Synthesis of 4-O-glycosylated 1-deoxynojirimycin derivatives as disaccharide mimics-based inhibitors of human β-glucocerebrosidase

Carbohydrate Research

Volumn 342, Issue 12-13, 2007, Pages 1960-1965

  Boucheron, Charlotte ^a   Toumieux, Sylvestre ^a   Compain, Philippe ^a   Martin, Olivier R ^a   Ikeda, Kyoko ^b   Asano, Naoki ^b  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b HOKURIKU UNIVERSITY   (Japan)

Author keywords

Cellobiose mimics; Gaucher disease; Glycosidase inhibitors; Glycosylation; Iminosugars; Lysosomal diseases

Indexed keywords

CELLOBIOSE MIMICS; GAUCHER DISEASE; GLYCOSIDASE INHIBITORS; IMINOSUGARS; LYSOSOMAL DISEASES;

AMIDES; BIOMIMETICS; DERIVATIVES; DISEASES; GLYCOSYLATION; SUGARS; SYNTHESIS (CHEMICAL);

ENZYME INHIBITION;

1 DEOXYMANNONOJIRIMYCIN; 2,3,4,6 TETRA O ACETYL ALPHA DEXTRO GLUCOPYRANOSYL BROMIDE; 4 O (BETA DEXTRO GLUCOPYRANOSYL) N BUTYL 1,5 DIDEOXY 1,5 IMINO DEXTRO GLUCITOL; 4 O (BETA DEXTRO GLUCOPYRANOSYL) N BUTYL 2 O BUTYL 1,5 DIDEOXY 1,5 IMINO DEXTRO GLUCITOL; BETA GLUCOCEREBROSIDASE; DISACCHARIDE; GLUCOPYRANOSIDE; GLUCOSYLCERAMIDASE; IMINOSUGAR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; GLYCOSYLATION; HUMAN; PRIORITY JOURNAL;

1-DEOXYNOJIRIMYCIN; CARBOHYDRATE CONFORMATION; DISACCHARIDES; ENZYME INHIBITORS; GLUCOSYLCERAMIDASE; GLYCOSYLATION; HUMANS; INDICATORS AND REAGENTS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION;

TETRA;

EID: 34447295379     PISSN: 00086215     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carres.2007.03.015     Document Type: Article

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