Polystyrene sulfonic acid catalyzed greener synthesis of hydrazones in aqueous medium using microwaves

Tetrahedron Letters

Volumn 48, Issue 32, 2007, Pages 5649-5652

  Polshettiwar, Vivek ^a   Varma, Rajender S ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Aqueous medium; Green chemistry; Hydrazones; Microwave irradiation; Polystyrene sulfonic acid

Indexed keywords

HYDRAZONE DERIVATIVE; POLYSTYRENESULFONIC ACID; WATER;

AQUEOUS SOLUTION; ARTICLE; CATALYSIS; CATALYST; CHEMICAL STRUCTURE; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; MICROWAVE IRRADIATION; MICROWAVE RADIATION; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 34447265189     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.06.038     Document Type: Article

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25. Typical experimental procedure: All the reactions were carried out in CEM discover MW reactor. Typically, the carbonyl compound (1 mmol) and hydrazine (1.2 mmol) were dissolved in 20% PSSA solution in water (three times the weight of ketone/aldehyde). This homogeneous reaction mixture was then exposed to microwaves at 100 °C in a closed system for 8 min and 5 min for ketone and aldehyde, respectively. After completion of the reaction, products were isolated with simple filtration (1-2 mL of water was added to facilitate easy filtration) and washed with methanol to afford pure hydrazones.