTYPE; QUANTITATIVE TRAIT, HERITABLE;

EID: 34447297283     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20218     Document Type: Article

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