Mycobacterium tuberculosis H37Rv induces monocytic release of interleukin-6 via activation of mitogen-activated protein kinases: Inhibition by N-acetyl-L-cysteine

FEMS Immunology and Medical Microbiology

Volumn 50, Issue 3, 2007, Pages 309-318

  Natarajan, Palaniappan ^a   Narayanan, Sujatha ^a  

^a NATIONAL INSTITUTE FOR RESEARCH IN TUBERCULOSIS   (India)

Author keywords

Mitogen activated protein kinases; Mycobacterium tuberculosis; N acetyl L cysteine (NAC)

Indexed keywords

ACETYLCYSTEINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38;

ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXPOSURE; HUMAN; HUMAN CELL; MONOCYTE; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; UPREGULATION;

ACETYLCYSTEINE; CELLS, CULTURED; HUMANS; INTERLEUKIN-6; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; MYCOBACTERIUM TUBERCULOSIS; PROTEIN KINASE INHIBITORS;

EID: 34447271497     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2007.00256.x     Document Type: Article

References (34)

1. Ameixa C Friedland JS (2002) Interleukin-8 secretion from Mycobacterium tuberculosis-infected monocytes is regulated by protein tyrosine kinases but not by ERK1/2 or p38 mitogen-activated protein kinases. Infect Immun 70: 4743 4746.
2. Bhattacharyya A, Pathak S, Kundu M Basu J (2002) Mitogen-activated protein kinases regulate Mycobacterium avium-induced tumor necrosis factor-alpha release from macrophages. FEMS Immunol Med Microbiol 34: 73 80.
3. Bluementhal A, Ehlers S, Ernst M, Flad HD Reiling N (2002) Control of mycobacterial replication in human macrophages: roles of extra-cellular signal-regulated kinases and p38 mitogen-activated protein kinase pathways. Infect Immun 70: 4961 4967.
4. Carter BA, Knudtson LK, Monick MM Hunninghake WG (1999) The p38 mitogen-activated protein kinase is required for NF-κB-dependent gene expression. The role of TATA-binding protein (TBP). J Biol chem 274: 30858 30863.
5. Chan DE, Morris RK, Belisle TJ, Preston H, Remigio KL, Brennan JP Riches HWD (2001) Induction of inducible nitric oxide synthase-NO·by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK-ERK, MKK7-JNK, and NF-κB signaling pathways. Infect Immun 69: 2001 2010.
6. Cheung KWB, Lee CWD, Li CBJ, Lau YL Lau SYA (2005) A role for double-stranded RNA-activated protein kinase PKR in Mycobacterium-induced cytokine expression. J Immunol 175: 7218 722.
7. Cowan JK Storey BK (2003) Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress. J Exp Biol 206: 1107 1115.
8. Craig R, Larkin A, Mingo AM, Thuerauf JD, Andrews C, McDonough MP Glembotski CC (2000) p38 MAPK and NF-κB collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system. J Biol Chem 275: 23814 23824.
9. el-Ahmady O, Mansour M, Zoeir H Mansour O (1997) Elevated concentrations of interleukins and leukotriene in response to Mycobacterium tuberculosis infection. Ann Clin Biochem 34: 160 164.
10. Ghosh S (1999) Regulation of inducible gene expression by the transcription factor NF-κB. Immunol Res 19: 183 189.
11. Haddad JJ (2001) Reduction-oxidation signaling mediating p38 MAPK-dependent regulation of pro-inflammatory cytokine biosynthesis: on the mechanism of glutathione as a novel immunoregulatory antioxidant thiol. Int Arch Biosci 1001 1013.
12. Jung SB, Yang CS, Lee JS et al 2006) The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes. Infect Immun 74: 2686 2696.
13. Koul A, Herget T, Klebl TB Ullrich A (2004) Interplay between mycobacteria and host signaling pathways. Nat Rev Microbiol 2: 189 202.
14. Lee JC, Laydon JT, McDonnell PC et al 1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372: 739 746.
15. Maiti D, Bhattacharyya A Basu J (2001) Lipoarabinomannan from Mycobacterium tuberculosis promotes macrophage survival by phosphorylating Bad through a phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem 276: 329 333.
16. Mendez-Samperio P, Palma J Vazquez A (2001) Roles of intracellular calcium and NF-κB in the Bacillus Calmette-Guerin-induced secretion of interleukin-8 from human monocytes. Cell Immunol 211: 113 122.
17. Mendez-Samperio P, Ayala H, Trejo A Ramirez FA (2004) Differential induction of TNF-α and NOS2 by mitogen-activated protein kinase signaling pathways during Mycobacterium bovis infection. J Infect 48: 66 73.
18. Moruguchi T, Kuroyanagi N, Yamaguchi K et al 1996) A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem 271: 13675 13679.
19. Nagabhushanam V, Solache A, Ting L, Escaron CJ, Zhan JY Ernst JD (2003) Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-γ. J Immunol 171: 4750 4757.
20. Newman GW, Gan HX, McCarthy PL Jr. Remold HG (1991) Survival of human macrophages infected with Mycobacterium avium intracellulare correlates with increased production of tumor necrosis factor-alpha and IL-6. J Immunol 147: 3942 3948.
21. Ogawa T, Uchida H, Kusumoto Y, Mori Y, Yamamura Y Hamada S (1991) Increase in tumor necrosis factor alpha- and interleukin-6-secreting cells in peripheral blood mononuclear cells from subjects infected with Mycobacterium tuberculosis. Infect Immun 59: 3021 3025.
22. Orme IM Cooper AM (1999) Cytokine/chemokine cascades in immunity to tuberculosis. Immunol Today 20: 307 312.
23. Rao KM (2001) MAP kinase activation in macrophages. J Leukoc Biol 69: 3 10.
24. Reiling M, Bluementhal A, Flad HD, Ernst M Ehlers S (2001) Mycobacteria-induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity. J Immunol 167: 3339 3345.
25. Riendeau JC Kornfeld H (2003) THP-1 cell apoptosis in response to mycobacterial infection. Infect Immun 71: 254 259.
26. Roach K Schorey JS (2002) Differential regulation of the mitogen-activated protein kinases by pathogenic and nonpathogenic mycobacteria. Infect Immun 70: 3040 3052.
27. Schorey JS Cooper AM (2003) Macrophage signaling upon mycobacterial infection: the MAP kinases lead the way. Cell Microbiol 5: 133 142.
28. Song C-H, Lee J-S, Lim K, Kim H-J, Park J-K, Paik T-H Jo E-K (2003) Role of mitogen-activated protein kinase pathways in the production of tumour necrosis factor-α, IL-10, and monocyte chemotactic protein-1 by Mycobacterium tuberculosis H37Rv-infected human monocytes. J Clin Immunol 23: 194 201.
29. Tse HM, Josephy SL, Chan ED, Fouts D Cooper AM (2002) Activation of the mitogen-activated protein kinases signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophages. J Immunol 168: 825 833.
30. Tsuji F, Miyake Y, Aono H, Kawashima Y Mita S (1999) Effects of bucillamine and N-acetyl-l-cysteine on cytokine production and collagen-induced arthritis. Clin Exp Immunol 115: 26 31.
31. Van Crevel R, Ottenhoff TH Van der Meer JW (2002) Innate immunity to Mycobacterium tuberculosis. Clin Microbio Rev 15: 294 309.
32. Venkataraman V, Rodgers T, Linares R, Reilly N, Swaminathan S, Hom D, Millman A, Wallis R Connell N (2006) Tuberculosis immunity in healthy and HIV infected subjects. AIDS Res Ther 3: 5 16.
33. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E Matsumoto K (1995) Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270: 2008 2011.
34. Zhang Y, Broser M Rom WN (1994) Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-κB. Proc Natl Acad Sci USA 15: 2225 2222.