New cytotoxic diterpenylnaphthohydroquinone derivatives obtained from a natural diterpenoid

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 17, 2007, Pages 5760-5774

  Miguel del Corral, José M ^a   Castro, M Angeles ^a   Lucena Rodriguez M ^a   Chamorro, Pablo ^a   Cuevas, Carmen ^b   San Feliciano, Arturo ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b PHARMAMAR S A   (Spain)

Author keywords

Allylic oxidation; Cytotoxicity; Myrcecommunic acid; Terpenylquinones

Indexed keywords

1,4 BENZOQUINONE; 1,4 NAPHTHOQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; BROMINE DERIVATIVE; CYTOTOXIC AGENT; DITERPENOID; DITERPENYLNAPHTHOHYDROQUINONE DERIVATIVE; DITERPENYLNAPHTHOHYDROQUINONE DIACETATE; ESTER DERIVATIVE; FLUORIDE; HYDROQUINONE DERIVATIVE; MYRCECOMMUNIC ACID; MYRCENE; NEW DRUG; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; AROMATIZATION; ARTICLE; CATALYST; CONTROLLED STUDY; CYCLOADDITION; DIELS ALDER REACTION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MICROWAVE IRRADIATION; TUMOR CELL LINE;

ACETYLATION; BENZENE; BIOLOGICAL PRODUCTS; CELL LINE, TUMOR; CELL PROLIFERATION; DITERPENES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROQUINONES; MAGNETIC RESONANCE SPECTROSCOPY; METHYLATION; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

ALNUS;

EID: 34447283804     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.06.005     Document Type: Article

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