Molecular mechanisms underlying wound healing and anti-inflammatory properties of naturally occurring biotechnologically produced phenylpropanoid glycosides

Cellular and Molecular Biology

Volumn 53, Issue 5, 2007, Pages 84-91

  Korkina, Liudmila G ^a,b   Mikhal'chik, E V ^b   Suprun, M V ^b   Pastore, S ^a   Dal Toso, R ^c  

^a LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^b PIROGOV RUSSIAN NATIONAL RESEARCH MEDICAL UNIVERSITY   (Russian Federation)

^c Institute of Biotechnological Research (IRB)   (Italy)

Author keywords

Chemokines; Cytokines; Experimental wounds; Free radicals; Glutathione peroxidase; Glutathione S transferase; Inflammation; Keratinocytes; Metal chelators; Myeloperoxidase; Phenylpropanoid glycosides; Plant cell cultures; Teupolioside; Verbascoside

Indexed keywords

ACTEOSIDE; CHEMOKINE; CYTOKINE; FREE RADICAL; GAMMA INTERFERON; GROWTH FACTOR; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; RUTOSIDE; TEUPOLIOSIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; GLUCOSIDE; GLYCOSIDE; PHENOL DERIVATIVE; SCAVENGER;

AJUGA; AJUGA REPTANS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; IRON CHELATION; KERATINOCYTE; LEUKOCYTE; LIPID PEROXIDATION; MALE; NONHUMAN; PLANT CELL CULTURE; PROTEIN EXPRESSION; RAT; SYRINGA; SYRINGA VULGARIS; WOUND HEALING; ADULT; ANIMAL; BIOTECHNOLOGY; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; FEMALE; METABOLISM; METHODOLOGY; MIDDLE AGED; WISTAR RAT;

AJUGA REPTANS; SYRINGA VULGARIS;

ADULT; AJUGA; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BIOTECHNOLOGY; CELLS, CULTURED; FEMALE; FREE RADICAL SCAVENGERS; GLUCOSIDES; GLYCOSIDES; HUMANS; KERATINOCYTES; MALE; MIDDLE AGED; MOLECULAR STRUCTURE; PHENOLS; PLANT EXTRACTS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SYRINGA; WOUND HEALING;

EID: 34447280138     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: 10.1170/T822     Document Type: Article

References (28)

1. Akaike, T. and Yoshida, M., Antagonistic action of imidazolineoxyl N-oxides against EDRF/NO through a radical reaction. Biochem. 1993, 32: 827-832.
2. Applegate, L.A., Luscher, P. and Tyrrell R.M., Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells. Cancer Res. 1991, 51: 974-978.
3. Braun, S., Hanselmann, C., Gassmann, M.G., auf dem Keller, U., Born-Berclaz, C., Chan, K., Kan, Y.W. and Werner S., Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound. Mol. Cell. Biol. 2002, 22: 5492-5505.
4. Cerutti P.A. and Trump B.F. Inflammation and oxidative stress in carcinogenesis. Cancer Cells 1991, 3: 1-7.
5. Denisov, E. and Afanas'ev, I., Oxidation and Antioxidants in Organic Chemistry and Biology 2005; CBC Taylor & Francis Group, Boca Raton-London- New York-Singapore.
6. Feng, R., Lu, Y., Bowman, L.L., Qian, Y., Castranova, V. and Ding, M., Inhibition of AP-1, NF-kB and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid. J. Biol. Chem. 2005, 280: 2888-2895.
7. Galey, J-B., Potential Use of Iron Chelators against Oxidative Damage. In: Advances in Pharmacology, Academic Press, Inc. 1997, 38: 167- 203.
8. George, S., Brat, P., Alter, P. and Amiot, M.J., Rapid determination of polyphenols and vitamin C in plant-derived products. J.Agric.Food Chem. 2005, 53: 1370-1373.
9. Girolomoni, G., Sebastiani, S., Albanesi, C. and Cavani, A. T-cell subpopulations in the development of atopic and contact allergy. Curr. Opin. Immunol. 2001, 13: 733-737.
10. Hanselmann, C., Mauch, C. and Werner, S., Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis? Biochem. J. 2001, 353: 459-466.
11. Hsu, S., Green tea and the skin. J. Am. Acad. Dermatol. 2005, 52: 1049-1059.
12. Korkina, L.G. and Afanas'ev, I.B. Antioxidant and chelating properties of flavonoids. Adv. Pharmacol. 1997, 38: 151-63.
13. Korkina, L., Mikhal'chik, E., Suprun, M., Minghetti, A., Crespi Perellino, N., Boninsegna, S., Pressi, G. and Dal Toso, R., Phenylpropanoids as a new class of natural chelators and antioxidants Feasibility for dermatology and cosmetology, 4th world Congress of "Cellular and molecular biology", 7-12 October, Poitiers, France, 2005: p. 72.
14. Kris-Etherton, P.M., Hecker, K.D., Bonanome, A., Coval, S.M., Binoski, A.E., Hilpert, K.F., Griel, A.E. and Etherton T.D., Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am. J. Med. 2002, 113: 715-885.
15. Kurkin, V.A., Phenylpropanoids from medicinal plants: distribution, classification, structural analysis, and biological activity. Chem Nat Compd. 2003, 39: 123-153.
16. Lee, J.Y., Woo, E.R. and Kang, K.W., Inhibition of lipopolysaccharide- inducible nitric oxide synthase expression by acteoside through blocking of AP-1 activation. J. Ethnopharmacol. 2005, 97: 561-566.
17. Martin, P. Wound healing-aiming for perfect skin regeneration. Sci. 1997, 276: 75-81.
18. Mikhal'chikm, E.V., Ivanovam, A.V., Anurovm, M.V., Titkova, S.M., Pen'kov, L.Y., Kharaeva, Z.F. and Korkina L.G., Wound-healing effect of papaya-based preparation in experimental thermal trauma. Bull. Exp. Biol. Med. 2004, 137: 560-562.
19. Minghetti, A., Una tecnologia innovativa per la produzione di principi attivi da piante. Colture cellulari di origine vegetale. Natural 1, 2003, 20: 54-57.
20. Morton, J.J.P. and Malone, M.H., Evaluation of vulnerary activity by an open wound procedure in rats. Arch. Int. Pharmacodyn. 1972, 196: 117-126.
21. Nayak, B.S., Vinutha, B., Geetha, B. and Sudha, B. Experimental evaluation of Pentas lanceolata for wound healing activity in rats. Fitotherapia 2005, 76: 671-675.
22. Pastore, S., Fanales-Belasio, E., Albanesi, C., Chinni, L.M., Giannetti, A. and Girolomoni, G. Granulocyte macrophage-colony stimulating factor is overproduced by keratinocytes in atopic dermatitis. Implications for sustained dendritic cell activation in the skin. J. Clin. Invest. 1997, 99: 3009-3017.
23. Pastore, S., Mascia, F., Mariani, V. and Girolomoni, G., Keratinocytes in skin inflammation. Expert Rev. Dermatol. 2006, and: 279-291.
24. Prestera, T., Talalay, P., Alam, J., Ahn, Y.I., Lee, P.J. and Choi, A.M. Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE). Mol. Med. 1995, 1: 827-837.
25. Steiling, H., Munz, B., Werner, S. and Brauchle, M., Different types of ROS-scavenging enzymes are expressed during cutaneous wound repair. Exp. Cell Res. 1999, 247: 484-494.
26. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M. and Impicciatore, M., Comparative screening of plant essential oils: phenilpropanoid moiety a basic core for antiplatelet activity. Life Sci. 2006, 78: 1419-1432.
27. Vile, G.F., Basu-Modak, S., Waltner, C. and Tyrrell, R.M., Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts. Proc. Natl. Acad. Sci. USA 1994; 91: 2607-2610.
28. Xia, Y. and Zweier, J.L., Measurement of myeloperoxidase in leukocyte-containing tissues. Anal. Biochem. 1997, 245: 93-96.