Efficacy of antiretroviral agents against murine replication-competent retrovirus infection in human cells

Journal of Virology

Volumn 73, Issue 10, 1999, Pages 8813-8816

  Powell, Sharon K ^a   Artlip, Moria ^a   Kaloss, Michele ^a   Brazinski, Scott ^a   Lyons, Russette ^a   Mcgarrity, Gerard J ^a   Otto, Edward ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; DIDANOSINE; INDINAVIR; LAMIVUDINE; NUCLEOSIDE ANALOG; PROTEINASE INHIBITOR; STAVUDINE; VIRUS VECTOR; ZIDOVUDINE;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MURINE LEUKEMIA VIRUS; PRIORITY JOURNAL; RETROVIRUS INFECTION; VIRUS CELL INTERACTION; VIRUS REPLICATION;

EID: 0032850584     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.10.8813-8816.1999     Document Type: Article

References (32)

1. Balzarini, J., R. Pauwels, M. Baba, P. Herdewijn, E. DeClercq, S. Broder, and D. G. Johns. 1988. The in vitro and in vivo anti-retrovirus activity and intracellular metabolism of 3′-azido-2′,3′-dideojtythymidine and 2′,3′-dideoxycytidine are highly dependent on the cell species. Biochem. Pharmacol. 37:897-903.
2. Balzarini, J., E. Matthes, P. Meeus, D. G. Johns, and E. DeClercq. 1989. The antiretroviral and cytostatic activity, and metabolism of 3′-azido-2′,3′-dideoxythymidine, 3′-fluoro-2′,3′-dideoxythymidine and 2′,3′-dideoxycytidine are highly cell type-dependent. Adv. Exp. Med. Biol. 253B:407-413.
3. Chow, H.-H., P. Li, G. Brookshier, and Y. Tang. 1997. In vivo tissue disposition of 3′-azido-3′-deoxythymidine and its anabolites in control and retrovirus-infected mice. Drug Metab. Dispos. 15:412-422.
4. Coates, J. A. V., N. Cammack, H. J. Jenkinson, A. J. Jowett, M. I. Jowett, B. A. Pearson, C. R. Penn, P. L. Rouse, K. C. Viner, and J. M. Cameron. 1992. (-)-2′Deoxy-3′-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro. Antimicrob. Agents Chemother. 36:733-739.
5. Deeks, S. G., M. Smith, M. Holodniy, and J. O. Kahn. 1997. HIV-1 protease inhibitors: a review for clinicians. JAMA 277:145-153.
6. Deminie, C. A., C. M. Bechtold, D. Stock, M. Alam, F. Djang, A. H. Balch, T.-C. Chou, M. Prichard, R. J. Colonno, and P.-F. Lin. 1996. Evaluation of reverse transcriptase and protease inhibitors in two-drug combinations against human immunodeficiency virus replication. Antimicrob. Agents Chemother. 40:1345-1351.
7. Donahue, R. E., S. W. Kessler, D. Bodine, K. McDonagh, C. Dunbar, S. Goodman, B. Agricola, E. Byrne, M. Raffeld, R. Moen, J. Bacher, K. M. Zsebo, and A. W. Nienhuis. 1992. Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer. J. Exp. Med. 176:1125-1135.
8. Fan, H. 1997. Leukemogenesis by Moloney murine leukemia virus: a multistep process. Trends Microbiol. 5:74-82.
9. Flexner, C., and C. Hendrix. 1997. Pharmacology of anti-retroviral agents, p. 479-493. In V. T. DeVito, Jr., S. Hellman, and S. A. Rosenberg (ed.), AIDS: biology, diagnosis, and prevention. Lippincott-Raven Publishers, Philadelphia, Pa.
10. Fox, B. A., C. Woffendin, Z.-Y. Yang, H. San, U. Ranga, D. Gordon, J. Osterholzer, and G. J. Nabel. 1995. Genetic modification of human peripheral blood lymphocytes with a transdominant negative form of Rev: safety and toxicity. Hum. Gene Ther. 6:997-1004.
11. Gao, Q., Z. Gu, M. A. Parniak, J. Cameron, N. Cammack, C. Boucher, and M. A. Wainberg. 1993. The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2′,3′-dideoxyinosine and 2′,3′-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2′,3′-dideoxy-3′-thiacytidine. Antimicrob. Agents Chemother. 37:1390-1392.
12. Gu, Z., Q. Gao, X. Li, M. A. Parniak, and M. A. Wainberg. 1992. Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2′,3′-dideoxyinosine and 2′,3′-dideoxycytidine. J. Virol. 66:7128-7135.
13. Lacey, S. F., and B. A. Larder. 1994. Novel mutation (V75T) in human immunodeficiency virus type 1 reverse transcriptase confers resistance to 2′,3′-didehydro-2′,3′-dideoxythymidine in cell culture. Antimicrob. Agents Chemother. 38:1428-1432.
14. Lea, A. P., and D. Faulds. 1996. Stavudine: a review of its pharmcodynamic and pharmacokinetic properties and clinical potential in HIV infection. Drugs 5:846-864.
15. Long, Z., L.-P. Li, T. Grooms, C. Lockey, K. Nader, I. Mychkovsky, S. Mueller, I. Burimski, P. Ryan, G. Kikuchi, D. Ennist, S. Marcus, E. Otto, and G. McGarrity. 1998. Biosafety monitoring of patients receiving intracerebral injections of murine retroviral vector producer cells. Hum. Gene Ther. 9:1165-1172.
16. Martineau, D., W. M. Klump, J. E. McCormack, N. J. DePolo, E. Kamantigue, M. Petrowski, J. Hanlon, D. J. Jolly, S. J. Mento, and N. Sajjadi. 1997. Evaluation of PCR and ELISA assays for screening clinical trial subjects for replication-competent retrovirus. Hum. Gene Ther. 8:1231-1241.
17. Mayers, D. L. 1997. Prevalence and incidence of resistance to zidovudine and other anti-retroviral drugs. Am. J. Med. 102:70-75.
18. Menéndez-Arias, L., I. T. Weber, and S. Oroszlan. 1995. Mutational analysis of the substrate binding pocket of murine leukemia virus protease and comparison with human immunodeficiency virus protease. J. Biol. Chem. 270:29162-29168.
19. Menendez-Arias, L., I. T. Weber, J. Soss, R. W. Harrison, D. Gotte, and S. Oroszlan. 1994. Kinetic and modeling studies of subsites S4-S3′ of moloney murine leukemia virus protease. J. Biol. Chem. 269:16795-16801.
20. Menéndez-Arias, L., D. Gotte, and S. Oroszlan. 1993. Moloney murine leukemia virus protease: bacterial expression and characterization of the purified enzyme. Virology 196:557-563.
21. Miller, A. D., and C. Buttimore. 1986. Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol. Cell. Biol. 6:2895-2902.
22. Nicolas, F., G. De Sousa, P. Thomas, M. Placidi, G. Lorenzon, and R. Rahmani. 1995. Comparative metabolism of 3′-azido-3′-deoxythymidine in cultured hepatocytes from rats, dogs, monkeys, and humans. Drug Metab. Dispos. 23:308-313.
23. Otto, E., A. Jones-Trower, E. F. Vanin, K. Stambaugh, S. N. Mueller, W. F. Anderson, and G. J. McGarrity. 1994. Characterization of a replication-competent retrovirus resulting from recombination of packaging and vector sequences. Hum. Gene Ther. 5:567-575.
24. Patel, B. A., F. D. Boudinot, R. F. Schinazi, J. M. Gallo, and C. K. Chu. 1990. Comparative pharmacokinetics and interspecies scaling of 3′-azido-3′-deoxythymidine (AZT) in several mammalian species. J. Pharmacobiodyn. 13:206-211.
25. Quan, Y., Z. Gu, X. Li, Z. Li, C. D. Morrow, and M. A. Wainberg. 1996. Endogenous reverse transcription assays reveal high-level resistance to the triphosphate of (-)2′-dideoxy-3′-thiacytidine by mutated M184V human immunodeficiency virus type 1. J. Virol. 70:5642-5645.
26. Richman, D. D. 1996. HIV therapeutics. Science 272:1886-1888.
27. Sidwell, R. W., M. Hitchcock, K. M. Okleberry, R. A. Burger, R. P. Warren, and J. D. Morrey. 1992. Suppression of murine retroviral disease by 2′,3′-didehydro-2′,3′-dideoxythymidine (d4T). Antivir. Res. 19:313-324.
28. Sin, J.-I., and S. Specter. 1996. The role of interferon-gamma in antiretroviral activity of methionine enkephalin and AZT in a murine cell culture. J. Pharmacol. Exp. Ther. 279:1268-1273.
29. Specter, S., N. Plotnikoff, W. G. Bradley, and D. Goodfellow. 1994. Methionine enkephalin combined with AZT therapy reduce murine retrovirus-induced disease. Int. J. Immunopharmacol. 16:911-917.
30. Tisdale, M., S. D. Kemp, N. R. Parry, and B. A. Larder. 1993. Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc. Natl. Acad. Sci. USA 90:5653-5656.
31. Tókés, S., and J. Aradi. 1995. Inhibition of Moloney murine leukemia virus reverse transcriptase by partially 5-thiolated polyuridylic acid. Biochim. Biophys. Acta 1261:115-120.
32. Tsichlis, P. N., and P. A. Lazo. 1991. Virus-host interactions and the pathogenesis of murine and human oncogenic retroviruses. Curr. Top. Microbiol. Immunol. 171:95-171.