-
1
-
-
0038004785
-
Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors
-
DOI 10.1038/nrd1112
-
Tobert JA: Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov 2: 517-526, 2003. (Pubitemid 37361744)
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, Issue.7
, pp. 517-526
-
-
Tobert, J.A.1
-
3
-
-
0026039147
-
Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin
-
Keyomarsi K, Sandoval L, Band V and Pardee AB: Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. Cancer Res 51: 3602-3609, 1991.
-
(1991)
Cancer Res
, vol.51
, pp. 3602-3609
-
-
Keyomarsi, K.1
Sandoval, L.2
Band, V.3
Pardee, A.B.4
-
4
-
-
0037138434
-
Potentiating antitumor effects of a combination therapy with lovastatin and butyrate in the Lewis lung carcinoma model in mice
-
Giermasz A, Makowski M, Kozlowska E, Nowis D, Maj M, Jalili A, Feleszko W, Wojcik C, Dabrowska A, Jakobisiak M and Golab J: Potentiating antitumor effects of a combination therapy with lovastatin and butyrate in the Lewis lung carcinoma model in mice. Int J Cancer 97: 746-750, 2002.
-
(2002)
Int J Cancer
, vol.97
, pp. 746-750
-
-
Giermasz, A.1
Makowski, M.2
Kozlowska, E.3
Nowis, D.4
Maj, M.5
Jalili, A.6
Feleszko, W.7
Wojcik, C.8
Dabrowska, A.9
Jakobisiak, M.10
Golab, J.11
-
5
-
-
0031784485
-
Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis
-
Alonso DF, Farina HG, Skilton G, Gabri MR, De Lorenzo MS and Gomez DE: Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis. Breast Cancer Res Treat 50: 83-93, 1998.
-
(1998)
Breast Cancer Res Treat
, vol.50
, pp. 83-93
-
-
Alonso, D.F.1
Farina, H.G.2
Skilton, G.3
Gabri, M.R.4
De Lorenzo, M.S.5
Gomez, D.E.6
-
6
-
-
84988281451
-
Inhibitory effect of Lovastatin on spontaneous metastases derived from a rat lymphoma
-
Matar P, Rozados VR, Binda MM, Roggero EA, Bonfil RD and Scharovsky OG: Inhibitory effect of Lovastatin on spontaneous metastases derived from a rat lymphoma. Clin Exp Metastasis 17: 19-25, 1999.
-
(1999)
Clin Exp Metastasis
, vol.17
, pp. 19-25
-
-
Matar, P.1
Rozados, V.R.2
Binda, M.M.3
Roggero, E.A.4
Bonfil, R.D.5
Scharovsky, O.G.6
-
7
-
-
0028947890
-
In vivo enhanced antitumor activity of carmustine [N,N′-bis(2- chloroethyl)-N-nitrosourea] by simvastatin
-
Soma MR, Baetta R, De Renzis MR, Mazzini G, Davegna C, Magrassi L, Butti G, Pezzotta S, Paoletti R and Fumagalli R: In vivo enhanced antitumor activity of carmustine [N,N′-bis(2-chloroethyl)-N-nitrosourea] by simvastatin. Cancer Res 55: 597-602, 1995.
-
(1995)
Cancer Res
, vol.55
, pp. 597-602
-
-
Soma, M.R.1
Baetta, R.2
De Renzis, M.R.3
Mazzini, G.4
Davegna, C.5
Magrassi, L.6
Butti, G.7
Pezzotta, S.8
Paoletti, R.9
Fumagalli, R.10
-
8
-
-
0027718251
-
Metastasis of B16F10 mouse melanoma inhibited by lovastatin, an inhibitor of cholesterol biosynthesis
-
Jani JP, Specht S, Stemmler N, Blanock K, Singh SV, Gupta V and Katoh A: Metastasis of B16F10 mouse melanoma inhibited by lovastatin, an inhibitor of cholesterol biosynthesis. Invasion Metastasis 13: 314-324, 1993.
-
(1993)
Invasion Metastasis
, vol.13
, pp. 314-324
-
-
Jani, J.P.1
Specht, S.2
Stemmler, N.3
Blanock, K.4
Singh, S.V.5
Gupta, V.6
Katoh, A.7
-
9
-
-
17744394863
-
Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial
-
Kawata S, Yamasaki E, Nagase T, Inui Y, Ito N, Matsuda Y, Inada M, Tamura S, Noda S, Imai Y and Matsuzawa Y: Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial. Br J Cancer 84: 886-891, 2001.
-
(2001)
Br J Cancer
, vol.84
, pp. 886-891
-
-
Kawata, S.1
Yamasaki, E.2
Nagase, T.3
Inui, Y.4
Ito, N.5
Matsuda, Y.6
Inada, M.7
Tamura, S.8
Noda, S.9
Imai, Y.10
Matsuzawa, Y.11
-
10
-
-
0030010318
-
Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer
-
Thibault A, Samid D, Tompkins AC, Figg WD, Cooper MR, Hohl RJ, Trepel J, Liang B, Patronas N, Venzon DJ, Reed E and Myers CE: Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer. Clin Cancer Res 2: 483-491, 1996.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 483-491
-
-
Thibault, A.1
Samid, D.2
Tompkins, A.C.3
Figg, W.D.4
Cooper, M.R.5
Hohl, R.J.6
Trepel, J.7
Liang, B.8
Patronas, N.9
Venzon, D.J.10
Reed, E.11
Myers, C.E.12
-
11
-
-
2942754163
-
The risk of cancer in users of statins
-
Graaf MR, Beiderbeck AB, Egberts AC, Richel DJ and Guchelaar HJ: The risk of cancer in users of statins. J Clin Oncol 22: 2388-2394, 2004.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2388-2394
-
-
Graaf, M.R.1
Beiderbeck, A.B.2
Egberts, A.C.3
Richel, D.J.4
Guchelaar, H.J.5
-
12
-
-
19444364509
-
Statins and the risk of colorectal cancer
-
Poynter JN, Gruber SB, Higgins PD, Almog R, Bonner JD, Rennert HS, Low M, Greenson JK and Rennert G: Statins and the risk of colorectal cancer. N Engl J Med 352: 2184-2192, 2005.
-
(2005)
N Engl J Med
, vol.352
, pp. 2184-2192
-
-
Poynter, J.N.1
Gruber, S.B.2
Higgins, P.D.3
Almog, R.4
Bonner, J.D.5
Rennert, H.S.6
Low, M.7
Greenson, J.K.8
Rennert, G.9
-
13
-
-
1542329169
-
Statin use and cancer risk in the General Practice Research Database
-
DOI 10.1038/sj.bjc.6601566
-
Kaye JA and Jick H: Statin use and cancer risk in the General Practice Research Database. Br J Cancer 90: 635-637, 2004. (Pubitemid 38297203)
-
(2004)
British Journal of Cancer
, vol.90
, Issue.3
, pp. 635-637
-
-
Kaye, J.A.1
Jick, H.2
-
14
-
-
33644846806
-
Use of statins and breast cancer: A meta-analysis of seven randomized clinical trials and nine observational studies
-
Bonovas S, Filioussi K, Tsavaris N and Sitaras NM: Use of statins and breast cancer: a meta-analysis of seven randomized clinical trials and nine observational studies. J Clin Oncol 23: 8606-8612, 2005.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8606-8612
-
-
Bonovas, S.1
Filioussi, K.2
Tsavaris, N.3
Sitaras, N.M.4
-
15
-
-
0036227123
-
Statin use and the risk of breast and prostate cancer
-
DOI 10.1097/00001648-200205000-00005
-
Coogan PF, Rosenberg L, Palmer JR, Strom BL, Zauber AG and Shapiro S: Statin use and the risk of breast and prostate cancer. Epidemiology 13: 262-267, 2002. (Pubitemid 34415845)
-
(2002)
Epidemiology
, vol.13
, Issue.3
, pp. 262-267
-
-
Coogan, P.F.1
Rosenberg, L.2
Palmer, J.R.3
Strom, B.L.4
Zauber, A.G.5
Shapiro, S.6
-
16
-
-
0142185511
-
The antineoplastic role of bisphosphonates: From basic research to clinical evidence
-
Santini D, Vespasiani Gentilucci U, Vincenzi B, Picardi A, Vasaturo F, La Cesa A, Onori N, Scarpa S and Tonini G: The antineoplastic role of bisphosphonates: from basic research to clinical evidence. Ann Oncol 14: 1468-1476, 2003.
-
(2003)
Ann Oncol
, vol.14
, pp. 1468-1476
-
-
Santini, D.1
Vespasiani Gentilucci, U.2
Vincenzi, B.3
Picardi, A.4
Vasaturo, F.5
La Cesa, A.6
Onori, N.7
Scarpa, S.8
Tonini, G.9
-
17
-
-
5444262558
-
Bisphosphonates: Clinical experience
-
Coleman RE: Bisphosphonates: clinical experience. Oncologist 9 (suppl 4): 14-27, 2004.
-
(2004)
Oncologist
, vol.9
, Issue.SUPPL. 4
, pp. 14-27
-
-
Coleman, R.E.1
-
18
-
-
9044219839
-
Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma
-
Myeloma Aredia Study Group
-
Berenson JR, Lichtenstein A, Porter L, Dimopoulos MA, Bordoni R, George S, Lipton A, Keller A, Ballester O, Kovacs MJ, Blacklock HA, Bell R, Simeone J, Reitsma DJ, Heffernan M, Seaman J and Knight RD: Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group. N Engl J Med 334: 488-493, 1996.
-
(1996)
N Engl J Med
, vol.334
, pp. 488-493
-
-
Berenson, J.R.1
Lichtenstein, A.2
Porter, L.3
Dimopoulos, M.A.4
Bordoni, R.5
George, S.6
Lipton, A.7
Keller, A.8
Ballester, O.9
Kovacs, M.J.10
Blacklock, H.A.11
Bell, R.12
Simeone, J.13
Reitsma, D.J.14
Heffernan, M.15
Seaman, J.16
Knight, R.D.17
-
19
-
-
10544228130
-
Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases
-
Protocol 19 Aredia Breast Cancer Study Group
-
Hortobagyi GN, Theriault RL, Porter L, Blayney D, Lipton A, Sinoff C, Wheeler H, Simeone JF, Seaman J and Knight RD: Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. Protocol 19 Aredia Breast Cancer Study Group. N Engl J Med 335: 1785-1791, 1996.
-
(1996)
N Engl J Med
, vol.335
, pp. 1785-1791
-
-
Hortobagyi, G.N.1
Theriault, R.L.2
Porter, L.3
Blayney, D.4
Lipton, A.5
Sinoff, C.6
Wheeler, H.7
Simeone, J.F.8
Seaman, J.9
Knight, R.D.10
-
20
-
-
0033050818
-
Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions: A randomized, placebo-controlled trial
-
Protocol 18 Aredia Breast Cancer Study Group
-
Theriault RL, Lipton A, Hortobagyi GN, Leff R, Gluck S, Stewart JF, Costello S, Kennedy I, Simeone J, Seaman JJ, Knight RD, Mellars K, Heffernan M and Reitsma DJ: Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions: a randomized, placebo-controlled trial. Protocol 18 Aredia Breast Cancer Study Group. J Clin Oncol 17: 846-854, 1999.
-
(1999)
J Clin Oncol
, vol.17
, pp. 846-854
-
-
Theriault, R.L.1
Lipton, A.2
Hortobagyi, G.N.3
Leff, R.4
Gluck, S.5
Stewart, J.F.6
Costello, S.7
Kennedy, I.8
Simeone, J.9
Seaman, J.J.10
Knight, R.D.11
Mellars, K.12
Heffernan, M.13
Reitsma, D.J.14
-
21
-
-
0026318521
-
Bisphosphonates. Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease
-
Fleisch H: Bisphosphonates. Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease. Drugs 42: 919-944, 1991.
-
(1991)
Drugs
, vol.42
, pp. 919-944
-
-
Fleisch, H.1
-
22
-
-
0037274983
-
Treatment of hypercalcemia of malignancy with bisphosphonates
-
Berenson JR: Treatment of hypercalcemia of malignancy with bisphosphonates. Semin Oncol 29: 12-18, 2002.
-
(2002)
Semin Oncol
, vol.29
, pp. 12-18
-
-
Berenson, J.R.1
-
23
-
-
0035146537
-
Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates
-
Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH and Rogers MJ: Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther 296: 235-242, 2001.
-
(2001)
J Pharmacol Exp Ther
, vol.296
, pp. 235-242
-
-
Dunford, J.E.1
Thompson, K.2
Coxon, F.P.3
Luckman, S.P.4
Hahn, F.M.5
Poulter, C.D.6
Ebetino, F.H.7
Rogers, M.J.8
-
24
-
-
0031977199
-
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
-
Luckman SP, Hughes DE, Coxon FP, Graham R, Russell G and Rogers MJ: Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res 13: 581-589, 1998.
-
(1998)
J Bone Miner Res
, vol.13
, pp. 581-589
-
-
Luckman, S.P.1
Hughes, D.E.2
Coxon, F.P.3
Graham, R.4
Russell, G.5
Rogers, M.J.6
-
25
-
-
20444486612
-
Bisphosphonates and cancer-induced bone disease: Beyond their antiresorptive activity
-
DOI 10.1158/0008-5472.CAN-05-0264
-
Clezardin P, Ebetino FH and Fournier PG: Bisphosphonates and cancer-induced bone disease: beyond their antiresorptive activity. Cancer Res 65: 4971-4974, 2005. (Pubitemid 40827299)
-
(2005)
Cancer Research
, vol.65
, Issue.12
, pp. 4971-4974
-
-
Clezardin, P.1
Ebetino, F.H.2
Fournier, P.G.J.3
-
26
-
-
0037236978
-
Zoledronic acid exhibits inhibitory effects on osteoblastic and osteolytic metastases of prostate cancer
-
Corey E, Brown LG, Quinn JE, Poot M, Roudier MP, Higano CS and Vessella RL: Zoledronic acid exhibits inhibitory effects on osteoblastic and osteolytic metastases of prostate cancer. Clin Cancer Res 9: 295-306, 2003.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 295-306
-
-
Corey, E.1
Brown, L.G.2
Quinn, J.E.3
Poot, M.4
Roudier, M.P.5
Higano, C.S.6
Vessella, R.L.7
-
27
-
-
3042729728
-
Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model
-
Hiraga T, Williams PJ, Ueda A, Tamura D and Yoneda T: Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model. Clin Cancer Res 10: 4559-4567, 2004.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4559-4567
-
-
Hiraga, T.1
Williams, P.J.2
Ueda, A.3
Tamura, D.4
Yoneda, T.5
-
28
-
-
0345060472
-
Antitumor activity of bisphosphonates
-
Smith MR: Antitumor activity of bisphosphonates. Clin Cancer Res 9: 5433-5434, 2003.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5433-5434
-
-
Smith, M.R.1
-
29
-
-
0042525796
-
Zoledronic acid exhibits inhibitory effects on osteoblastic and osteolytic metastases of prostate cancer
-
author reply 3216
-
Santini D, Vincenzi B, Tonini G, Scarpa S and Baldi A: Zoledronic acid exhibits inhibitory effects on osteoblastic and osteolytic metastases of prostate cancer. Clin Cancer Res 9: 3215; author reply 3216, 2003.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3215
-
-
Santini, D.1
Vincenzi, B.2
Tonini, G.3
Scarpa, S.4
Baldi, A.5
-
30
-
-
0036721078
-
Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid
-
Wood J, Bonjean K, Ruetz S, Bellahcene A, Devy L, Foidart JM, Castronovo V and Green JR: Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. J Pharmacol Exp Ther 302: 1055-1061, 2002.
-
(2002)
J Pharmacol Exp Ther
, vol.302
, pp. 1055-1061
-
-
Wood, J.1
Bonjean, K.2
Ruetz, S.3
Bellahcene, A.4
Devy, L.5
Foidart, J.M.6
Castronovo, V.7
Green, J.R.8
-
31
-
-
10744227993
-
Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients
-
Santini D, Vincenzi B, Dicuonzo G, Avvisati G, Massacesi C, Battistoni F, Gavasci M, Rocci L, Tirindelli MC, Altomare V, Tocchini M, Bonsignori M and Tonini G: Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients. Clin Cancer Res 9: 2893-2897, 2003.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2893-2897
-
-
Santini, D.1
Vincenzi, B.2
Dicuonzo, G.3
Avvisati, G.4
Massacesi, C.5
Battistoni, F.6
Gavasci, M.7
Rocci, L.8
Tirindelli, M.C.9
Altomare, V.10
Tocchini, M.11
Bonsignori, M.12
Tonini, G.13
-
32
-
-
9644262751
-
Minodronate, a newly developed nitrogen-containing bisphosphonate, suppresses melanoma growth and improves survival in nude mice by blocking vascular endothelial growth factor signaling
-
Yamagishi S, Abe R, Inagaki Y, Nakamura K, Sugawara H, Inokuma D, Nakamura H, Shimizu T, Takeuchi M, Yoshimura A, Bucala R, Shimizu H and Imaizumi T: Minodronate, a newly developed nitrogen-containing bisphosphonate, suppresses melanoma growth and improves survival in nude mice by blocking vascular endothelial growth factor signaling. Am J Pathol 165: 1865-1874, 2004.
-
(2004)
Am J Pathol
, vol.165
, pp. 1865-1874
-
-
Yamagishi, S.1
Abe, R.2
Inagaki, Y.3
Nakamura, K.4
Sugawara, H.5
Inokuma, D.6
Nakamura, H.7
Shimizu, T.8
Takeuchi, M.9
Yoshimura, A.10
Bucala, R.11
Shimizu, H.12
Imaizumi, T.13
-
33
-
-
20044389681
-
Bisphosphonates in breast cancer
-
Coleman RE: Bisphosphonates in breast cancer. Ann Oncol 16: 687-695, 2005.
-
(2005)
Ann Oncol
, vol.16
, pp. 687-695
-
-
Coleman, R.E.1
-
34
-
-
20644449488
-
Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: A randomized, placebo-controlled trial
-
Kohno N, Aogi K, Minami H, Nakamura S, Asaga T, Iino Y, Watanabe T, Goessl C, Ohashi Y and Takashima S: Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: a randomized, placebo-controlled trial. J Clin Oncol 23: 3314-3321, 2005.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3314-3321
-
-
Kohno, N.1
Aogi, K.2
Minami, H.3
Nakamura, S.4
Asaga, T.5
Iino, Y.6
Watanabe, T.7
Goessl, C.8
Ohashi, Y.9
Takashima, S.10
-
35
-
-
0242610350
-
Combined Therapy with a New Bisphosphonate, Minodronate (YM529), and Chemotherapy for Multiple Organ Metastases of Small Cell Lung Cancer Cells in Severe Combined Immunodeficient Mice
-
Yano S, Zhang H, Hanibuchi M, Miki T, Goto H, Uehara H and Sone S: Combined therapy with a new bisphosphonate, minodronate (YM529) and chemotherapy for multiple organ metastases of small cell lung cancer cells in severe combined immunodeficient mice. Clin Cancer Res 9: 5380-5385, 2003. (Pubitemid 37413593)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.14
, pp. 5380-5385
-
-
Yano, S.1
Zhang, H.2
Hanibuchi, M.3
Miki, T.4
Goto, H.5
Uehara, H.6
Sone, S.7
-
36
-
-
25144456440
-
Effect of combination therapy with a novel bisphosphonate, minodronate (YM529) and docetaxel on a model of bone metastasis by human transitional cell carcinoma
-
Inoue K, Karashima T, Fukata S, Nomura A, Kawada C, Kurabayashi A, Furihata M, Ohtsuki Y and Shuin T: Effect of combination therapy with a novel bisphosphonate, minodronate (YM529) and docetaxel on a model of bone metastasis by human transitional cell carcinoma. Clin Cancer Res 11: 6669-6677, 2005.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 6669-6677
-
-
Inoue, K.1
Karashima, T.2
Fukata, S.3
Nomura, A.4
Kawada, C.5
Kurabayashi, A.6
Furihata, M.7
Ohtsuki, Y.8
Shuin, T.9
-
37
-
-
11144254409
-
Sequence- And schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells
-
DOI 10.1002/ijc.20602
-
Neville-Webbe HL, Rostami-Hodjegan A, Evans CA, Coleman RE and Holen I: Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells. Int J Cancer 113: 364-371, 2005. (Pubitemid 40038702)
-
(2005)
International Journal of Cancer
, vol.113
, Issue.3
, pp. 364-371
-
-
Neville-Webbe, H.L.1
Rostami-Hodjegan, A.2
Evans, C.A.3
Coleman, R.E.4
Holen, I.5
-
38
-
-
12844285156
-
Synergistic cytotoxic effects of zoledronic acid and radiation in human prostate cancer and myeloma cell lines
-
DOI 10.1016/j.ijrobp.2004.09.065, PII S0360301604027002
-
Algur E, Macklis RM and Hafeli UO: Synergistic cytotoxic effects of zoledronic acid and radiation in human prostate cancer and myeloma cell lines. Int J Radiat Oncol Biol Phys 61: 535-542, 2005. (Pubitemid 40164451)
-
(2005)
International Journal of Radiation Oncology Biology Physics
, vol.61
, Issue.2
, pp. 535-542
-
-
Algur, E.1
MacKlis, R.M.2
Hafeli, U.O.3
-
39
-
-
33646368015
-
Additive growth inhibitory effects of ibandronate and antiestrogens in estrogen receptor-positive breast cancer cell lines
-
DOI 10.1186/bcr1363
-
Journe F, Chaboteaux C, Magne N, Duvillier H, Laurent G and Body JJ: Additive growth inhibitory effects of ibandronate and antiestrogens in estrogen receptor-positive breast cancer cell lines. Breast Cancer Res 8: R2, 2005. (Pubitemid 44644837)
-
(2006)
Breast Cancer Research
, vol.8
, Issue.1
-
-
Journe, F.1
Chaboteaux, C.2
Magne, N.3
Duvillier, H.4
Laurent, G.5
Body, J.-J.6
-
40
-
-
0032005580
-
Potentiated antitumour effects of cisplatin and lovastatin against MmB16 melanoma in mice
-
Feleszko W, Zagozdzon R, Golab J and Jakobisiak M: Potentiated antitumour effects of cisplatin and lovastatin against MmB16 melanoma in mice. Eur J Cancer 34: 406-411, 1998.
-
(1998)
Eur J Cancer
, vol.34
, pp. 406-411
-
-
Feleszko, W.1
Zagozdzon, R.2
Golab, J.3
Jakobisiak, M.4
-
41
-
-
6844259872
-
G-CSF prevents the suppression of bone marrow hematopoiesis induced by IL-12 and augments its anti-tumor activity in a melanoma model in mice
-
Golab J, Stoklosa T, Zagozdzon R, Kaca A, Giermasz A, Pojda Z, Machaj E, Dabrowska A, Feleszko W, Lasek W, Iwan-Osiecka A and Jakobisiak M: G-CSF prevents the suppression of bone marrow hematopoiesis induced by IL-12 and augments its anti-tumor activity in a melanoma model in mice. Ann Oncol 9: 63-69, 1998.
-
(1998)
Ann Oncol
, vol.9
, pp. 63-69
-
-
Golab, J.1
Stoklosa, T.2
Zagozdzon, R.3
Kaca, A.4
Giermasz, A.5
Pojda, Z.6
Machaj, E.7
Dabrowska, A.8
Feleszko, W.9
Lasek, W.10
Iwan-Osiecka, A.11
Jakobisiak, M.12
-
42
-
-
33745074201
-
Heme oxygenase-1 protects tumor cells against photodynamic therapy-mediated cytotoxicity
-
Nowis D, Legat M, Grzela T, Niderla J, Wilczek E, Wilczynski GM, Glodkowska E, Mrowka P, Issat T, Dulak J, Jozkowicz A, Was H, Adamek M, Wrzosek A, Nazarewski S, Makowski M, Stoklosa T, Jakobisiak M and Golab J: Heme oxygenase-1 protects tumor cells against photodynamic therapy-mediated cytotoxicity. Oncogene 25: 3365-3374, 2006.
-
(2006)
Oncogene
, vol.25
, pp. 3365-3374
-
-
Nowis, D.1
Legat, M.2
Grzela, T.3
Niderla, J.4
Wilczek, E.5
Wilczynski, G.M.6
Glodkowska, E.7
Mrowka, P.8
Issat, T.9
Dulak, J.10
Jozkowicz, A.11
Was, H.12
Adamek, M.13
Wrzosek, A.14
Nazarewski, S.15
Makowski, M.16
Stoklosa, T.17
Jakobisiak, M.18
Golab, J.19
-
43
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou TC and Talalay P: Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22: 27-55, 1984.
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
44
-
-
2542458153
-
Potential antitumor effects of statins
-
Review
-
Jakobisiak M and Golab J: Potential antitumor effects of statins (Review). Int J Oncol 23: 1055-1069, 2003.
-
(2003)
Int J Oncol
, vol.23
, pp. 1055-1069
-
-
Jakobisiak, M.1
Golab, J.2
-
45
-
-
6944250143
-
Cerivastatin demonstrates enhanced antitumor activity against human breast cancer cell lines when used in combination with doxorubicin or cisplatin
-
Kozar K, Kaminski R, Legat M, Kopec M, Nowis D, Skierski JS, Koronkiewicz M, Jakobisiak M and Golab J: Cerivastatin demonstrates enhanced antitumor activity against human breast cancer cell lines when used in combination with doxorubicin or cisplatin. Int J Oncol 24: 1149-1157, 2004.
-
(2004)
Int J Oncol
, vol.24
, pp. 1149-1157
-
-
Kozar, K.1
Kaminski, R.2
Legat, M.3
Kopec, M.4
Nowis, D.5
Skierski, J.S.6
Koronkiewicz, M.7
Jakobisiak, M.8
Golab, J.9
-
46
-
-
12444252093
-
Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2′-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice
-
Kozar K, Kaminski R, Switaj T, Oldak T, Machaj E, Wysocki PJ, Mackiewicz A, Lasek W, Jakobisiak M and Golab J: Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2′-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice. Clin Cancer Res 9: 3124-3133, 2003.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3124-3133
-
-
Kozar, K.1
Kaminski, R.2
Switaj, T.3
Oldak, T.4
Machaj, E.5
Wysocki, P.J.6
Mackiewicz, A.7
Lasek, W.8
Jakobisiak, M.9
Golab, J.10
-
47
-
-
28844495629
-
Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies
-
Holstein SA, Knapp HR, Clamon GH, Murry DJ and Hohl RJ: Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies. Cancer Chemother Pharmacol 57: 155-164, 2006.
-
(2006)
Cancer Chemother Pharmacol
, vol.57
, pp. 155-164
-
-
Holstein, S.A.1
Knapp, H.R.2
Clamon, G.H.3
Murry, D.J.4
Hohl, R.J.5
-
48
-
-
33646783320
-
Zoledronic acid (Zometa) enhances the cytotoxic effect of gemcitabine and fluvastatin: In vitro isobologram studies with conventional and nonconventional cytotoxic agents
-
Budman DR and Calabro A: Zoledronic acid (Zometa) enhances the cytotoxic effect of gemcitabine and fluvastatin: in vitro isobologram studies with conventional and nonconventional cytotoxic agents. Oncology 70: 147-153, 2006.
-
(2006)
Oncology
, vol.70
, pp. 147-153
-
-
Budman, D.R.1
Calabro, A.2
-
49
-
-
20344365809
-
Therapy insight: Potential of statins for cancer chemoprevention and therapy
-
DOI 10.1038/ncponc0097
-
Katz MS: Therapy insight: potential of statins for cancer chemoprevention and therapy. Nat Clin Pract Oncol 2: 82-89, 2005. (Pubitemid 40790141)
-
(2005)
Nature Clinical Practice Oncology
, vol.2
, Issue.2
, pp. 82-89
-
-
Katz, M.S.1
-
50
-
-
0041333803
-
Statins and safety: Applying the results of randomized trials to clinical practice
-
Waters D: Statins and safety: applying the results of randomized trials to clinical practice. Am J Cardiol 92: 692-695, 2003.
-
(2003)
Am J Cardiol
, vol.92
, pp. 692-695
-
-
Waters, D.1
-
51
-
-
27644504641
-
RAS-blocking bisphosphonate zoledronic acid inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia cells in vitro
-
Ohtsuka Y, Manabe A, Kawasaki H, Hasegawa D, Zaike Y, Watanabe S, Tanizawa T, Nakahata T and Tsuji K: RAS-blocking bisphosphonate zoledronic acid inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia cells in vitro. Blood 106: 3134-3141, 2005.
-
(2005)
Blood
, vol.106
, pp. 3134-3141
-
-
Ohtsuka, Y.1
Manabe, A.2
Kawasaki, H.3
Hasegawa, D.4
Zaike, Y.5
Watanabe, S.6
Tanizawa, T.7
Nakahata, T.8
Tsuji, K.9
-
52
-
-
0036438907
-
Pamidronate causes apoptosis of plasma cells in vivo in patients with multiple myeloma
-
Gordon S, Helfrich MH, Sati HI, Greaves M, Ralston SH, Culligan DJ, Soutar RL and Rogers MJ: Pamidronate causes apoptosis of plasma cells in vivo in patients with multiple myeloma. Br J Haematol 119: 475-483, 2002.
-
(2002)
Br J Haematol
, vol.119
, pp. 475-483
-
-
Gordon, S.1
Helfrich, M.H.2
Sati, H.I.3
Greaves, M.4
Ralston, S.H.5
Culligan, D.J.6
Soutar, R.L.7
Rogers, M.J.8
-
53
-
-
28844486699
-
Pamidronate induced anti-proliferative, apoptotic, and anti-migratory effects in hepatocellular carcinoma
-
DOI 10.1016/j.jhep.2005.09.022, PII S016882780500663X
-
Wada A, Fukui K, Sawai Y, Imanaka K, Kiso S, Tamura S, Shimomura I and Hayashi N: Pamidronate induced antiproliferative, apoptotic and anti-migratory effects in hepatocellular carcinoma. J Hepatol 44: 142-150, 2006. (Pubitemid 41772528)
-
(2006)
Journal of Hepatology
, vol.44
, Issue.1
, pp. 142-150
-
-
Wada, A.1
Fukui, K.2
Sawai, Y.3
Imanaka, K.4
Kiso, S.5
Tamura, S.6
Shimomura, I.7
Hayashi, N.8
-
54
-
-
28844433954
-
Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells
-
Lee J, Lee I, Park C and Kang WK: Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells. Biochem Biophys Res Commun 339: 748-754, 2006.
-
(2006)
Biochem Biophys Res Commun
, vol.339
, pp. 748-754
-
-
Lee, J.1
Lee, I.2
Park, C.3
Kang, W.K.4
-
55
-
-
0034857309
-
Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells
-
Xia Z, Tan MM, Wong WW, Dimitroulakos J, Minden MD and Penn LZ: Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells. Leukemia 15: 1398-1407, 2001.
-
(2001)
Leukemia
, vol.15
, pp. 1398-1407
-
-
Xia, Z.1
Tan, M.M.2
Wong, W.W.3
Dimitroulakos, J.4
Minden, M.D.5
Penn, L.Z.6
-
56
-
-
0034655467
-
Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition
-
Tanaka T, Tatsuno I, Uchida D, Moroo I, Morio H, Nakamura S, Noguchi Y, Yasuda T, Kitagawa M, Saito Y and Hirai A: Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. J Neurosci 20: 2852-2859, 2000.
-
(2000)
J Neurosci
, vol.20
, pp. 2852-2859
-
-
Tanaka, T.1
Tatsuno, I.2
Uchida, D.3
Moroo, I.4
Morio, H.5
Nakamura, S.6
Noguchi, Y.7
Yasuda, T.8
Kitagawa, M.9
Saito, Y.10
Hirai, A.11
-
57
-
-
4644228513
-
The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate
-
Caraglia M, D'Alessandro AM, Marra M, Giuberti G, Vitale G, Viscomi C, Colao A, Prete SD, Tagliaferri P, Tassone P, Budillon A, Venuta S and Abbruzzese A: The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate. Oncogene 23: 6900-6913, 2004.
-
(2004)
Oncogene
, vol.23
, pp. 6900-6913
-
-
Caraglia, M.1
D'Alessandro, A.M.2
Marra, M.3
Giuberti, G.4
Vitale, G.5
Viscomi, C.6
Colao, A.7
Prete, S.D.8
Tagliaferri, P.9
Tassone, P.10
Budillon, A.11
Venuta, S.12
Abbruzzese, A.13
-
58
-
-
0035893740
-
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models
-
Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, Davide JP, De Solms SJ, Dinsmore CJ, Ellis-Hutchings MS, Kral AM, Liu D, Lumma WC, Machotka SV, Rands E, Williams TM, Graham SL, Hartman GD, Oliff AI, Heimbrook DC and Kohl NE: Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. Cancer Res 61: 8758-8768, 2001.
-
(2001)
Cancer Res
, vol.61
, pp. 8758-8768
-
-
Lobell, R.B.1
Omer, C.A.2
Abrams, M.T.3
Bhimnathwala, H.G.4
Brucker, M.J.5
Buser, C.A.6
Davide, J.P.7
De Solms, S.J.8
Dinsmore, C.J.9
Ellis-Hutchings, M.S.10
Kral, A.M.11
Liu, D.12
Lumma, W.C.13
Machotka, S.V.14
Rands, E.15
Williams, T.M.16
Graham, S.L.17
Hartman, G.D.18
Oliff, A.I.19
Heimbrook, D.C.20
Kohl, N.E.21
more..
-
59
-
-
27244450832
-
Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells
-
DOI 10.1111/j.1365-2141.2005.05696.x
-
Morgan MA, Sebil T, Aydilek E, Peest D, Ganser A and Reuter CW: Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells. Br J Haematol 130: 912-925, 2005. (Pubitemid 43899732)
-
(2005)
British Journal of Haematology
, vol.130
, Issue.6
, pp. 912-925
-
-
Morgan, M.A.1
Sebil, T.2
Aydilek, E.3
Peest, D.4
Ganser, A.5
Reuter, C.W.M.6
-
60
-
-
0043029517
-
Synergistic cytotoxic effects in myeloid leukemia cells upon cotreatment with farnesyltransferase and geranylgeranyl transferase-I inhibitors
-
Morgan MA, Wegner J, Aydilek E, Ganser A and Reuter CW: Synergistic cytotoxic effects in myeloid leukemia cells upon cotreatment with farnesyltransferase and geranylgeranyl transferase-I inhibitors. Leukemia 17: 1508-1520, 2003.
-
(2003)
Leukemia
, vol.17
, pp. 1508-1520
-
-
Morgan, M.A.1
Wegner, J.2
Aydilek, E.3
Ganser, A.4
Reuter, C.W.5
-
61
-
-
0034896098
-
Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death
-
Kagawa S, Gu J, Honda T, McDonnell TJ, Swisher SG, Roth JA and Fang B: Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death. Clin Cancer Res 7: 1474-1480, 2001.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1474-1480
-
-
Kagawa, S.1
Gu, J.2
Honda, T.3
McDonnell, T.J.4
Swisher, S.G.5
Roth, J.A.6
Fang, B.7
-
62
-
-
4944239035
-
An amino-bisphosphonate targets MMP-9 - Expressing macrophages and angiogenesis to impair cervical carcinogenesis
-
DOI 10.1172/JCI200422087
-
Giraudo E, Inoue M and Hanahan D: An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J Clin Invest 114: 623-633, 2004. (Pubitemid 39578752)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.5
, pp. 623-633
-
-
Giraudo, E.1
Inoue, M.2
Hanahan, D.3
-
63
-
-
17644364397
-
Clodronate treatment influences MMP-2 associated outcome in node positive breast cancer
-
Leppa S, Saarto T, Vehmanen L, Blomqvist C and Elomaa I: Clodronate treatment influences MMP-2 associated outcome in node positive breast cancer. Breast Cancer Res Treat 90: 117-125, 2005.
-
(2005)
Breast Cancer Res Treat
, vol.90
, pp. 117-125
-
-
Leppa, S.1
Saarto, T.2
Vehmanen, L.3
Blomqvist, C.4
Elomaa, I.5
-
64
-
-
2342558678
-
Simvastatin, an HMGCoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells
-
Thunyakitpisal PD and Chaisuparat R: Simvastatin, an HMGCoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells. J Pharmacol Sci 94: 403-409, 2004.
-
(2004)
J Pharmacol Sci
, vol.94
, pp. 403-409
-
-
Thunyakitpisal, P.D.1
Chaisuparat, R.2
-
65
-
-
0346826281
-
Molecular mechanism of the anti-cancer activity of cerivastatin, an inhibitor of HMG-CoA reductase, on aggressive human breast cancer cells
-
Denoyelle C, Albanese P, Uzan G, Hong L, Vannier JP, Soria J and Soria C: Molecular mechanism of the anti-cancer activity of cerivastatin, an inhibitor of HMG-CoA reductase, on aggressive human breast cancer cells. Cell Signal 15: 327-338, 2003.
-
(2003)
Cell Signal
, vol.15
, pp. 327-338
-
-
Denoyelle, C.1
Albanese, P.2
Uzan, G.3
Hong, L.4
Vannier, J.P.5
Soria, J.6
Soria, C.7
-
66
-
-
11244311877
-
The bisphosphonate acute phase response: Rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins
-
DOI 10.1111/j.1365-2249.2005.02665.x
-
Hewitt RE, Lissina A, Green AE, Slay ES, Price DA and Sewell AK: The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. Clin Exp Immunol 139: 101-111, 2005. (Pubitemid 40066134)
-
(2005)
Clinical and Experimental Immunology
, vol.139
, Issue.1
, pp. 101-111
-
-
Hewitt, R.E.1
Lissina, A.2
Green, A.E.3
Slay, E.S.4
Price, D.A.5
Sewell, A.K.6
|