Reduction of Post-Surgical Adhesion Formation with Tranilast

Journal of Surgical Research

Volumn 141, Issue 2, 2007, Pages 153-161

  Cooper, Kevin ^a   Young, Janel ^b   Wadsworth, Scott ^b   Cui, Helen ^a   diZerega, Gere S ^c   Rodgers, Kathleen E ^c  

^a ETHICON INC   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

adhesion prevention; tranilast

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; TRANILAST; TRANSFORMING GROWTH FACTOR BETA1;

ADHESION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIODEGRADABILITY; CONTROLLED STUDY; DEVASCULARIZATION; DRUG EFFICACY; FEMALE; LAPAROTOMY; NONHUMAN; PRIORITY JOURNAL; RABBIT; UTERUS HORN; VISCOELASTICITY;

ADHESIONS; ANIMALS; ANTHRANILIC ACIDS; DRUG DELIVERY SYSTEMS; FEMALE; LAPAROTOMY; POSTOPERATIVE COMPLICATIONS; RABBITS;

EID: 34447263521     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2006.05.044     Document Type: Article

References (42)

1. Interceed (TC7) Adhesion Barrier Group. Prevention of post surgical adhesions by intercede (TC7), an absorbable adhesion barrier: A prospective randomized multicenter clinical study. Fertil Steril 51 (1989) 933
2. Diamond M.P., and Seprafilm Adhesion Study Group. Reduction of adhesions after uterine myomectomy by Seprafilm (HAL-F): A blinded, prospective, randomized, multicenter clinical study. Fertil Steril 66 (1996) 904
3. Surgical Membrane Study Group. Prophylaxis of pelvic sidewall adhesion formation with Gore-Tex surgical membrane: A multicenter clinical investigation. Fertil Steril 57 (1992) 921
4. Johns D.B., Keyport G.M., Hoehler F., et al. Intergel adhesions prevention study group: Reduction of PDStsurgical adhesions with Intergel adhesion prevention solution. A multicenter study of safety and efficacy after conservative gynecologic surgery. Fertil Steril 76 (2001) 595
5. Lundorff P., Donnez J., Korell M., et al. Clinical evaluation of a viscoelastic gel for reduction of adhesions following gynaecological surgery by laparoscopy in Europe. Fertil Steril 20 (2005) 514
6. diZerega G.S., Verco S.J.S., Young P., et al. A randomized, controlled pilot study of the safety and efficacy of 4% icodextrin solution in the reduction of adhesions following laparoscopic gynaecological surgery. Hum Reprod 17 (2002) 1031
7. Johns D.A., Ferland R., and Dunn R.I. Initial feasibility study of a sprayable hydrogel adhesion barrier system in patients undergoing laparoscopic ovarian surgery. J Am Assoc Gynecol Laparosc 10 (2003) 339
8. Lundorff P., Donnez J., Korell M., et al. Clinical evaluation of a viscoelastic gel for reduction of adhesions following gynaecological surgery by laparoscopy in Europe. Fertil Steril 20 (2005) 514
9. Young P., Johns A., Templeman C., et al. Reduction of PDStoperative adhesions following laparoscopic gynecological surgery with Oxiplex/AP Gel: A pilot study. Fertil Steril 84 (2005) 1450
10. Mettler L., Audebert A., Lehmann W., et al. Prospective clinical trial of SprayGel as a barrier to adhesion formation: An interim analysis. J Am Assoc Gynecol Laparosc 10 (2003) 339
11. Tulandi T. Introduction-prevention of adhesion formation: The journey continues. Hum Reprod Update 7 (2001) 545
12. Trew G. Consensus in adhesion reduction management. Obstet Gynecol 6 (2004) 1
13. Al-Musawi D., and Thompson J.N. Adhesion prevention: State of the art. Gynecol Endoscopy 10 (2001) 123
14. Canis M., Botchorishvili R., and Tambiurro S.M. Adhesion prevention in the surgical treatment of pelvic endometriosis. Gynecol Endoscopy 10 (2001) 99
15. Rodgers K.E., and diZerega G.S. Developing Pharmacologic agents for adhesions prevention. In: diZerega G.S. (Ed). Peritoneal surgery (2000), Springer-Verlag, New York 441
16. Jackson J.K., Skinner K.C., Burgess L., et al. Paclitaxed-loaded crosslinked hyaluronic acid films fro the prevention of PDStsurgical adhesions. Pharm Res 19 (2002) 411
17. Ozugn H., Cevikel M.H., Kozaci L.D., et al. Lexipafant inhibits PDStsurgical adhesion formation. J Surg Res 103 (2002) 141
18. Duran B., Ak D., Cetin A., et al. Reduction of PDStoperative adhesions by N, O-Carboxymethylchitosan and spermine NONOate in rats. Esp Anim 52 (2003) 267
19. Reed K.L., Brent-Fruin A., Gower A.C., et al. A neurokinin 1 receptor antagonist decreases PDStoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity. PNAS 101 (2004) 9115
20. Holmes Jr. D.R., Savage M., LaBlanche J.M., et al. Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial. Circulation 106 (2002) 1243
21. Garot P., Lefevre T., Savage M., et al. Nine-month outcome of patients treated by percutaneous coronary interventions for bifurcation lesions in the recent era: A report from the Prevention of Restenosis with Tranilast and its Outcomes (Presto) trial. J Am Coll Cardiol 46 (2005) 606
22. Topley N. Cytokine responses to peritoneal inflammation. In: diZerega G.S. (Ed). Peritoneal surgery (2000), Springer-Verlag, New York 75
23. Yasukawa T., Kimura H., Dong J., et al. Effect of tranilast on proliferation, collagen gel contraction, and transforming growth factor beta secretion of retinal pigment epithelial cells and fibroblasts. Ophthalmic Res 34 (2002) 206
24. Miyazawa K., Kikuchi S., Fukuyama J., et al. Inhibition of PDGF- and TGF-beta 1-induced collagen synthesis, migration and proliferation by tranilast in vascular smooth muscle cells from spontaneously hypertensive rats. Atherosclerosis 118 (1995) 213
25. Ward M.R., Agrotis A., Kanellakis P., et al. Tranilast prevents activation of transforming growth factor-β system, leukocyte accumulation, and neointimal growth in porcine coronary arteries after stenting. Arterioscler Thromb Vasc Biol 22 (2002) 940
26. Ward M.R., Sasahara T., Agrotis A., et al. Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries. Atherosclerosis 137 (1998) 267
27. Adachi S., Maruyama T., Kondo T., et al. The prevention of PDStoperative intraperitoneal adhesions by tranilast: N-(3′,4′-dimethoxycinnamoyl) anthranilic acid. Surg Today 29 (1999) 51
28. Koda A., Kurashina Y., and Nakazawa M. The inhibition mechanism of histamine release by N-(3,4-dimethoxycinnamoyl) anthranilic acid. Int Arch Allergy Appl Immunol 77 (1985) 244
29. Liebman S.M., Langer J.C., Marshall J.S., et al. Role of mast cells in peritoneal adhesion formation. Am J Surg 165 (1993) 127
30. Xu X., Rivkind A., Pappo O., et al. Role of mast cells and myofibroblasts in human peritoneal adhesion formation. Ann Surg 236 (2003) 593
31. Fukuyama J., Miyazawa K., Hamano S., et al. Inhibitory effects of tranilast on proliferation, migration, and collagen synthesis of human vascular smooth muscle cells. Can J Physiol Pharmacol 74 (1996) 80
32. waf1 and p53. J Clin Endocrinol Metabol 87 (2002) 5610
33. Inoue H., Ohshima H., Kono H., et al. Suppressive effects of tranilast on the expression of inducible cyclooxygenase (COX2) in interleukin-1β-stimulated fibroblasts. Biochem Pharmacol 53 (1997) 1941
34. 2 from human monocytes-macrophages. Jpn J Pharmacol 60 (1992) 85 a
35. Chikaraishi A., Hirahashi J., Takase O., et al. Tranilast inhibits interleukin-1β-induced monocyte chemoattractant protein-1 expression in rat mesangial cells. Eur J Pharmacol 427 (2001) 151
36. Suzawa H., Kikuchi S., Arai N., et al. The mechanism involved in the ingibitory action of tranilast on collagen biosynthesis of keloid fibroblasts. Jpn J Pharmacol 60 (1992) 91
37. diZerega G.S. Peritoneum, peritoneal healing, and adhesion formation. In: diZerega G.S. (Ed). Peritoneal surgery (2000), Springer-Verlag, New York 3
38. Yamada H., Tajima S., Nishikawa T., et al. Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts. J Biochem 116 (1994) 892
39. Akahori H., Ota T., Torita M., et al. Tranilast prevents the progression of experimental diabetic nephropathy through suppression of enhanced Extracellular matrix gene expression. Pharmacol Exp Ther 27 (2005) 147
40. Martin J., Kelly D.J., Mifsud S.A., et al. Tranilast attenuates cardiac matrix dePDSition in experimental diabetes: Role of transforming growth factor-beta. Cardiovasc Res 65 (2005) 694
41. Mori H., Tanaka H., Kawada K., et al. Suppressive effects of tranilast on pulmonary fibrosis and activation of alveolar macrophages in mice treated with bleomycin: Role of alveolar macrophages in the fibrosis. Jpn J Pharmacol 67 (1995) 279
42. Isaji M., Aruga N., Naito J., et al. Inhibition by tranilast of collagen accumulation in hypersensitive granulomatous inflammation in vivo and of morphological changes and functions of fibroblasts in vitro. Life Sci 55 (1994) PL287