Liver X receptors and epididymal epithelium physiology

Asian Journal of Andrology

Volumn 9, Issue 4, 2007, Pages 574-582

  Saez, Fabrice ^a,b   Chabory, Eléonore ^a   Cadet, Rémi ^a   Vernet, Patrick ^a   Baron, Silvère ^a   Lobaccaro, Jean Marc A ^a   Drevet, Joël R ^a  

^a CRNH AUVERGNE   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

Cholesterol; Epididymis; Gene expression; Lipids; Liver X receptors; Nuclear receptors

Indexed keywords

CELL NUCLEUS RECEPTOR; CHOLESTEROL; FATTY ACID; ISOPROTEIN; LIPID; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; OXYSTEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEGENERATION; CELL FUNCTION; CELL ISOLATION; CHOLESTEROL METABOLISM; CONTROLLED STUDY; EPIDIDYMIS; EPITHELIUM CELL; FATTY ACID METABOLISM; FLAGELLUM; GAS CHROMATOGRAPHY; GENE EXPRESSION REGULATION; GENETIC CODE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPID COMPOSITION; LIVER PARENCHYMA; MACROPHAGE; MALE; MALE INFERTILITY; MALE STERILITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPRODUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPERMATOZOON MATURATION; STAINING; WILD TYPE;

ANIMALS; DNA PRIMERS; DNA-BINDING PROTEINS; EPIDIDYMIS; EPITHELIAL CELLS; FATTY ACIDS; HOMEOSTASIS; LIPIDS; MALE; MICE; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 34447257622     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1111/j.1745-7262.2007.00301.x     Document Type: Article

References (22)

1. Janowski BA, Grogan MJ, Jones SA, Wisely GB, Kliewer SA, Corey EJ, et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A 1999; 96: 266-71.
2. Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev 1995; 9: 1033-45.
3. Volle DH, Lobaccaro JM. Role of the nuclear receptors for oxysterols LXR in steroidogenic tissues: Beyond the "foie gras", the steroids and sex? Mol Cell Endocrinol 2007; 265-66C: 183-9.
4. Volle DH, Mouzat K, Duggavathi R, Siddeek B, Déchelotte P, Sion B, et al. Multiple roles of the nuclear receptors for oxysterols LXR to maintain male fertility. Mol Endocrinol 2007; in press.
5. Frenoux JM, Vernet P, Volle DH, Britan A, Saez F, Kocer A, et al. Nuclear oxysterol receptors, LXR, are involved in the maintenance of mouse caput epididymidis structure and functions. J Mol Endocrinol 2004; 33: 361-75.
6. Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear receptor LXRalpha. Cell 1998; 93: 693-704.
7. Repa JJ, Turley SD, Lobaccaro JA, Medina J, Li L, Lustig K, et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 2000; 289: 1524-9.
8. Force A, Grizard G, Giraud MN, Motta C, Sion B, Boucher D. Membrane fluidity and lipid content of human spermatozoa selected by swim-up method. Int J Androl 2001; 24: 327-34.
9. Mouzat K, Prod'Homme M, Volle DH, Sion B, Déchelotte P, Vanacker JM, et al. Oxysterol nuclear receptor LXRβ regulates cholesterol homeostasis and contractile function in mouse uterus. J Biol Chem 2006; 282: 4693-701.
10. Davies JD, Carpenter KL, Challis IR, Figg NL, McNair R, Proudfoot D, et al. Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells. J Biol Chem 2005; 280: 3911-9.
11. Tabor DE, Kim JB, Spiegelman BM, Edwards PA. Identification of conserved cis -elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2. J Biol Chem 1999; 274: 20603-10.
12. Zhang Y, Zhang X, Chen L, Wu J, Lu WJ, Hwang MT, et al. Liver X receptor (LXR) agonist TO901317 upregulates SCD1 expression in renal proximal straight tubule. Am J Physiol Renal Physiol 2006; 290: F1065-73.
13. Saether T, Tran TN, Rootwelt H, Christophersen BO, Haugen TB. Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis. Biol Reprod 2003; 69: 117-24.
14. Spajic B, Cupic H, Stimac G, Brigic I, Kruslin B, Kraus O. Cholesterol granuloma of the right epididymis mimicking an acute scrotum. Asian J Androl 2006; 8: 749-50.
15. Itoh M, Miyamoto K, Satriotomo I, Takeuchi Y. Spermatic granulomata are experimentally induced in epididymides of mice receiving high-dose testosterone implants. A light-microscopical study. J Androl 1999; 20: 551-8.
16. Jones R. Plasma membrane structure and remodelling during sperm maturation in the epididymis. In:
17. Jones RC, Holland MK, Doberska C, authors. The Epididymis: Cellular and Molecular Aspects. J Reprod Fertil 1998; 53 (Suppl): 73-84.
18. Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, et al. Regulation of sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 2000; 14: 2819-30.
19. Ulven SM, Dalen KT, Gustafsson JA, Nebb HI. LXR is crucial in lipid metabolism. Prostaglandins, Leukot Essent Fatty Acids 2005; 73: 59-63.
20. Heemers HV, Verhoeven G, Swinnen JV. Androgen activation of the sterol regulatory element-binding protein pathway: Current insights. Mol Endo 2006; 20: 2265-77.
21. Miyazaki M, Kim YC, Gray-Keller MP, Attie AD, Ntambi JM. The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. J Biol Chem 2000; 275: 30132-8.
22. Aksoy Y, Aksoy H, Altýnkaynakb K, Rýza Aydýn H, Özkan A. Sperm fatty acid composition in subfertile men. Prostaglandins Leukot Essent Fatty Acids 2006; 75: 75-9.