Transcriptomic profiling of radiation-resistant or -sensitive human colorectal cancer cells: Acute effects of a single X-radiation dose

International Journal of Oncology

Volumn 30, Issue 6, 2007, Pages 1369-1380

  Ng, Cheng E ^a   Liu, Qing Y ^b   Qutob, Sami S ^c   Scott, Bradley J ^a   Tan, Wei L ^a   Mesak, Felix M ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c HEALTH CANADA   (Canada)

Author keywords

cDNA microarray; Colorectal tumor; HCT116; Transcriptomic profiling; X radiation

Indexed keywords

ARTICLE; COLORECTAL TUMOR; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; RADIATION DOSE; RADIATION EXPOSURE; TUMOR CELL LINE; WESTERN BLOTTING; X RAY;

BLOTTING, WESTERN; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RADIATION TOLERANCE; X-RAYS;

EID: 34447274061     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.30.6.1369     Document Type: Article

References (15)

1. Andreassen CN, Alsner J and Overgaard J: Does variability in normal tissue reactions after radiotherapy have a genetic basis - where and how to look for it? Radiother Oncol 64: 131-140, 2002.
2. Khanna KK and Jackson SP: DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 27: 247-254, 2001. (Pubitemid 32201842)
3. Zhivotovsky B, Joseph B and Orrenius S: Tumor radiosensitivity and apoptosis. Exp Cell Res 248: 10-17, 1999.
4. Guo G, Yan-Sanders Y, Lyn-Cook BD, et al: Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses. Mol Cell Biol 23: 2362-2378, 2003.
5. Hartmann KA, Modlich O, Prisack HB, Gerlach B and Bojar H: Gene expression profiling of advanced head and neck squamous cell carcinomas and two squamous cell carcinoma cell lines under radio/chemotherapy using cDNA arrays. Radiother Oncol 63: 309-320, 2002.
6. Kitahara O, Katagiri T, Tsunoda T, Harima Y and Nakamura Y: Classification of sensitivity or resistance of cervical cancers to ionizing radiation according to expression profiles of 62 genes selected by cDNA microarray analysis. Neoplasia 4: 295-303, 2002.
7. Li Z, Xia L, Lee LM, et al: Effector genes altered in MCF-7 human breast cancer cells after exposure to fractionated ionizing radiation. Radiat Res 155: 543-553, 2001. (Pubitemid 32260252)
8. Park WY, Hwang CI, Im CN, et al: Identification of radiation-specific responses from gene expression profile. Oncogene 21: 8521-8528, 2002.
9. Qutob SS, Multani AS, Pathak S, Feng Y, Kendal WS and Ng CE: Comparison of the X-radiation, drug and ultraviolet-radiation responses of clones isolated from a human colorectal tumor cell line. Radiat Res 161: 326-334, 2004.
10. Brazma A, Hingamp P, Quackenbush J, et al: Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet 29: 365-371, 2001.
11. Sturn A, Quackenbush J and Trajanoski Z: Genesis: cluster analysis of microarray data. Bioinformatics 18: 207-208, 2002. (Pubitemid 34145055)
12. Desnoyers S, Kaufmann SH and Poirier GG: Alteration of the nucleolar localization of poly(ADP-ribose) polymerase upon treatment with transcription inhibitors. Exp Cell Res 227: 146-153, 1996.
13. Leong T, Chao M, Bassal S and McKay M: Radiation-hypersensitive cancer patients do not manifest protein expression abnormalities in components of the nonhomologous end-joining (NHEJ) pathway. Br J Cancer 88: 1251-1255, 2003.
14. Daboussi F, Dumay A, Delacote F and Lopez BS: DNA double-strand break repair signalling: the case of RAD51 post-translational regulation. Cell Signal 14: 969-975, 2002. (Pubitemid 35279421)
15. Marcou Y, D'Andrea A, Jeggo PA and Plowman PN: Normal cellular radiosensitivity in an adult Fanconi anaemia patient with marked clinical radiosensitivity. Radiother Oncol 60: 75-79, 2001.