DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types

International Journal of Oncology

Volumn 30, Issue 6, 2007, Pages 1441-1446

  Conde, Ana R ^a   Martins, Ana P ^b   Brito, Miguel ^c   Manuel, Armandina ^b   Ramos, Sância ^b   Malta Vacas, Joana ^c   Renner, Marcus ^d   Poustka, Annemarie ^d   Mollenhauer, Jan ^d   Monteiro, Carolino ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b HOSPITAL DE SANTA CRUZ   (Portugal)

^c INSTITUTO POLITÉCNICO DE LISBOA   (Portugal)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Deleted in malignant brain tumours 1; Gastric cancer; Gene expression; Immunohistochemistry; Protein expression; Real time RT PCR

Indexed keywords

CELL SURFACE RECEPTOR; DMBT1 PROTEIN, HUMAN; MESSENGER RNA; TUMOR MARKER; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; DOWN REGULATION; FEMALE; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH TUMOR;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; DOWN-REGULATION; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 34447289674     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.30.6.1441     Document Type: Article

References (42)

1. Tahara E: Molecular mechanisms of stomach carcinogenesis. J Cancer Res Clin Oncol 119: 265-272, 1993.
2. Correa P and Shiao Y: Phenotypic and genotypic events in gastric carcinogenesis. Cancer Res 54 (suppl): 1941-1943, 1994.
3. Santos NR, Seruca R, Constância M, Seixas M, Sobrinho-Simões M: Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis. Gastroenterology 110: 38-44, 1996. (Pubitemid 26021602)
4. Ming SC: Cellular and molecular pathology of gastric carcinoma and precursor lesions: A critical review. Gastric Cancer 1: 31-50, 1998.
5. Kuniyasu H, Yasui W, Yokozaki H and Tahara E: Helicobacter pylori infection and carcinogenesis of the stomach. Langenbecks Arch Surg 385: 69-74, 2000.
6. Malta-Vacas J, Aires C, Costa P, Conde AR, Ramos S, Martins AP, Monteiro C and Brito M: Differential expression of the eukaryotic release factor 3 (eRF3/GSPT1) according to gastric cancer histological types. J Clin Pathol 58: 621-625, 2005.
7. Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus K, von Deimling A and Poustka A: DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumors. Nat Genet 17: 32-39, 1997.
8. Mollenhauer J, Herbertz S, Helmke B, Kollender G, Krebs I, Madsen J, Holmskov U, Sorger K, Schmitt L, Wiemann S, Otto HF, Grone H-J and Poustka A: DMBT1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancer. Cancer Res 61: 8880-8886, 2001.
9. Mollenhauer J, Helmke B, Muller H, Kollender G, Lyer S, Diedrichs L, Holmskov U, Ligtenberg T, Herbertz S, Krebs I, Wiemann S, Madsen J, Bikker F, Schmitt L, Otto HF and Poustka A: Sequential changes of the DMBT1 expression and location in normal lung tissue and lung carcinomas. Genes Chromosomes Cancer 35: 164-169, 2002.
10. Mollenhauer J, Deichmann M, Helmke B, Muller H, Kollender G, Holmskov U, Ligtenberg T, Krebs I, Wiemann S, Bantel-Schaal U, Madsen J, Bikker F, Klauck SM, Otto HF, Moldenhauer G and Poustka A: Frequent downregulation of DMBT1 and galectin-3 in epithelial skin cancer. Int J Cancer 105: 149-157, 2003.
11. Mollenhauer J, Helmke B, Medina D, Bergmann G, Gassler N, Muller H, Lyer S, Diedrichs L, Renner M, Wittig R, Blaich S, Hamann U, Madsen J, Holmskov U, Bikker F, Ligtenberg A, Carlen A, Olsson J, Otto HF, O'Malley B and Poustka A: Carcinogen inducibility in vivo and down-regulation of DMBT1 during breast carcinogenesis. Genes Chromosomes Cancer 39: 185-194, 2004.
12. Somerville RP, Shoshan Y, Eng C, Barnett G, Miller D and Cowell JK: Molecular analysis of two putative tumour suppressor genes, PTEN and DMBT, which have been implicated in glioblastoma multiforme disease progression. Oncogene 17: 1755-1757, 1998. (Pubitemid 28482654)
13. Mori M, Shiraishi T, Tanaka S, Yamagata M, Mafune K, Tanaka Y, Ueo H, Barnard GF and Sugimachi K: Lack of DMBT1 expression in oesophageal, gastric and colon cancers. Br J Cancer 79: 211-213, 1999.
14. Takeshita H, Sato M, Shiwaku HO, Semba S, Sakurada A, Hoshi M, Hayashi Y, Tagawa Y, Ayabe H and Horii A: Expression of the DMBT1 gene is frequently suppressed in human lung cancer. Jpn J Cancer Res 90: 903-908, 1999.
15. Wu W, Kemp BL, Proctor ML, Gazdar AF, Minna JD, Hong WK and Mao L: Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer. Cancer Res 59: 1846-1851, 1999.
16. Deichmann M, Mollenhauer J, Helmke B, Thome M, Hartschuh W, Poustka A and Naher H: Analysis of losses of heterozygosity of the candidate tumour suppressor gene DMBT1 in melanoma resection specimens. Oncology 63: 166-172, 2002.
17. Kang W, Nielsen O, Fenger C, Leslie G, Holmskov U and Reid KB: Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer. Carcinogenesis 26: 1129-1137, 2005. (Pubitemid 41214307)
18. Sasaki K, Sato K, Akiyama Y, Yanagihara K, Oka M and Yamaguchi K: Peptidomics-based approach reveals the secretion of the 29-residue COOH-terminal fragment of the putative tumor suppressor protein DMBT1 from pancreatic adenocarcinoma cell lines. Cancer Res 62: 4894-4898, 2002.
19. Hustinx SR, Cao D, Maitra A, Sato N, Martin ST, Sudhir D, Iacobuzio-Donahue C, Cameron JL, Yeo CJ, Kern SE, Goggins M, Mollenhauer J, Pandey A and Hruban RH: Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression. Cancer Biol Ther 3: 1254-1261, 2004. (Pubitemid 41350962)
20. Resnick D, Pearson A and Krieger M: The SRCR superfamily: a family reminiscent of the Ig superfamily. Trends Biochem Sci 19: 5-8, 1994.
21. Vilà JM, Padilla O, Arman M, Gimferrer I and Lozano F: The scavenger receptor cysteine-rich superfamily (SRCR-SF). Structure and function of group B members. Immunologia 19: 105-121, 2000.
22. Mollenhauer J, Holmskov U, Wiemann S, Krebs I, Herbertz S, Madsen J, Kioschis P, Coy JF and Poustka A: The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability. Oncogene 4: 6233-6240, 1999.
23. Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C and Reid KB: Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule. J Biol Chem 272: 13743-13749, 1997.
24. Holmskov U, Mollenhauer J, Madsen J, Vitved L, Gronlund J, Tornoe I, Kliem A, Reid KB, Poustka A and Skjodt K: Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D. Proc Natl Acad Sci USA 96: 10794-10799, 1999.
25. Tino MJ and Wright JR: Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner: Am J Respir Cell Mol Biol 20: 759-768, 1999.
26. Vijayakumar S, Takito J, Hikita C and Al-Awqati Q: Hensin remodels the apical cytoskeleton and induces columnarization of intercalated epithelial cells: processes that resemble terminal differentiation. J Cell Biol 144: 1057-1067, 1999. (Pubitemid 29238978)
27. Mollenhauer J, Herbertz S, Holmskov U, Tolnay M, Krebs I, Merlo A, Schroder HD, Maier D, Breitling F, Wiemann S, Grone HJ and Poustka A: DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer. Cancer Res 60: 1704-1710, 2000.
28. Prakobphol A, Xu F, Hoang VM, Larsson T, Bergstrom J, Johansson I, Frangsmyr L, Holmskov U, Leffler H, Nilsson C, Boren T, Wright JR, Stromberg N and Fisher SJ: Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340. J Biol Chem 275: 39860-39866, 2000.
29. Ligtenberg TJ, Bikker FJ, Groenink J, Tornoe I, Leth-Larsen R, Veerman EC, Nieuw Amerongen AV and Holmskov U: Human salivary agglutinin binds to lung surfactant protein-D and is identical with scavenger receptor protein gp-340. Biochem J 359: 243-248, 2001.
30. Kang W and Reid KB: DMBT1, a regulator of mucosal homeostasis through the linking of mucosal defense and regeneration? FEBS Lett 1540: 21-25, 2003.
31. Mueller A, O'Rourke J, Chu P, Kim CC, Sutton P, Lee A and Falkow S: Protective immunity against Helicobacter is characterized by a unique transcriptional signature. Proc Natl Acad Sci USA 100: 12289-12294, 2003. (Pubitemid 37271553)
32. Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, Stemmermann GN and Nomura A: Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 55: 2111-2115, 1995.
33. Peek RM Jr and Blaser MJ: Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer 2: 28-37, 2002.
34. Hamilton SR and Aaltonen LA: Pathology and genetics of tumours of the digestive system. In: WHO Classification of Tumors (ed). IARC Press, Lyon, pp39-67, 2000.
35. Laurén P: The two main histological types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 64: 31-49, 1965.
36. Hsu SM, Raine L and Fanger H: Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures: J Histochem Cytochem 29: 577-580, 1981. (Pubitemid 11147380)
37. Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408, 2001. (Pubitemid 34164012)
38. Dua K, Williams TM and Beretta L: Translational control of the proteome: relevance to cancer. Proteomics 1: 1191-1199, 2001. (Pubitemid 33587875)
39. Bisgaard HC, Holmskov U, Santoni-Rugiu E, Nagy P, Nielsen O, Ott P, Hage E, Dalhoff K, Rasmussen LJ and Tygstrup N: Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor 1. Am J Pathol 161: 1187-1198, 2002.
40. Hikita C, Vijayakumar S, Takito J, Erdjument-Bromage H, Tempst P and Al-Awqati Q: Induction of terminal differentiation in epithelial cells requires polymerization of hensin by galectin 3. Cell Biol 151: 1235-1246, 2000.
41. Kihlmark M, Rustum C, Eriksson C, Beckman M, Iverfeldt K and Hallberg E: Correlation between nucleocytoplasmic transport and caspase-3-dependent dismantling of nuclear pores during apoptosis. Exp Cell Res 293: 346-356, 2004.
42. Nur-E-Kamal A, Gross SR, Pan Z, Balklava Z, Ma J and Liu LF: Nuclear translocation of cytochrome c during apoptosis. J Biol Chem 279: 24911-24914, 2004.