Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 7, 2007, Pages 2600-2604

  Shi, Minyi ^a,b   Wang, Xin ^b   De Clercq, Erik ^c   Takao, Sonshin ^a   Baba, Masanori ^b,d  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4' AZIDOTHYMIDINE; 4' ETHYNYLSTAVUDINE; 9 (2 PHOSPHONYLMETHOXYPROPYL) 2,6 DIAMINOPURINE; [6 (2 PHOSPHONYLMETHOXY)ETHOXY] 2,4 DIAMINOPYRIMIDINE; ACYCLIC NUCLEOSIDE; ADEFOVIR; NEVIRAPINE; PHOSPHONIC ACID DERIVATIVE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; TENOFOVIR; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; VIRUS INHIBITION; VIRUS REPLICATION;

ADENINE; AMINO ACID SEQUENCE; ANIMALS; ANTIVIRAL AGENTS; CATALYSIS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOGENOUS RETROVIRUSES; HIV-1; HUMANS; KIDNEY; MOLECULAR SEQUENCE DATA; PHOSPHONIC ACIDS; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE INHIBITORS; STAVUDINE; SWINE; SWINE, MINIATURE; VIRUS REPLICATION; ZIDOVUDINE;

EID: 34447253506     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00212-07     Document Type: Article

References (29)

1. Balzarini, J., P. Herdewijn, and E. De Clercq. 1989. Differential patterns of intracellular metabolism of 2′,3′-didehydro-2′, 3′-dideoxythymidine and 3′-azido-2′,3′-dideoxythymidine, two potent anti-human immunodeficiency virus compounds. J. Biol. Chem. 264:6127-6133.
2. Balzarini, J., C. Pannecouque, E. De Clercq, S. Aquaro, C. F. Perno, H. Egberink, and A. Holy. 2002. Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates. Antimicrob. Agents Chemother. 46: 2185-2193.
3. Cooper, D. K., and A. M. Keogh. 2001. The potential role of xenotransplantation in treating endstage cardiac disease: a summary of the report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation. Curr. Opin. Cardiol. 16:105-109.
4. De Clercq, E. 2003. Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections. Clin. Microbiol. Rev. 16:569-596.
5. De Clercq, E. 2007. The acyclic nucleoside phosphonates from inception to clinical use: historical perspective. Antiviral Res. 75:1-13.
6. De Clercq, E., and A. Holy. 2005. Acyclic nucleoside phosphonates: a key class of antiviral drugs. Nat. Rev. Drug Discov. 4:928-940.
7. Goto, M., A. Maeda, L. Elfman, K. M. Suling, J. C. Wood, C. Patience, C. G. Groth, and L. Wennberg. 2004. No transmission of porcine endogenous retrovirus after transplantation of adult porcine islets into diabetic nude mice and immunosuppressed rats. Xenotransplantation 11:340-346.
8. Heneine, W., A. Tibell, W. M. Switzer, P. Sandstrom, G. V. Rosales, A. Mathews, O. Korsgren, L. E. Chapman, T. M. Folks, and C. G. Groth. 1998. No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenografts. Lancet 352:695-699.
9. Hockova, D., A. Holy, M. Masojidkova, G. Andrei, R. Snoeck, E. De Clercq, and J. Balzarini. 2004. Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds. Bioorg. Med. Chem. 12:3197-3202.
10. Hoover, E., J. Ebner, N. S. Zeidner, and J. I. Mullins. 1991. Early therapy of feline leukemia virus infection (FeLV-FAIDS) with 9-(2-phosphonylmethoxyethyl)adenine (PMEA). Antiviral Res. 16:77-92.
11. Izzedine, H., V. Launay-Vacher, A. Baumelou, and G. Deray. 2004. Antiretroviral and immunosuppressive drug-drug interactions: an update. Kidney Int. 66:532-541.
12. Maag, H., R. Rydzewski, M. J. McRoberts, D. Crawford-Ruth, J. P. Verheyden, and E. J. Prisbe. 1992. Synthesis and anti-HIV activity of 4′-azido- and 4′-methoxynucleosides. J. Med. Chem. 37:1440-1451.
13. Macchi, B., I. Faraoni, J. Zhang, S. Grelli, C. Favalli, A. Mastino, and E. Bonmassar. 1997. AZT inhibits the transmission of human T cell leukaemia/lymphoma virus type I to adult peripheral blood mononuclear cells in vitro. J. Gen. Virol. 78:1007-1016.
14. Martin, U., V. Kiessig, J. H. Blusch, A. Haverich, K. von der Helm, T. Herden, and G. Steinhoff. 1998. Expression of pig endogenous retrovirus by primary porcine endothelial cells and infection of human cells. Lancet 352: 692-694.
15. Nitanda, T., X. Wang, H. Kumamoto, K. Haraguchi, H. Tanaka, Y.-C. Cheng, and M. Baba. 2005. Anti-human immunodeficiency virus type 1 activity and resistance profile of 2′,3′-didehydro-3'-deoxy-4′- ethynylthymidine in vitro. Antimicrob. Agents Chemother. 49:3355-3360.
16. Paradis, K., G. Langford, Z. Long, W. Heneine, P. Sandstrom, W. M. Switzer, L. E. Chapman, C. Lockey, D. Onions, E. Otto, et al. 1999. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. Science 285:1236-1241.
17. Patience, C., G. S. Patton, Y. Takeuchi, R. A. Weiss, M. O. McClure, L. Rydberg, and M. E. Breimer. 1998. No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kidneys. Lancet 352:699-701.
18. Patience, C., Y. Takeuchi, and R. A. Weiss. 1997. Infection of human cells by an endogenous retrovirus of pigs. Nat. Med. 3:282-286.
19. Phan-Thanh, L., B. Kaeffer, and E. Bottreau. 1992. Porcine retrovirus: optimal conditions for its biochemical detection. Arch. Virol. 123:255-265.
20. Powell, S. K., M. Artlip, M. Kaloss, S. Brazinski, R. Lyons, G. J. McGarrity, and E. Otto. 1999. Efficacy of antiretroviral agents against murine replication-competent retrovirus infection in human cells. J. Virol. 73:8813-8816.
21. Powell, S. K., M. E. Gates, G. Langford, M.-L. Gu, C. Lockey, Z. Long, and E. Otto. 2000. Antiretroviral agents inhibit infection of human cells by porcine endogenous retroviruses. Antimicrob. Agents Chemother. 44:3432-3433.
22. Qari, S. T., S. Magre, J. G. Garcia-Lerma, A. I. Hussain, Y. Takeuchi, C. Patience, R. A. Weiss, and W. Heneine. 2001. Susceptibility of the porcine endogenous retrovirus to reverse transcriptase and protease inhibitors. J. Virol. 75:1048-1053.
23. Suling, K., G. Quinn, J. Wood, and C. Patience. 2003. Packaging of human endogenous retrovirus sequences is undetectable in porcine endogenous retrovirus particles produced from human cells. Virology 312:330-336.
24. Suruga, Y., M. Makino, Y. Okada, H. Tanaka, E. De Clercq, and M. Baba. 1998. Prevention of murine AIDS development by (R)-9-(2- phosphonylmethoxypropyl)adenine. J. Acquir. Immune. Defic. Syndr. Hum. Retroviral. 18:316-322.
25. Tavares, L., C. Roneker, K. Johnston, S. N. Lehrman, and F. de Noronha. 1987. 3′-Azido-3′-deoxythymidine in feline leukemia virus-infected cats: a model for therapy and prophylaxis of AIDS. Cancer Res. 47:3190-3194.
26. Tisdale, M., S. D. Kemp, N. R. Parry, and B. A. Larder. 1993. Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc. Natl. Acad. Sci. USA 90:5653-5656.
27. Wilson, C. A., S. Wong, J. Muller, C. E. Davidson, T. M. Rose, and P. Burd. 1998. Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells. J. Virol. 72:3082-3087.
28. Yamamoto, O., T. Hamada, N. Tokui, and Y. Sasaguri. 2001. Comparison of three in vitro assay systems used for assessing cytotoxic effect of heavy metals on cultured human keratinocytes. J. UOEH 23:35-44.
29. Ying, C., A. Holy, D. Hockova, Z. Havlas, E. De Clercq, and J. Neyts. 2005. Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities. Antimicrob. Agents Chemother. 49:1177-1180.