Mitochondrial Superoxide Production Is Related to the Control of Cytokine Release from Peritoneal Macrophage After Antioxidant Treatment in Septic Rats

Journal of Surgical Research

Volumn 141, Issue 2, 2007, Pages 252-256

  de Souza, Luiz Fernando ^a   Ritter, Cristiane ^a,b   Pens Gelain, Daniel ^a   Andrades, Michael ^a   Bernard, Elena Aida ^a   Moreira, Jose Cláudio F ^a   Dal Pizzol, Felipe ^a,b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

Author keywords

cytokines; macrophage; oxidative stress; redox state; sepsis

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CARBONYL DERIVATIVE; CATALASE; CYTOKINE; DEFEROXAMINE; LIPID; PROTEIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; INTRACELLULAR TRANSPORT; MEMBRANE BINDING; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; SEPSIS;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; CYTOKINES; DEFEROXAMINE; MACROPHAGES, PERITONEAL; MALE; MITOCHONDRIA; RATS; RATS, WISTAR; SEPSIS; SIGNAL TRANSDUCTION; SUPEROXIDES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 34447251213     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2006.10.019     Document Type: Article

References (24)

1. Friedman G., Silva E., and Vincent J.L. Has the mortality of septic shock changed with time?. Crit Care Med 26 (1998) 2078
2. Hotchkiss R.S., and Kar I.E. The pathophysiology and treatment of sepsis. New Engl J Med 348 (2003) 138
3. Beutler B., and Poltorak A. Sepsis and evolution of the innate immune response. Crit Care Med 29 (2001) S2
4. Lien E., and Ingalls R.R. Toll-like receptors. Crit Care Med 30 (2002) S1
5. Zhang H., Slutsky A.S., and Vincent J.L. Oxygen free radicals in ARDS, septic shock and organ dysfunction. Int Care Med 26 (2000) 474
6. Victor V.M., and de la Fuente M. Immune cells redox state from mice with endotoxin-induced oxidative stress. Involvement of NF-κB. Free Radic Res 37 (2003) 19
7. Valencia J.V., Weldon S.C., Quinn D., et al. Advanced glycation end products ligands for the receptor for advanced glycation end products: Biochemical characterization and formation kinetics. Anal Biochem 324 (2004) 68
8. Ritter C., Andrades M., Reinke A., et al. Treatment with N-acetylcysteine plus deferoxamine protects rats against oxidative stress and improves mortality in sepsis. Crit Care Med 32 (2004) 342
9. Ritter C., Reinke A., Andrades M., et al. Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats. Crit Care Med 32 (2004) 2079
10. Wichterman K.A., Baue A.E., and Chaudry I.H. Sepsis and septic shock-a review of laboratory models and a proposal. J Surg Res 29 (1980) 189
11. Draper H.H., and Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 186 (1990) 421
12. Levine R.L., Garland D., and Oliver C.N. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 186 (1990) 464
13. Aebi H. Catalase in vitro. Methods Enzymol 105 (1984) 121
14. Bannister J.V., and Calaberese L. Assays for SOD. Methods Biochem Anal 32 (1987) 279
15. Poderoso J.J., Carreras M.C., Lisdero C., et al. Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondrial and submitochondrial particles. Arch Biochem Biophys 328 (1996) 85
16. Victor V.M., Rocha M., and De la Fuente M. Regulation of macrophage function by the antioxidant N-acetylcysteine in mouse-oxidative stress by endotoxin. Int Immunopharmacol 3 (2003) 97
17. Knight J.A. Review: Free radicals, antioxidants, and the immune system. Ann Clin Lab Sci 30 (2000) 145
18. Asehnoune K., Strassheim D., Mitra S., et al. Involvement of reactive oxygen species in toll-like receptor 4-dependent activation of NF-κB. J Immunol 172 (2004) 2522
19. Dal-Pizzol F. Alternative activated macrophage: A new key for systemic inflammatory response syndrome and sepsis treatment?. Crit Care Med 32 (2004) 1971
20. Takahashi H., Tsuda Y., Takeuchi D., et al. Influence of systemic inflammatory response syndrome on host resistance against bacterial infections. Crit Care Med 32 (2004) 1879
21. Andrades M., Ritter C., Moreira J.C.F., et al. Oxidative parameters differences during non-lethal and lethal sepsis development. J Surg Res 125 (2005) 68
22. Ritter C., Cunha A.A., Echer I.C., et al. Effects of N-acetylcysteine plus deferoxamine in LPS-induced acute lung injury in the rat. Crit Care Med 34 (2006) 471
23. Woo C.H., and Lim JH K.J.H. Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells. J Immunol 173 (2004) 6973
24. Zager R.A., Johnson A.C., and Hanson S.Y. Parenteral iron compounds sensitize mice to injury-initiated TNF-alpha mRNA production and TNF-alpha release. Am J Physiol Renal Physiol 288 (2005) F290