Induction of terminal differentiation in epithelial cells requires polymerization of hensin by galectin 3

Journal of Cell Biology

Volumn 151, Issue 6, 2000, Pages 1235-1246

  Hikita, Chinami ^a   Vijayakumar, Soundarapandian ^a   Takito, Jiro ^a   Erdjument Bromage, Hediyet ^b   Tempst, Paul ^b   Al Awqati, Qais ^a  

^a Surgeons of Columbia University ^*  (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

DMBT1; Galectin; Hensin; Inside out signaling; Terminal differentiation

Indexed keywords

GALECTIN 3; HENSIN; SCLEROPROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL LINE; DENSITY; DNA FINGERPRINTING; EPITHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN POLYMERIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SECRETION; REACTION ANALYSIS; SIGNAL TRANSDUCTION;

AGGLUTININS; ANIMALS; ANTIGENS, DIFFERENTIATION; CELL DIFFERENTIATION; CELL POLARITY; COLON; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; GALECTIN 3; MEMBRANE PROTEINS; PROTEIN BINDING; RATS; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LIPOPROTEIN; RECEPTORS, SCAVENGER; SCAVENGER RECEPTORS, CLASS B; SIGNAL TRANSDUCTION;

EID: 0034638829     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.151.6.1235     Document Type: Article

References (34)

1. Galectin-3 expression and effects on cyst enlargement and tubulogenesis in kidney epithelial MDCK cells cultured in three-dimensional matrices in vitro compartment
2. A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor
3. The CUB domain: A widespread module in developmentally regulated proteins
4. CRP-ductin: A gene expressed in intestinal crypts and in pancreatic and hepatic ducts
5. Embryonic implantation in galectin 1/galectin 3 double mutant mice
6. Micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis
7. Improvement of an 'in-gel' digestion procedure for the micropreparation of internal protein fragments for amino acid sequencing
8. Only multimeric hensin located in the extracellular matrix can induce apical endocytosis and reverse the polarity of intercalated cells
9. Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D
10. Secretion of galectin family of mammalian carbohydrate-binding proteins
11. Integrin affinity modulation
12. Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain
13. Molecular cloning of Ebnerin, a von Ebner's gland protein associated with taste buds
14. Apical secretion of a cytosolic protein by Madin-Darby canine kidney cells. Evidence for polarized release of an endogenous lectin by a nonclassical secretory pathway
15. Use of mass spectrometric molecular weight information to identify proteins in databases
16. L-29, an endogenous lectin, binds to glycoconjugate ligands with positive cooperativity
17. Vomeroglandin/CRP-Ductin is strongly expressed in the glands associated with the mouse vomeronasal organ: Identification and characterization of mouse vomeroglandin
18. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumors
19. Lack of DMBT1 expression in esophageal, gastric and colon cancers
20. Galectins: Versatile modulators of cell adhesion, cell proliferation, and cell death
21. The SRCR Superfamily: A family reminiscent of the Ig superfamily
22. Regulation of secretion and surface expression of Mac-2, a galactoside-binding protein of macrophages
23. Plasticity of functional epithelial polarity
24. Fibronectin fibrillogenesis: A para-digm for extracellular matrix assembly
25. Integrin signaling in vascular biology
26. Expression of the DMBT1 gene is frequently suppressed in human lung cancer
27. Hensin, a new collecting duct protein involved in the in vivo plasticity of intercalate cell polarity
28. Hensin, the reversal of polarity protein is encoded by DMBT1, a gene frequently deleted in cancer
29. An induced extracellular matrix protein reverses the polarity of band 3 in intercalated epithelial cells
30. Hensin remodels the apical cytoskeleton and induces columnerization of intercalated epithelial cells, processes that resemble terminal differentiation
31. Epithelial galectin-3 during human nephrogenesis and childhood cystic diseases
32. New perspectives on mechanisms involved in generating epithelial cell polarity
33. Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer